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Questions and Answers

Which of the following is the recommended duration of antibiotic therapy for acute uncomplicated pyelonephritis in outpatients?

  • 6 weeks
  • 2 weeks (correct)
  • 4 weeks
  • 1 week

What is the mechanism of action of sulfonamides?

  • They interfere with the formation of nonfunctional derivatives of folic acid
  • They inhibit the production of folic acid in bacteria
  • They kill mature bacteria
  • They compete with PABA for enzyme binding (correct)

What is the half-life of TMP-SMZ (Trimethoprim–sulfamethoxazole)?

  • 6 to 11 hours (correct)
  • 1 to 2 hours
  • 4 to 6 hours
  • 12 to 24 hours

What is the suggested treatment if infection recurs after completing antimicrobial therapy?

<p>Prescribe another short course of full-dose antimicrobial therapy followed by a regular bedtime dose of an antimicrobial agent (A)</p> Signup and view all the answers

Which of the following is a contraindication for the use of ciprofloxacin?

<p>Fragile X syndrome (B)</p> Signup and view all the answers

What is the most common adverse effect of ciprofloxacin?

<p>Rash (A)</p> Signup and view all the answers

Which statement about the pharmacokinetics of ciprofloxacin is correct?

<p>Ciprofloxacin is excreted unchanged in the urine (C)</p> Signup and view all the answers

Which of the following is the most potent fluoroquinolone against gram-negative bacteria?

<p>Ciprofloxacin (C)</p> Signup and view all the answers

Which organism is most likely to cause initial, uncomplicated UTIs in women?

<p>E. coli (B)</p> Signup and view all the answers

Which of the following factors is NOT important when selecting an ideal medication for UTI treatment in women?

<p>High resistance (A)</p> Signup and view all the answers

What is the recommended duration of antibiotic therapy for most cases of uncomplicated UTIs in women?

<p>3 days (B)</p> Signup and view all the answers

What is the primary reason for UTI recurrence within 2 weeks of therapy?

<p>Remnants of the original offending strain (B)</p> Signup and view all the answers

Which of the following is a contraindication for the use of TMP-SMZ?

<p>Known hypersensitivity to any sulfa drug (C)</p> Signup and view all the answers

Which of the following adverse effects can occur with the use of TMP-SMZ?

<p>Increased BUN and serum creatinine (A)</p> Signup and view all the answers

Which of the following is a nursing implication when administering TMP-SMZ parenterally?

<p>Flush IV lines before administration (A)</p> Signup and view all the answers

What is the mechanism of action of TMP-SMZ?

<p>Inhibition of bacterial synthesis of essential nucleic acids and proteins (B)</p> Signup and view all the answers

Which drug is an adjuvant medication used to treat urinary tract infections?

<p>Trimethoprim (C)</p> Signup and view all the answers

What is the main purpose of assessing for signs and symptoms of superinfection or hypersensitivity reactions?

<p>To identify adverse effects of the medication (B)</p> Signup and view all the answers

Which drug should not be taken by older adults due to the risk of renal, pulmonary, and hepatic toxicities?

<p>Nitrofurantoin (B)</p> Signup and view all the answers

What is the recommended fluid intake for patients taking trimethoprim-sulfamethoxazole?

<p>2 to 3 liters per day (A)</p> Signup and view all the answers

Which of the following is a reported renal effect of ciprofloxacin?

<p>Azotemia (D)</p> Signup and view all the answers

Which of the following is a guideline for reducing nephrotoxicity when using ciprofloxacin?

<p>Avoiding substances that alkalinize the urine (A)</p> Signup and view all the answers

Resistance to fluoroquinolone activity is most frequent in which strains of bacteria?

<p>Methicillin-resistant strains (A)</p> Signup and view all the answers

What is a serious concern with the use of fluoroquinolones?

<p>Tendon rupture and tendinitis (B)</p> Signup and view all the answers

Which of the following statements about ciprofloxacin is true?

<p>Ciprofloxacin should only be used in pregnant women with anthrax exposure. (B)</p> Signup and view all the answers

What is the potential risk associated with the use of fluoroquinolones in pregnant women?

<p>Increased risk of torsade de pointes and sudden death. (A)</p> Signup and view all the answers

Which drug should not be used in conjunction with fluoroquinolones?

<p>Antidysrhythmic amiodarone. (A)</p> Signup and view all the answers

What effect does ciprofloxacin have on theophylline clearance?

<p>Ciprofloxacin decreases theophylline clearance. (D)</p> Signup and view all the answers

What can ciprofloxacin chelate with?

<p>Cations. (D)</p> Signup and view all the answers

Which statement about ciprofloxacin interactions is true?

<p>Ciprofloxacin can interact with medications, herbs, and foods. (D)</p> Signup and view all the answers

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