Podcast
Questions and Answers
What are the two main components of dosage forms?
What are the two main components of dosage forms?
- Active pharmaceutical ingredient and drug additives (correct)
- Inactive ingredients and active ingredient
- Drug delivery systems and drug formulations
- Active pharmaceutical ingredient and multiple drugs
The term 'drug product' refers to an unfinished dosage form.
The term 'drug product' refers to an unfinished dosage form.
False (B)
What is the primary purpose of pharmaceutical preparations?
What is the primary purpose of pharmaceutical preparations?
To make a drug entity ready for use.
Amoxicillin belongs to the _____ group.
Amoxicillin belongs to the _____ group.
Match the following terms with their definitions:
Match the following terms with their definitions:
Who is known as the father of the USP?
Who is known as the father of the USP?
The National Formulary was established after the USP.
The National Formulary was established after the USP.
What is the primary purpose of the USP?
What is the primary purpose of the USP?
The Pure Food and Drug Act was signed by _____ in 1906.
The Pure Food and Drug Act was signed by _____ in 1906.
What was the first name of the National Formulary?
What was the first name of the National Formulary?
Match the following terms with their definitions:
Match the following terms with their definitions:
The latest editions of USP and NF are the USP 42nd and NF 37th.
The latest editions of USP and NF are the USP 42nd and NF 37th.
The _____ assesses the physicochemical properties of a substance like pH and dissolution.
The _____ assesses the physicochemical properties of a substance like pH and dissolution.
What is one of the main functions of dosage forms?
What is one of the main functions of dosage forms?
Additives or excipients in dosage forms can include anti-oxidants.
Additives or excipients in dosage forms can include anti-oxidants.
What is the purpose of providing a controlled-release dosage form?
What is the purpose of providing a controlled-release dosage form?
The method designed to transport a pharmaceutical compound into the body is known as the _____ system.
The method designed to transport a pharmaceutical compound into the body is known as the _____ system.
Match the following terms to their definitions:
Match the following terms to their definitions:
Which of the following routes of administration is included in the extravascular category?
Which of the following routes of administration is included in the extravascular category?
Pharmaceutical compounds cannot be administered intravascularly.
Pharmaceutical compounds cannot be administered intravascularly.
What is one reason for film coating a drug?
What is one reason for film coating a drug?
Which study focuses on determining the effects of a compound on gene mutation?
Which study focuses on determining the effects of a compound on gene mutation?
Reproductive Studies are conducted to evaluate the effects of compounds on mammalian reproduction.
Reproductive Studies are conducted to evaluate the effects of compounds on mammalian reproduction.
What is the main goal of pre-formulation studies in the drug development process?
What is the main goal of pre-formulation studies in the drug development process?
Studies aimed at collecting basic information on the _____ and _____ characteristics of the drug substance are part of the pre-formulation process.
Studies aimed at collecting basic information on the _____ and _____ characteristics of the drug substance are part of the pre-formulation process.
Match the following drug characteristics with their definitions:
Match the following drug characteristics with their definitions:
Which characteristic is NOT associated with a Goal Drug?
Which characteristic is NOT associated with a Goal Drug?
High-throughput screening can examine up to 15,000 chemical compounds per week.
High-throughput screening can examine up to 15,000 chemical compounds per week.
What is the primary aim of random or untargeted screening in drug discovery?
What is the primary aim of random or untargeted screening in drug discovery?
Bioassays are used to differentiate the effect and __________ of the test agent.
Bioassays are used to differentiate the effect and __________ of the test agent.
Match the methods of drug discovery to their descriptions:
Match the methods of drug discovery to their descriptions:
What is a key downside of random screening methods?
What is a key downside of random screening methods?
Molecular modification involves the chemical alteration of previously defined lead compounds.
Molecular modification involves the chemical alteration of previously defined lead compounds.
What kind of testing does high-throughput screening utilize?
What kind of testing does high-throughput screening utilize?
Study Notes
USP Overview
- Established in 1820 to standardize medicine in the U.S., enhancing public health and safety.
- Initially listed almost 563 drugs over 272 pages.
- Aimed to achieve consistent quality and therapeutic merit in pharmaceuticals.
National Formulary
- Created as a compendium for pharmaceutical standards, first known as the National Formulary of Unofficial Preparations in 1888.
- Renamed National Formulary in 1906 after the Pure Food and Drug Act was enacted.
- Purchase of NF by USP in 1975 unified the two compendia, latest editions being USP 42nd and NF 37th.
Monographs
- A monograph defines the standards for the identity, strength, purity, and consistency of a drug substance.
- Includes identification tests, assay methods, purity assessments, physicochemical quality measures, and storage requirements.
- Crucial for ensuring correct packaging and labeling of pharmaceutical products.
Dosage Forms
- Defined as formulated preparations for administering drugs, consisting of active pharmaceutical ingredients (APIs) and additives.
- Protects drug entities from environmental damage and provides an optimal means for drug delivery.
- Types include solid dosage forms, which can be controlled-release or delayed-release for consistent absorption rates.
Drug Delivery Systems
- Methods to transport pharmaceutical compounds into the body efficiently.
- Route of administration can be intravascular (e.g., intravenous) or extravascular.
Goal Drug Characteristics
- A theoretical drug ideally meeting treatment criteria: desired effects, preferred administration route, minimal dosage, optimal action duration, and no side effects.
Drug Discovery Methods
- Random or Untargeted Screening: Tests numerous compounds for biological activity without specific targets, though some compounds may be missed.
- Bioassays: Differentiate effects and potency of test agents using cell cultures.
- High-Throughput Screening: Evaluates up to 15,000 compounds weekly with multiple assays.
- Molecular Modification: Involves chemical alterations of known compounds to improve efficacy or safety.
Pre-Clinical Studies
- Pre-formulation studies gather essential information on drug characteristics, aiming to develop an optimal delivery system.
- Focus on physical and chemical properties including solubility, stability, and dissolution rates.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Explore the origins and significance of the United States Pharmacopeia (USP), established in 1820. This quiz covers its foundational principles, key reasons for standardization, and the importance of quality in medicine. Test your knowledge on the precursors of the USP and its impact on pharmaceutical standards.
