History of Teratogens in Pregnancy

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Questions and Answers

What is the main concern with thalidomide use in the first trimester of pregnancy?

  • Excessive weight gain in the mother
  • Increased risk of premature labor
  • Development of gestational diabetes
  • Limb-reduction defects in the fetuses (correct)

What is encompassed by the term 'teratogens'?

  • Postpartum depression and anxiety
  • Structural abnormalities and abnormal growth (correct)
  • Maternal hypertension and diabetes
  • Gestational diabetes and excessive weight gain

When can drug effects on target organs be most significant during pregnancy?

  • During the third trimester
  • During lactation
  • During the second trimester
  • During the first trimester (correct)

What do medications in Pregnancy Risk Category C indicate?

<p>The benefits may outweigh the risks in certain situations (B)</p> Signup and view all the answers

What did the initial determination of thalidomide's safety lead to?

<p>Delayed recognition of its harmful effects (C)</p> Signup and view all the answers

What is the meaning of Pregnancy Category X for medication use?

<p>Risk of the use of the drug in pregnant women outweighs any possible benefit and is contraindicated in pregnancy (D)</p> Signup and view all the answers

What percentage of pregnant women receive prescription drugs known to carry a fetal risk according to the AJOG study?

<p>5% (B)</p> Signup and view all the answers

What factors affect the transfer of drugs into breastmilk?

<p>Maternal plasma protein binding and size of the drug molecule (B)</p> Signup and view all the answers

What is the estimated percentage of drugs marketed in the US over the past 20 years for which teratogenic risk is still undetermined?

<p>About 90% (A)</p> Signup and view all the answers

What is the main concern for health care professionals regarding drug use during pregnancy?

<p>Balancing maximum benefit with minimizing risk (A)</p> Signup and view all the answers

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