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History of Teratogens in Pregnancy

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Questions and Answers

What is the main concern with thalidomide use in the first trimester of pregnancy?

Excessive weight gain in the mother

Increased risk of premature labor

Development of gestational diabetes

Limb-reduction defects in the fetuses (correct)

What is encompassed by the term 'teratogens'?

Postpartum depression and anxiety

Structural abnormalities and abnormal growth (correct)

Maternal hypertension and diabetes

Gestational diabetes and excessive weight gain

When can drug effects on target organs be most significant during pregnancy?

During the third trimester

During lactation

During the second trimester

During the first trimester (correct)

What do medications in Pregnancy Risk Category C indicate?

The benefits may outweigh the risks in certain situations Signup and view all the answers

What did the initial determination of thalidomide's safety lead to?

Delayed recognition of its harmful effects Signup and view all the answers

What is the meaning of Pregnancy Category X for medication use?

Risk of the use of the drug in pregnant women outweighs any possible benefit and is contraindicated in pregnancy Signup and view all the answers

What percentage of pregnant women receive prescription drugs known to carry a fetal risk according to the AJOG study?

5% Signup and view all the answers

What factors affect the transfer of drugs into breastmilk?

Maternal plasma protein binding and size of the drug molecule Signup and view all the answers

What is the estimated percentage of drugs marketed in the US over the past 20 years for which teratogenic risk is still undetermined?

About 90% Signup and view all the answers

What is the main concern for health care professionals regarding drug use during pregnancy?

Balancing maximum benefit with minimizing risk Signup and view all the answers