10 Questions
What is the main concern with thalidomide use in the first trimester of pregnancy?
Limb-reduction defects in the fetuses
What is encompassed by the term 'teratogens'?
Structural abnormalities and abnormal growth
When can drug effects on target organs be most significant during pregnancy?
During the first trimester
What do medications in Pregnancy Risk Category C indicate?
The benefits may outweigh the risks in certain situations
What did the initial determination of thalidomide's safety lead to?
Delayed recognition of its harmful effects
What is the meaning of Pregnancy Category X for medication use?
Risk of the use of the drug in pregnant women outweighs any possible benefit and is contraindicated in pregnancy
What percentage of pregnant women receive prescription drugs known to carry a fetal risk according to the AJOG study?
5%
What factors affect the transfer of drugs into breastmilk?
Maternal plasma protein binding and size of the drug molecule
What is the estimated percentage of drugs marketed in the US over the past 20 years for which teratogenic risk is still undetermined?
About 90%
What is the main concern for health care professionals regarding drug use during pregnancy?
Balancing maximum benefit with minimizing risk
Explore the historical impact of teratogens on fetal development, such as the notorious case of thalidomide causing limb-reduction defects in fetuses. Learn about the effects of drugs administered during pregnancy and lactation, and the recognition of teratogenic effects over time.
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