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Questions and Answers

An oophorectomized monkey is treated with high doses of estrogen. Which of the following changes is most likely to occur in the endometrium after 1 year of treatment?

  • Atrophy
  • Hypertrophy
  • Hypoplasia
  • Hyperplasia (correct)
  • Metaplasia

Which of the following muscle cell components helps spread the depolarization of the muscle cell membranes throughout the interior of muscle cells?

  • Actin
  • Myosin
  • Troponin
  • Tropomyosin
  • Z disk
  • T tubule (correct)

A new drug is developed that prevents the demyelinization occurring in the progress of multiple sclerosis. The drug protects the cells responsible for the synthesis and maintenance of myelin in the central nervous system. These cells are most likely which of the following?

  • Oligodendrocyte (correct)
  • Microglial cell
  • Astrocyte
  • Schwann cell
  • Ependymal cell

A 10-year-old boy undergoes an appendectomy. Granulation tissue develops normally at the incision site. Tissue remodeling begins at this site with degradation of collagen in the extracellular matrix by which of the following proteins?

<p>Metalloproteinase (C)</p> Signup and view all the answers

In which of the following nuclear structures is DNA actively transcribed to rRNA?

<p>Nucleolus (E)</p> Signup and view all the answers

A 22-year-old man is brought to the emergency department in respiratory distress 15 minutes after he was stung on the arm by a wasp. His pulse is 100/min, respirations are 30/min, and blood pressure is 100/60 mm Hg. Physical examination shows grunting respirations and subcostal retractions. Expiratory wheezes are heard over both lung fields. There is generalized urticaria. Secretion of the molecule causing this patient's symptoms is most likely mediated by which of the following?

<p>Activation of mast cell (E)</p> Signup and view all the answers

A 66-year-old man with Zollinger-Ellison syndrome undergoes a gastrectomy. He is informed that he will require treatment with intramuscular vitamin B12 (cyanocobalamin) for the rest of his life. This therapy is necessary because this patient lacks which of the following types of cells?

<p>Parietal (D)</p> Signup and view all the answers

Beginning with protein synthesis in membrane-bound ribosomes, hepatocytes secrete proteins into the circulation via which of the following mechanisms?

<p>Transport in vesicles and exocytosis (E)</p> Signup and view all the answers

Which of the following is required to transport fatty acids across the inner mitochondrial membrane?

<p>Carnitine (C)</p> Signup and view all the answers

An experiment is conducted in which the mitochondrial content of various tissues is studied. It is found that the mitochondrial content is directly proportional to the amount of energy one cell is required to generate and expend. The mitochondrial content is most likely greatest in which of the following types of cells?

<p>Cardiac muscle cells (C)</p> Signup and view all the answers

A 45-year-old man without a history of bleeding or excessive bruising dies suddenly due to rupture of an aortic dissection. Genetic analysis at autopsy shows a defect in the gene for fibrillin. Which of the following events most likely occurs with defective fibrillin?

<p>Elastic fibers in the extracellular matrix are not correctly formed (C)</p> Signup and view all the answers

A 42-year-old woman comes to the physician for a follow-up examination after two separate Pap smears have shown dysplastic epithelial cells. Results of a molecular diagnostic test show DNA that encodes high-risk versions of the human papillomavirus E6 and E7 proteins. The viral E6 protein binds to the cellular p53 tumor suppressor gene, causing it to be degraded. Which of the following best describes the mechanism by which the E6 protein causes cervical cancer?

<p>Prevents apoptosis (A)</p> Signup and view all the answers

Which of the following is the correct sequence of events in the initiation of contraction of a skeletal muscle fiber?

<p>Depolarization of Sarcolemma (2), Conformational Change in Troponin-Tropomyosin Complex (5), Release of Ca2+ from Sarcoplasmic Reticulum (4), Propagation into Transverse Tubules (3), Acetylcholine Binding to Receptors (1) (A)</p> Signup and view all the answers

A 90-year-old woman is brought to the emergency department 30 minutes after she fell while climbing the steps into her house. Physical examination shows tenderness over the right shin area. An x-ray of the right lower extremity shows a fracture of the tibia. A DEXA scan shows decreased bone density. Increased activity of which of the following cell types is the most likely cause of the decrease in bone mass in this patient?

<p>Osteoclasts (D)</p> Signup and view all the answers

A 50-year-old man comes to the physician because of a cough productive of large quantities of mucus for 6 months. He has smoked 1 pack of cigarettes daily for 25 years. Which of the following cell types is the most likely cause of the increase in this patient's secretion of mucus?

<p>Goblet cells (E)</p> Signup and view all the answers

A 65-year-old man with severe atherosclerotic coronary artery disease comes to the emergency department because of a 12-hour history of chest pain. Plasma activity of the MB isozyme of creatine kinase (MB-CK) is markedly increased. Which of the following processes is the most likely explanation for the increased plasma MB-CK?

<p>Cell membrane damage (D)</p> Signup and view all the answers

During an experimental study, an investigator finds that the regulation of cell cycle and programmed cell death may be initiated by the mitochondrion. The interaction of the mitochondrion with the activation of the caspase family of proteases and subsequent apoptosis is most likely mediated by which of the following?

<p>Cytochrome c release (D)</p> Signup and view all the answers

A 48-year-old man has hepatic cancer that is unresponsive to standard therapy. He enrolls in a clinical study of a novel chemotherapeutic agent that, as a side effect, blocks kinesin, a component of the cellular microtubular transport system. One week later, he develops skeletal muscle weakness. An alteration in which of the following components of the neuromuscular junction is the most likely cause of the muscle weakness?

<p>A decrease in the number of presynaptic neurotransmitter vesicles (B)</p> Signup and view all the answers

A polysome is actively involved in translation. The ribosomes are attached to which of the following?

<p>mRNA (C)</p> Signup and view all the answers

A pathologist uses monoclonal antibodies against several intermediate filament proteins and finds that a tumor section stains positive for cytokeratin only. The tumor most likely originated from which of the following tissues?

<p>Epithelial (D)</p> Signup and view all the answers

Flashcards

Histology

The study of the structure of tissues and cells.

Apoptosis

A process of programmed cell death, crucial for tissue development and homeostasis.

Immune System

The system responsible for protecting the body from foreign invaders.

Respiratory System

The system responsible for gas exchange, including oxygen intake and carbon dioxide removal.

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Gastrointestinal System

System responsible for the breakdown and absorption of nutrients.

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Mitochondrial Content

The amount of energy one cell is required to generate and expend.

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Tissue Remodeling

Degradation of collagen in the extracellular matrix.

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P53 Tumor Suppressor Gene

The viral E6 protein binds to this cellular tumor suppressor gene.

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Muscle Fiber Contraction

The correct sequence of events in the initiation of contraction of a skeletal muscle fiber.

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Cell Cycle Regulation

The regulation of cell cycle and programmed cell death.

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Study Notes

Histology Systems Overview

  • General Principles of Foundational Science make up 30-35%
  • Immune System comprise 1-5%
  • Blood & Lymphoreticular System consist of 1-5%
  • Nervous System & Special Senses account for 5-10%
  • Skin & Subcutaneous Tissue covers 1-5%
  • Musculoskeletal System entail 1-5%
  • Cardiovascular System makes up 1-5%
  • Respiratory System consist of 1-5%
  • Gastrointestinal System covers 5-10%
  • Renal & Urinary System accounts for 5-10%
  • Pregnancy, Childbirth, & the Puerperium make up 1-5%
  • Female Reproductive System & Breast consist of 1-5%
  • Male Reproductive System covers 1-5%
  • Endocrine System accounts for 5-10%

Sample Questions and Answers

  • Question 1: An oophorectomized monkey treated with high doses of estrogen for a year will likely experience hyperplasia in the endometrium
  • Question 2: T tubules help spread depolarization of the muscle cell membranes throughout the muscle cells
  • Question 3: Oligodendrocytes are the cells most likely protected by a drug that prevents demyelinization
  • Question 4: Matrix degradation of collagen is carried out by metalloproteinase
  • Question 5: DNA is actively transcribed to rRNA in the nucleolus
  • Question 6: Activation of mast cells likely mediates the symptoms after a wasp sting
  • Question 7: Parietal cells are lacked by a gastrectomy patient with Zollinger-Ellison syndrome
  • Question 8: Hepatocytes secrete proteins into the circulation via transport in vesicles and exocytosis
  • Question 9: Carnitine is required to transport fatty acids across the inner mitochondrial membrane
  • Question 10: Cardiac muscle cells have the greatest mitochondrial content
  • Question 11: Elastic fibers in the extracellular matrix are not correctly formed due to defective fibrillin
  • Question 12: Viral E6 protein causes cervical cancer by preventing apoptosis, thus sustaining angiogenesis
  • Question 13: The correct sequence in skeletal muscle fiber contraction is 2-5-4-3-1
  • Question 14: Increased activity of osteoclasts is the most like cause the decreased bone mass
  • Question 15: Goblet cells are the most likely cause of the increase in secretion of mucus
  • Question 16: Cell membrane damage explains the increased plasma MB-CK
  • Question 17: Cytochrome c release mediate the interaction of the mitochondrion with the caspase family
  • Question 18: A decrease in the number of presynaptic neurotransmitter vesicles is the most likely cause of skeletal muscle weakness
  • Question 19: Ribosomes attach to mRNA
  • Question 20: A tumor staining positive for cytokeratin only most likely originated from Epithelial tissues

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