Histology Stains and Markers Quiz

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Match the stain with its primary usage:

Prussian blue stain = Iron in hemosiderin turns blue to black when exposed to potassium ferrocyanide Thioflavin T = Used for amyloidosis Mucicarmine stain = Used for adenocarcinoma Periodic Acid Schiff (PAS) = Useful in identifying fungi, parasites, glycogen, and the basement membrane

Match the marker with its staining pattern:

CD34 = Positive in DFSP Factor XIIIa = Negative in DFSP S100 protein = Non-specific stain commonly used in the diagnosis of melanoma Neuron specific enolase = Stains merkel cells

Match the staining technique with its target substance:

Fontana Masson stain = Melanin black for dematiaceous fungi identification Gormorimethenamine silver = Stains fungi, parasites, Donovan bodies, and Rhinoscleroma black Von Kossa stain = Identifies calcium by staining it black Cytokeratin 7 = Associated with extramammary Paget's disease

Match the stain with its target organism or substance:

Cryptococcus capsule stain = Stains Cryptococcus capsule red Rhinosporidium = Stained by Periodic Acid Schiff (PAS) HMB45 = Stains melanocytic lesions such as melanoma CD68 = Positive in Rosai Dorfman syndrome Signup and view all the answers

Match the following immunohistochemical stains with their respective tumor types:

S100 +ve, CD68 +ve = Atypical fibroxanthoma Vimentin +ve, Smooth muscle actin +ve = Glomus tumor Vimentin +ve, Smooth muscle actin +ve, Desmin +ve = Leiomyosarcoma S100 +ve, MBP +ve, Vimentin +ve = Schwannoma or Neurolemmoma Signup and view all the answers

Match the following gene mutations with their associated conditions:

MEFV gene = FMF: Pyrin SPG31 = Spastic paraplegia CARD15 (NOD2) gene = Early onset sarcoidosis CKIT = Mastocytosis Signup and view all the answers

Match the following neoplasms with their characteristic immunohistochemical stains:

Merkel cell carcinoma = S100 +ve, HMB45 +ve, Vimentin +ve Desmoplastic melanoma = Vimentin +ve, Smooth muscle actin +ve, Desmin +ve Trichoblastoma = Vimentin +ve, S100 +ve Basal cell carcinoma = CK20, Paget disease Signup and view all the answers

Match the following syndromes with their associated gene mutations or tests:

Carcinoid syndrome = Metastasis to the liver POEMS syndrome = Lambda light chain Signup and view all the answers

Match the following skin lesions with their most likely locations on the body:

Venous lake = Lower lip basal cell carcinoma = Scalp Trichoblastoma = Scalp syringocystadenoma papilliferum = Scalp Signup and view all the answers

What is the most likely diagnosis based on the clinical and histologic findings of a 63-year-old female with a papillomatous yellow-orange plaque on the scalp and a smooth, pink nodule paracentrally within the plaque?

Trichoblastoma arising in association with nevus sebaceus Signup and view all the answers

In suspected carcinoid syndrome, which urine test should be ordered?

5-HIAA Signup and view all the answers

What is the most common cancer in POEMS syndrome?

Osteosclerotic myeloma Signup and view all the answers

Where on the body would a venous lake most likely present?

Lower lip or the ear Signup and view all the answers

What are the immunohistochemical markers for DFSP?

CD+ve, vimentin +ve Signup and view all the answers

What are the immunohistochemical markers for atypical fibroxanthoma?

S100+ve, CD68+ve Signup and view all the answers

What are the immunohistochemical markers for shwanomma or Neurolemmoma?

S100+ve, MBP +ve, vimentin +ve Signup and view all the answers

What are the immunohistochemical markers for melanoma?

S100 +ve, HMB45+ve, vimentin +ve Signup and view all the answers

What are the immunohistochemical markers for glomus tumor?

Vimentin +ve, Smooth muscle actin +ve Signup and view all the answers

What are the immunohistochemical markers for leimyosarcoma?

Vimentin +ve, Smooth muscle actin +ve, Desmin +ve Signup and view all the answers

What is the gene associated with mastocytosis?

CKIT Signup and view all the answers

What is the gene associated with early onset sarcoid?

CARD15 (NOD2) gene Signup and view all the answers

What stain is used to identify iron in hemosiderin?

Perls' Prussian blue stain Signup and view all the answers

Which stain is useful in identifying fungi, parasites, glycogen, and the basement membrane?

Periodic Acid Schiff (PAS) Signup and view all the answers

What stain is used to identify melanin and helps identify dematiaceous fungi?

Fontana Masson stain Signup and view all the answers

Which stain is used to identify calcium by staining it black?

Von Kossa stain Signup and view all the answers

What stain is commonly used as an adjunctive marker in the diagnosis of melanoma?

S100 protein Signup and view all the answers

Which stain is used to identify amyloidosis?

Thioflavin T Signup and view all the answers

What stain is used to identify extramammary Paget's disease?

Cytokeratin 7 Signup and view all the answers

Which stain is used to identify adenocarcinoma?

Mucicarmine stain Signup and view all the answers

What stain is used to identify mastocytosis?

Toulidine blue Signup and view all the answers

Which stain stains fungi, parasites, Donovan bodies, and Rhinoscleroma black?

Gormorimethenamine silver Signup and view all the answers

What stain is used to identify merkel cells?

Neuron specific enolase Signup and view all the answers

Which stain is positive in Rosai Dorfman syndrome?

CD68 Signup and view all the answers

Which stain is used to identify iron in hemosiderin?

Perls' Prussian blue stain Signup and view all the answers

What stain is commonly used as an adjunctive marker in the diagnosis of melanoma?

S100 protein Signup and view all the answers

What stain is used to identify amyloidosis?

Thioflavin T Signup and view all the answers

What stain is used to identify mastocytosis?

Toulidine blue Signup and view all the answers

What stain is used to identify melanin and helps identify dematiaceous fungi?

Fontana Masson stain Signup and view all the answers

What stain is used to identify calcium by staining it black?

Von Kossa stain Signup and view all the answers

What is the most likely diagnosis based on the clinical and histologic findings of a 63-year-old female with a papillomatous yellow-orange plaque on the scalp and a smooth, pink nodule paracentrally within the plaque?

Trichoblastoma arising in association with nevus sebaceus Signup and view all the answers

In suspected carcinoid syndrome, which urine test should be ordered?

5-HIAA Signup and view all the answers

What is the most common cancer in POEMS syndrome?

Osteosclerotic myeloma Signup and view all the answers

Where on the body would a venous lake most likely present?

Lower lip or the ear Signup and view all the answers

What gene mutation is associated with mastocytosis?

CKIT Signup and view all the answers

What stain is used to identify extramammary Paget's disease?

CK20 Signup and view all the answers

Which urine test should be ordered in suspected carcinoid syndrome?

5-HIAA Signup and view all the answers

What is the gene associated with early onset sarcoid?

CARD15 (NOD2) gene Signup and view all the answers

What are the immunohistochemical markers for shwanomma or Neurolemmoma?

S100+ve, MBP +ve, vimentin +ve Signup and view all the answers

What are the immunohistochemical markers for melanoma?

S100 +ve, HMB45+ve, vimentin +ve Signup and view all the answers

What stain is useful in identifying fungi, parasites, glycogen, and the basement membrane?

PAS stain Signup and view all the answers

What stain is used to identify mastocytosis?

CKIT Signup and view all the answers

Histology Stains and Markers Quiz

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Questions and Answers

Match the stain with its primary usage:

Match the marker with its staining pattern:

Match the staining technique with its target substance:

Match the stain with its target organism or substance:

Match the following immunohistochemical stains with their respective tumor types:

Match the following gene mutations with their associated conditions:

Match the following neoplasms with their characteristic immunohistochemical stains:

Match the following syndromes with their associated gene mutations or tests:

Match the following skin lesions with their most likely locations on the body:

What is the most likely diagnosis based on the clinical and histologic findings of a 63-year-old female with a papillomatous yellow-orange plaque on the scalp and a smooth, pink nodule paracentrally within the plaque?

In suspected carcinoid syndrome, which urine test should be ordered?

What is the most common cancer in POEMS syndrome?

Where on the body would a venous lake most likely present?

What are the immunohistochemical markers for DFSP?

What are the immunohistochemical markers for atypical fibroxanthoma?

What are the immunohistochemical markers for shwanomma or Neurolemmoma?

What are the immunohistochemical markers for melanoma?

What are the immunohistochemical markers for glomus tumor?

What are the immunohistochemical markers for leimyosarcoma?

What is the gene associated with mastocytosis?

What is the gene associated with early onset sarcoid?

What stain is used to identify iron in hemosiderin?

Which stain is useful in identifying fungi, parasites, glycogen, and the basement membrane?

What stain is used to identify melanin and helps identify dematiaceous fungi?

Which stain is used to identify calcium by staining it black?

What stain is commonly used as an adjunctive marker in the diagnosis of melanoma?

Which stain is used to identify amyloidosis?

What stain is used to identify extramammary Paget's disease?

Which stain is used to identify adenocarcinoma?

What stain is used to identify mastocytosis?

Which stain stains fungi, parasites, Donovan bodies, and Rhinoscleroma black?

What stain is used to identify merkel cells?

Which stain is positive in Rosai Dorfman syndrome?

Which stain is used to identify iron in hemosiderin?

What stain is commonly used as an adjunctive marker in the diagnosis of melanoma?

What stain is used to identify amyloidosis?

What stain is used to identify mastocytosis?

What stain is used to identify melanin and helps identify dematiaceous fungi?

What stain is used to identify calcium by staining it black?

What is the most likely diagnosis based on the clinical and histologic findings of a 63-year-old female with a papillomatous yellow-orange plaque on the scalp and a smooth, pink nodule paracentrally within the plaque?

In suspected carcinoid syndrome, which urine test should be ordered?

What is the most common cancer in POEMS syndrome?

Where on the body would a venous lake most likely present?

What gene mutation is associated with mastocytosis?

What stain is used to identify extramammary Paget's disease?

Which urine test should be ordered in suspected carcinoid syndrome?

What is the gene associated with early onset sarcoid?

What are the immunohistochemical markers for shwanomma or Neurolemmoma?

What are the immunohistochemical markers for melanoma?

What stain is useful in identifying fungi, parasites, glycogen, and the basement membrane?

What stain is used to identify mastocytosis?

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