Histology: Muscular Tissue

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Questions and Answers

Which characteristic primarily defines muscle tissue?

  • Contractile cells for movement (correct)
  • Supporting the nervous system
  • Epithelial lining of organs
  • Secretion of hormones

Muscle cells originate from which germ layer?

  • Endoderm
  • Mesoderm (correct)
  • Blastoderm
  • Ectoderm

What is the key feature differentiating striated from smooth muscle?

  • Nucleus location
  • Cell shape
  • Vascularity
  • Presence of cross-striations (correct)

Which type of striated muscle is restricted to soft tissues and involved in processes like speech and swallowing?

<p>Visceral striated muscle (D)</p>
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The cytoplasm of a muscle cell is also known as what?

<p>Sarcoplasm (B)</p>
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What is the main function of the smooth endoplasmic reticulum in muscle cells?

<p>Calcium storage (A)</p>
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Which of the following is a primary function of muscle tissue?

<p>Movement of the body (C)</p>
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Besides movement, what other essential function do muscles perform in relation to the body's stability?

<p>Maintenance of posture (D)</p>
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Which muscular function directly supports oxygen and carbon dioxide exchange in the body?

<p>Respiration (C)</p>
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Muscle contration and relaxation contribute most directly to which of the following?

<p>Production of body heat (D)</p>
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Facial expressions are possible by muscles fulfilling the function of:

<p>Communication (C)</p>
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What is the role of muscles in the constriction of organs and vessels?

<p>Regulating organ volume and blood flow (B)</p>
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Cardiac muscle contributes directly to which essential function?

<p>Blood circulation (C)</p>
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Which property of muscle tissue allows it to shorten and generate force?

<p>Contractility (C)</p>
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What characteristic enables muscle tissue to respond to stimuli, such as nerve signals?

<p>Excitability (C)</p>
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The ability of muscle tissue to be stretched without damage is known as:

<p>Extensibility (B)</p>
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What property allows muscle tissue to return to its original length after being stretched?

<p>Elasticity (D)</p>
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Skeletal muscle is correctly defined as:

<p>Long, multinucleated cells (C)</p>
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Skeletal muscle fibers develop through the fusion of what type of cells?

<p>Myoblasts (D)</p>
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What type of cell aids in the repair of damaged skeletal muscle tissue?

<p>Satellite cells (C)</p>
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The connective tissue layer that surrounds an entire skeletal muscle is called the?

<p>Epimysium (A)</p>
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Bundles of muscle fibers within a skeletal muscle are known as:

<p>Fascicles (C)</p>
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What type of connective tissue surrounds each individual muscle fiber?

<p>Endomysium (C)</p>
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Within a skeletal muscle fiber, what structure is composed of repeating units called sarcomeres?

<p>Myofibril (B)</p>
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Which of the following best describes a sarcomere?

<p>The area between two Z-lines of a myofibril (A)</p>
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What are the two main types of myofilaments found in a sarcomere?

<p>Actin and myosin (C)</p>
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Myosin filaments are primarily found spanning which region of the sarcomere?

<p>A-band (D)</p>
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What protein is the primary component of thin myofilaments?

<p>Actin (A)</p>
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Which protein covers the active sites on actin in a relaxed muscle?

<p>Tropomyosin (C)</p>
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Which of the following does calcium bind to during muscle contraction, triggering a conformational change?

<p>Troponin (D)</p>
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What is the role of ATP in muscle contraction?

<p>Detachment of myosin from actin (D)</p>
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What events directly initiate the release of calcium ions into the sarcoplasm, leading to muscle contraction?

<p>ACh binding to receptors (C)</p>
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In skeletal muscle, what is the role of the sarcolemma, T tubules, and sarcoplasmic reticulum in the process of muscle contraction?

<p>Electrical signal transmission (C)</p>
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Which of the following structures are responsible for the mechanical aspects of muscle contraction?

<p>Myofibrils and myofilaments (D)</p>
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During muscle contraction, what happens to the distance between the Z discs in a sarcomere?

<p>Decreases (A)</p>
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Which type of skeletal muscle fiber is best suited for endurance activities due to its high myoglobin content and oxidative phosphorylation?

<p>Slow oxidative fibers (Type I) (C)</p>
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Which type of skeletal muscle fiber primarily uses anaerobic glycolysis and fatigues more quickly?

<p>Fast glycolytic fibers (Type IIb) (B)</p>
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Compared to slow oxidative fibers, fast glycolytic fibers have:

<p>Higher myosin-ATPase activity (D)</p>
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Which type of skeletal muscle fiber is typically found in postural muscles of the back?

<p>Slow oxidative fibers (Type I) (A)</p>
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Which classification considers both the presence of cross-striations and the location of muscle tissue?

<p>Classification based on appearance and location. (A)</p>
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What is the functional impact of the arrangement of myofibrils within a muscle cell?

<p>Enables coordinated and directional force generation during contraction. (C)</p>
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How does the presence of myosin ATPase in the heads of thick myofilaments directly contribute to skeletal muscle contraction?

<p>It catalyzes the hydrolysis of ATP, providing energy for the power stroke. (C)</p>
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What role do satellite cells play in skeletal muscle tissue, and under what conditions are they activated?

<p>Repairing damaged muscle tissue. (D)</p>
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What is the physiological consequence of a sustained release of calcium ions into the sarcoplasm during muscle contraction?

<p>Sustained muscle contraction due to continuous active site exposure on actin. (C)</p>
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How do the regulatory proteins, tropomyosin and troponin, work together to control muscle contraction in skeletal muscle?

<p>Tropomyosin blocks the myosin-binding sites on actin, and calcium binding to troponin causes it to move, exposing the sites. (B)</p>
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How does the distribution of the connective tissue coverings (epimysium, perimysium, and endomysium) contribute to the overall function of skeletal muscle?

<p>They provide structural support, pathways for blood vessels and nerves, and transmit force generated by muscle fibers. (A)</p>
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In a muscle contraction, what is the direct role of ATP after the power stroke has occurred?

<p>To facilitate the release of myosin from actin. (C)</p>
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How does the length of the filaments within the sarcomere affect force generation?

<p>Force generation depends on the degree of overlap between thick and thin filaments within the sarcomere. (B)</p>
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How do transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) interact to regulate muscle contraction?

<p>T-tubules transmit the action potential, which then causes the SR to release calcium ions. (A)</p>
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Flashcards

Muscle Tissue

Tissue composed of contractile cells responsible for movement.

Muscle Classification: By Appearance

Muscles are classified into striated and smooth based on appearance under a light microscope.

Muscle Classification: By Location

Striated muscle is sub-classified into skeletal, visceral, and cardiac based on location.

Muscle Fibers

Muscle cells are also known as fibers.

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Sarcoplasm

The cytoplasm of muscle cells.

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Sarcoplasmic Reticulum

The smooth endoplasmic reticulum in muscle cells.

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Sarcolemma

The cell membrane of a muscle cell.

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Sarcosomes

Mitochondria in muscle cells.

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Muscle Functions

Muscles facilitate body movement, posture maintenance, respiration, and more.

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Contractility

The ability of muscle tissue to shorten and generate force.

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Excitability

The ability of muscle tissue to respond to stimuli.

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Extensibility

The ability of muscle tissue to be stretched.

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Elasticity

The ability of muscle tissue to return to its original length after stretching.

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Skeletal Muscle

Muscle composed of long, multinucleated cells.

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Epimysium

Thick dense irregular connective tissue surrounding each skeletal muscle.

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Perimysium

Thin connective tissue that surrounds bundles of fibers.

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Endomysium

Very thin reticular fibers surrounding individual muscle fiber.

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Sarcomere

Region of a myofibril that spans two Z lines.

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Myofilaments

Parallel arrangements on sarcomere.

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Thick myofilaments

Myofilaments that span region of A-band.

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Thin myofilaments

Contains actin, and is a myofilament.

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Electrical Components

Sarcolemma, transverse tubules and sarcoplasmic reticulum.

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Mechanical components

Myofibiril and Myofilament

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Skeletal Muscle Contraction

Electrical signal causes filaments slide past each other.

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Study Notes

  • UST (University of Santo Tomas) General Santos presents Unit 3 of Histology: Muscular Tissue.
  • The unit aims to identify types of muscular tissues and their functions.

Overview and Classification

  • Muscle tissue features contractile cells for movement.
  • Muscle cells originate from the mesoderm.

Muscle Classification by Appearance

  • Striated muscle has cross-striations under a light microscope.
  • Smooth muscle lacks cross-striations.

Muscle Classification by Location

  • Skeletal muscle facilitates axial and appendicular skeleton movement.
  • Visceral striated muscle, restricted to soft tissues, aids speech, breathing, and swallowing.
  • Cardiac muscle resides in the heart wall and large veins at the heart's base.

Muscle Tissue Terminology

  • Muscle cells are known as fibers.
  • Cytoplasm is specifically referred to as sarcoplasm.
  • Smooth endoplasmic reticulum is called sarcoplasmic reticulum.
  • The cell membrane is termed sarcolemma.
  • Mitochondria are known as sarcosomes.

Functions of Muscles

  • Movement of the body
  • Maintaining posture
  • Respiration
  • Creating body heat
  • Communication
  • Constriction of organs and vessels
  • Heart contraction

Muscle Tissue Properties

  • Contractility
  • Excitability
  • Extensibility
  • Elasticity

Skeletal Muscle

  • Skeletal muscle consists of multinucleated muscle cells.

Skeletal Muscle Organization

  • Epimysium, a thick, dense, irregular connective tissue, surrounds each skeletal muscle and contains nerves, blood vessels, and lymphatics.
  • Perimysium is a thin connective tissue around each bundle of muscle fibers, called fascicles, and contains nerves, blood vessels, and lymphatics.
  • Endomysium features thin reticular fibers around individual muscle fibers and contains nerve fibers, capillaries, and scattered fibroblasts.

Skeletal Muscle Cell Components

Myofibril

  • Each muscle fiber contains 5,000-10,000 myofibrils.
  • Myofibrils span the entire muscle fiber length.
  • They are 1-2 micrometers in diameter.
  • They are arranged parallel to the cell's long axis.
  • Myofibrils are composed of repeating sarcomere units.
  • They exhibit transverse striations of alternating light and dark bands.

Sarcomere

  • A myofibril region spans two z-lines.
  • Sarcomeres represent the smallest contractile subunit of muscle fiber.
  • A resting sarcomere measures 1.5-2 micrometers long.
  • They consist of filaments.

Myofilaments

  • The sarcomere has 1,000-2,000 myofilaments, arranged parallel to its long axis.
  • There are two types: thick and thin.
  • Thick myofilaments are located in the midzone of the sarcomere, spanning the A-band region, are 15 nm in diameter, 1.5 um long, and contain myosin.
  • Thin myofilaments run between thick filaments, span the A-band region, measure 8 nm in diameter, 1 um long, and contain actin, tropomyosin, and troponin.

Thin Myofilaments Function

  • Globular (G) actin contains receptor sites for myosin head.
  • Tropomyosin in relaxed muscle covers the active sites on G actin subunits.
  • Troponin attaches to tropomyosin, binds to calcium, and regulates actin and myosin interaction.

Skeletal Muscle Contraction

  • Muscle contraction has electrical and mechanical components.
  • The electrical components are the sarcolemma, transverse tubules, and sarcoplasmic reticulum, which respond to and transmit signals.
  • The mechanical components are the myofibril and myofilament, which perform contraction.

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