Histamine and Immune Response Quiz

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Questions and Answers

What is the primary therapeutic use of antihistamines?

To activate the immune response

To increase the production of antigens

To interfere with the action of histamine (correct)

To enhance the action of histamine

Which of the following statements about histamine is true?

Histamine acts as an effective medication for allergies.

Histamine itself has no clinical applications. (correct)

Histamine has significant side effects when used therapeutically.

Histamine is used in many clinical applications.

Which of the following is NOT associated with physical trauma?

Chemical exposure

Severe tissue damage

Emotional stress response (correct)

Antigen-antibody reaction

What is a common component involved in immune responses?

Antibodies Signup and view all the answers

Which process involves the interaction between a foreign substance and antibodies?

Antigen-antibody reaction Signup and view all the answers

What is the result of mast cell destruction in the context of tissue damage?

Release of histamine Signup and view all the answers

What is the primary effect of histamine release on blood vessels at the site of injection?

Vasodilatation of blood vessels Signup and view all the answers

Which of the following describes the direct action of histamine after mast cell destruction?

Vasodilatation at the injection site Signup and view all the answers

Which cellular component is primarily involved in the release of histamine?

Mast cells Signup and view all the answers

What initiates the process of vasodilatation following tissue injury?

Destruction of mast cells Signup and view all the answers

What is a consequence of the trauma of prick on blood vessels?

It increases blood vessel permeability. Signup and view all the answers

Which substance is released due to a prick trauma that affects blood vessels?

Endogenous histamine Signup and view all the answers

What is the role of the triple response of Lewis in the context of a prick trauma?

It describes the response of histamine released. Signup and view all the answers

How does the extent of the response to prick trauma compare to a histamine injection?

It is less than that of a histamine injection. Signup and view all the answers

What condition does increased blood vessel permeability typically lead to following a prick?

Localized edema. Signup and view all the answers

What is the source of internal histamine release in the body?

Mast cells Signup and view all the answers

What effect does adrenaline have on capillary permeability?

It reduces permeability. Signup and view all the answers

How does external histamine differ from internal histamine?

External histamine comes from injections. Signup and view all the answers

What role does histamine play in the body's response?

Increases blood flow to tissues. Signup and view all the answers

What type of receptor does adrenaline primarily act on?

α-agonist receptors Signup and view all the answers

What is described as a physiological antagonist to endogenous histamine?

Antihistamines Signup and view all the answers

Which observation is associated with the action of the physiological antagonist mentioned?

Pallor area Signup and view all the answers

What is NOT a characteristic effect when using the physiological antagonist to histamine?

Wheal formation Signup and view all the answers

In the context of allergic reactions, which effect is generally absent when the physiological antagonist is applied?

Inflammatory response Signup and view all the answers

Which of the following statements is true regarding the physiological antagonist to histamine?

It does not cause wheal formation. Signup and view all the answers

Study Notes

Physical Trauma

Physical trauma can trigger the release of histamine, a substance involved in inflammatory responses.
Trauma can come in various forms, like pricking or injections.
The extent of histamine release is dependent on the severity of the trauma.

Antigen-Antibody Reaction

Antigen-antibody reactions can also trigger histamine release.

Various Chemicals

Histamine itself has limited direct clinical applications but can be influenced by other chemicals.
Antihistamines are medications designed to counteract the effects of histamine, playing important roles in treatment.

Mast Cell Destruction

Mast cells are important cellular components in the immune system.
Destruction of mast cells can lead to the release of histamine, contributing to inflammation.

Histamine Effects

Histamine causes vasodilation, which is the widening of blood vessels.
It also increases vascular permeability, allowing for more fluid to leak out into the surrounding tissue.

Histamine Release

Pricking releases endogenous histamine, which is produced by the body.
Injecting histamine causes a more significant release compared to pricking.

Adrenaline

Adrenaline (epinephrine) is a hormone that acts as a vasoconstrictor, meaning it narrows blood vessels.
It counteracts the effects of endogenous histamine, resulting in reduced redness and swelling.
While adrenaline can reduce histamine effects on the skin, it might cause paleness around the injection site.

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Description

Explore the crucial role of histamine in physical trauma and its interaction with antigen-antibody reactions. This quiz covers the physiological effects of histamine, including vasodilation and increased vascular permeability, as well as the significance of mast cells in the immune response.