16 Questions
What is the primary mechanism by which histamine is released from mast cells?
Phospholipase C mechanism
What is the primary effect of histamine on blood vessels?
Vasodilation
Which of the following is a treatment option for preventing histamine release?
Mast cell stabilisers
What is the primary effect of histamine on nerves?
Itchiness
What is the primary mechanism by which α-adrenoceptor agonists work to counteract the effects of histamine?
Physiologically opposing histamine action
What is the primary reason for the rapid metabolism of histamine?
To ensure local action and prevent systemic effects
What is the primary mechanism of histamine release from mast cells?
Degranulation of mast cells through IgE-mediated signaling
What is the result of histamine's cellular effects on the nasal passages in allergic rhinitis?
Increased mucus production and vasodilation
What are the two primary enzymes involved in histamine metabolism?
Diamine oxidase and Histamine-N-methyltransferase
What is the name of the autocoid that is rapidly metabolized to ensure local action?
Histamine
What is the primary purpose of histamine release in allergic reactions?
To initiate a rapid immune response
What is the role of α adrenoreceptor agonists in counteracting histamine-induced effects?
They cause vasoconstriction to counteract histamine-induced vasodilation
What is the primary mechanism by which histamine is released during an allergic response?
IgE antibodies bind to mast cells, triggering histamine release
What is the primary effect of histamine on blood vessels?
Vasodilation and increase in vascular permeability
What is the purpose of leukotriene receptor antagonists in treating allergic rhinitis?
To antagonize the action of leukotrienes on airway smooth muscle
What is the primary role of histamine in the allergic response?
To mediate the allergic response through H1 receptors
This quiz covers the role of histamine in allergic rhinitis, including its effects on cellular responses and the body's regulation of histamine levels. It is relevant to minor illness and respiratory conditions.
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