Hepatocellular Carcinoma Morphology and Growth
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Questions and Answers

What type of morphology is associated with HCC that resembles normal hepatocytes with trabecular or pseudoglandular architecture?

  • Diffuse
  • Multifocal
  • Unifocal
  • Well-differentiated (correct)
  • Which factor is responsible for causing a lack of differentiation and uncontrolled proliferation in HCC?

  • Vascular invasion
  • Intrahepatic metastasis
  • Cytokine (correct)
  • Extrahepatic metastasis
  • What does an elevated level of Alpha-fetoprotein (AFP) in blood tests indicate?

  • Normal liver function
  • Hepatocellular carcinoma (HCC) (correct)
  • Presence of portal triads in tumor
  • Metastasis to the lungs
  • Which type of HCC morphology consists of multiple tiny nodules spread without a dominant nodule and is poorly differentiated?

    <p>Diffuse</p> Signup and view all the answers

    What is the effect of invasion of the portal vein by HCC cells?

    <p>Occlusion of portal circulation</p> Signup and view all the answers

    Which stage of HCC is associated with extrahepatic metastasis to other organs?

    <p>Advanced stage</p> Signup and view all the answers

    What characterizes poorly differentiated HCC morphology?

    <p>Anaplastic cells with little/no resemblance to normal cells</p> Signup and view all the answers

    Which imaging scan is specifically mentioned as NOT suitable for large tumors in the provided text?

    <p>Magnetic resonance imaging (MRI)</p> Signup and view all the answers

    What is the purpose of embolization in treating liver cancer according to the text?

    <p>To stop blood flow towards the tumor to kill it</p> Signup and view all the answers

    Which therapy involves drugs or substances specifically binding to receptors on tumor cells according to the text?

    <p>Targeted therapy</p> Signup and view all the answers

    What lifestyle change is NOT specifically recommended in the text for managing liver cancer?

    <p>Increase alcohol consumption</p> Signup and view all the answers

    Which condition leads to poor oral health in patients with chronic liver disease according to the text?

    <p>Cirrhosis of the liver</p> Signup and view all the answers

    What is the purpose of ablation therapy in treating liver cancer according to the text?

    <p>To burn tumors using a needle</p> Signup and view all the answers

    Which treatment option involves removing part of the liver?

    <p>Surgery: Hepatectomy</p> Signup and view all the answers

    Which form of liver cancer is the most common type?

    <p>Hepatocellular Carcinoma</p> Signup and view all the answers

    What is one of the major etiologic factors for Hepatocellular Carcinoma?

    <p>Chronic alcoholism/cirrhosis</p> Signup and view all the answers

    How does HBV contribute to Hepatocellular Carcinoma development?

    <p>By directly integrating HBV DNA into the host genome</p> Signup and view all the answers

    Which factor leads to synthesis of triglycerides in hepatocellular carcinoma associated with chronic alcoholism?

    <p>ROS production</p> Signup and view all the answers

    What is a characteristic feature of Aflatoxin as a hepatocarcinogen?

    <p>Forms mutagenic adducts with DNA</p> Signup and view all the answers

    In which condition does HCV mostly work exclusively for hepatocarcinogenesis?

    <p>Advanced cirrhosis</p> Signup and view all the answers

    What is the most appropriate treatment for Hepatocellular Carcinoma in its early stages?

    <p>Surgery to remove tumor or liver transplant</p> Signup and view all the answers

    What is one common manifestation of advanced liver disease that makes Hepatocellular Carcinoma more common?

    <p>End-stage liver cirrhosis</p> Signup and view all the answers

    What is the minimum number of metabolic syndrome features that must be present to diagnose Non-Alcoholic Fatty Liver Disease (NAFLD)?

    <p>3 out of 5</p> Signup and view all the answers

    In the histologic features of cirrhosis, what causes the creation of fibrotic tissues via collagen?

    <p>Activation of Hepatic Stellate Cells (HSC)</p> Signup and view all the answers

    Which abnormal nodules in cirrhosis become hyperplastic and can lead to moderate genomic instability?

    <p>Nodules caused by proliferation and degeneration</p> Signup and view all the answers

    What classification does the most poorly differentiated HCC cells fall under?

    <p>Poorly Differentiated</p> Signup and view all the answers

    Which two common early mutational events are associated with Hepatocellular Carcinoma (HCC) pathogenesis?

    <p>Activation of β-catenin and inactivation of p16</p> Signup and view all the answers

    What is the consequence of continuous cell division in the liver that damages DNA repair mechanisms?

    <p>Accumulation of mutations</p> Signup and view all the answers

    Which factor is associated with aflatoxin inactivating p53 in the pathogenesis of HCC?

    <p>IL-6 overexpression</p> Signup and view all the answers

    'Chronic hepatitis' refers to repeated cycles of cell death and regeneration, leading to what significant outcome?

    <p>Accumulation of mutations due to damaged DNA repair mechanisms</p> Signup and view all the answers

    Which oral manifestation is NOT associated with liver dysfunction?

    <p>Oral lichen planus</p> Signup and view all the answers

    What is a characteristic sign of advanced liver disease that may be observed in the oral cavity?

    <p>Fetor hepaticus</p> Signup and view all the answers

    How does portal hypertension affect nutrient absorption in patients with liver disease?

    <p>Impairs nutrient absorption</p> Signup and view all the answers

    What is a common risk factor for dental caries in patients with liver disease?

    <p>Dry mouth</p> Signup and view all the answers

    In patients with liver cirrhosis, what causes an increased risk of gingival bleeding?

    <p>Decrease in coagulation factors produced</p> Signup and view all the answers

    What is the primary reason tooth extraction may be required in patients with liver cirrhosis?

    <p>Severe dental caries</p> Signup and view all the answers

    What is one important aspect to consider in the dental management of patients with liver disease?

    <p>Cross-infection management for HBV and HCV</p> Signup and view all the answers

    'Dry gland syndrome' associated with primary biliary cirrhosis primarily involves which glands?

    <p>Tear glands and salivary glands</p> Signup and view all the answers

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