Hepatitis E Virus & Hypertension Portalis

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Questions and Answers

Quae causa communissima hypertensio portalis est?

Insufficientia cordis congestiva
Pericarditis constrictiva
Syndroma Budd-Chiari
Cirrhosis (correct)

Quae conditio non pertinet ad hypertensionem portalem?

Hepatitis fulminans
Syndroma Budd-Chiari
Diabetes mellitus (correct)
Cirrhosis

Quae ex sequentibus est causa secundum hypertensio portalis et non primaria?

Cirrhosis
Hepatitis fulminans
Insufficientia cordis (correct)
Syndroma Budd-Chiari

Quae ex sequentibus non est causa hypertensionis portalis?

Vasculitis (A) Signup and view all the answers

Quae ex conditionibus infra est nota causa hypertensio portalis?

Syndroma Budd-Chiari (B), Cirrhosis (C), Hepatitis fulminans (D) Signup and view all the answers

Quis ex sequentibus treatmentis complicati praecipuus est ad varices?

TIPS (B) Signup and view all the answers

Quid inter sequentia non pertinet ad complices tractandos?

Hypotensio (B) Signup and view all the answers

Quod ex sequentibus medicamentorum methodis pertinet ad hepatic encephalopathy?

Cura lactulose (B) Signup and view all the answers

Quod instrumentum diagnostico adhibetur ad evaluandum ascites?

Echocardiography (C) Signup and view all the answers

Quae ex sequentibus methodis est ad tractandum hypersplenism?

Surgical shunt (B) Signup and view all the answers

Quod conditionem indicat serum creatinine non melius fieri post diureticos suspensionem?

Creatinine stabilis maior quam 1.5 mg/dl post duas dies (B) Signup and view all the answers

Quod sensum statum aegrorum in sua medicandi processione non ostendit?

Shock absentis (C) Signup and view all the answers

Quod regimen medicinale ad serum creatinine↓ < 1.5 mg/dl necessarium est post duas dies?

Albumin adminiculum 1 g/kg/die (A) Signup and view all the answers

Quot diebus diureticorum suspensionem requiritur ante serum creatinine specificandum?

Duobus diebus (D) Signup and view all the answers

Quod est maximum aliquot albumin 100 g/die in 1 g/kg/die administratione?

100 g (B) Signup and view all the answers

Quae est incubationis perioada virus hepatitidis E?

2-6 weeks (A) Signup and view all the answers

Quid est modo transmissionis virus hepatitidis E?

Fecal-oral (A) Signup and view all the answers

Qualis est structura virus hepatitidis E?

RNA virus (C) Signup and view all the answers

Quam remedium relapsantium hepatitidis simile est?

Tractationi simili cum morbo sibi limitato (D) Signup and view all the answers

Quid est principalis causa pathogenesis virus hepatitidis E?

Destructio hepatocitarum per immunitatem (B) Signup and view all the answers

Quid fit cum alcoholis 20% metabolizatur per cytochrome CYP2E1?

Generantur radicales oxygenii liberi (A) Signup and view all the answers

Quid consequitur ex lipid peroxidatione in hepatocitis?

Damnum mitochondrial (B) Signup and view all the answers

Quae est secunda consecutio principalis metabolismi alcoholis in hepaticis?

Necrosis cellulis (C) Signup and view all the answers

Quod processus in hepaticis occurrit post lipid peroxidationem?

Inflammatio et fibrosi (C) Signup and view all the answers

Quid significat mitochondrial damage in contextu alcoholis?

Decrescens energiae (C) Signup and view all the answers

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Study Notes

Hypertension Portalis

Causa frequentissima est cirrhosis (80%).
Alii causae sunt: Insufficientia cordis congestiva, Pericarditis constrictiva, Syndroma Budd-Chiari (BCS) et morbus veno-occlusivus, Hepatitis fulminans.

Hepatitis E Virus (HEV)

Epidemiologia:
- Distributio lata.
- Transmissio:
  - Fecal-oralis (per aquam).
  - Materno-neonatalis.
- Periodo incubationis: 2 septimanae - 6 septimanae.
Virus:
- Virus RNA, Hepeviridae, 27 nm.
Pathogenesis:
- Destructio hepatocytorum immunitate mediata.
20% alcoholis:
- Metabolisatur per cytochrome CYP2E1 in acetatum, liberando radicales oxygenii liberi → peroxidatio lipidiorum → damnum mitochondriorum → damnum hepaticum.