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Questions and Answers
What is the significance of testing for anti-HBc Ab when HBs Ag becomes negative?
What is the significance of testing for anti-HBc Ab when HBs Ag becomes negative?
It determines whether past hepatitis B infection has occurred, guiding blood donation safety.
What does a positive anti-HBs Ab and negative anti-HBc Ab indicate regarding blood donation?
What does a positive anti-HBs Ab and negative anti-HBc Ab indicate regarding blood donation?
It indicates that the donor should be deferred from donation.
What are the AABB recommendations concerning the anti-HBc antibody?
What are the AABB recommendations concerning the anti-HBc antibody?
Any donor with a positive anti-HBc antibody should be deferred.
How is safe blood determined according to the WHO guidelines in the context of anti-HBs and anti-HBc antibodies?
How is safe blood determined according to the WHO guidelines in the context of anti-HBs and anti-HBc antibodies?
In what scenario is blood from a donor with positive anti-HBs Ab considered safe?
In what scenario is blood from a donor with positive anti-HBs Ab considered safe?
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Study Notes
WHO Recommendations on Hepatitis B Testing
- Essential to test for anti-HBc Ab when HBs Ag becomes negative in patients with a history of HBV.
- Evaluation of the anti-HBs Ab and anti-HBc Ab combinations is crucial for determining blood safety.
Anti-HBs and Anti-HBc Antibody Interpretation
- Positive Anti-HBs Ab and Positive Anti-HBc Ab: Safe for blood donation if > 100 IU/L.
- Positive Anti-HBs Ab and Negative Anti-HBc Ab: Blood donation deferred.
- Negative Anti-HBs Ab and Positive Anti-HBc Ab: Blood donation deferred.
- Negative Anti-HBs Ab and Negative Anti-HBc Ab: Safe for blood donation.
AABB Recommendations
- All donors with positive anti-HBc antibody should be deferred from donating blood to ensure safety.
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