Infections of the Liver

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Questions and Answers

What is one of the main roles of the liver in the digestive system?

  • Absorbing fats directly from the diet
  • Producing hormones and enzymes for digestion (correct)
  • Filtering nutrients from the small intestine
  • Producing bile for the immune system

What does jaundice indicate about liver function?

  • The liver is functioning properly
  • The liver is not clearing old RBCs effectively (correct)
  • The liver is producing excess bilirubin
  • The liver is enlarging due to inflammation

What is the primary cause of jaundice in premature newborns?

  • Delayed liver function development (correct)
  • Infection with hepatitis virus
  • Excessive exposure to sunlight
  • Ingestion of maternal toxins

What is crucial for the proper processing of bilirubin by the liver?

<p>Adequate liver function (B)</p> Signup and view all the answers

Which of the following is NOT a common cause of jaundice?

<p>Increased dietary fiber intake (B)</p> Signup and view all the answers

What is the structure of the Hepatitis A Virus?

<p>Nonenveloped, single-stranded RNA (B)</p> Signup and view all the answers

What can phototherapy do for newborns with jaundice?

<p>Process bilirubin into molecules for elimination (D)</p> Signup and view all the answers

Which statement about hepatitis is false?

<p>It is caused only by viral infections. (A)</p> Signup and view all the answers

Hepatitis viruses are grouped together because they:

<p>Infect the liver despite their differences (D)</p> Signup and view all the answers

What occurs when old RBCs are not processed by the liver effectively?

<p>Bilirubin accumulates in the bloodstream. (A)</p> Signup and view all the answers

What is the primary route of transmission for Hepatitis A Virus (HAV)?

<p>Fecal-oral route (A)</p> Signup and view all the answers

Which hepatitis virus is associated with a higher risk of chronic infection and liver cirrhosis?

<p>Hepatitis C Virus (HCV) (B), Hepatitis B Virus (HBV) (C)</p> Signup and view all the answers

What symptom is commonly seen in patients with Hepatitis B Virus (HBV) that is not typically associated with Hepatitis A Virus (HAV)?

<p>Arthritis (D)</p> Signup and view all the answers

Which of the following is true about the Hepatitis D Virus (HDV)?

<p>It causes more severe infections when co-infected with HBV. (D)</p> Signup and view all the answers

What is the primary reason for the lack of a vaccine for Hepatitis C Virus (HCV)?

<p>HCV mutates too rapidly. (A)</p> Signup and view all the answers

Which symptom is more frequently associated with Hepatitis B than with Hepatitis A?

<p>Loss of appetite (D)</p> Signup and view all the answers

What is a significant risk factor for transmitting Hepatitis B Virus (HBV)?

<p>Sharing personal items with infected individuals (C)</p> Signup and view all the answers

Which hepatitis virus is considered 'non-A non-B' before its identification?

<p>Hepatitis C Virus (HCV) (D)</p> Signup and view all the answers

What is the major route of dissemination for Hepatitis C Virus (HCV)?

<p>Blood contact (C)</p> Signup and view all the answers

In the context of hepatitis transmission, what does HAV outbreak typically correlate with?

<p>Poor hygiene in food preparation (B)</p> Signup and view all the answers

The liver produces hormones and enzymes that are essential for digestion.

<p>True (A)</p> Signup and view all the answers

Jaundice can occur even if the liver is functioning properly.

<p>False (B)</p> Signup and view all the answers

Hepatitis is an inflammatory disease of the liver caused by various viruses.

<p>True (A)</p> Signup and view all the answers

Infection with hepatitis viruses leads to the same symptoms in all cases.

<p>False (B)</p> Signup and view all the answers

Bilirubin is a pigment that can accumulate in the body and cause yellowing of the skin when not processed by the liver.

<p>True (A)</p> Signup and view all the answers

Phototherapy is ineffective in treating jaundice in newborns.

<p>False (B)</p> Signup and view all the answers

Hepatitis A Virus (HAV) is an enveloped virus.

<p>False (B)</p> Signup and view all the answers

Chronic drug and alcohol use can lead to liver malfunction and jaundice.

<p>True (A)</p> Signup and view all the answers

A lack of normal microflora in the liver makes it susceptible to infections.

<p>False (B)</p> Signup and view all the answers

The primary cause of jaundice in adults is typically liver infection.

<p>False (B)</p> Signup and view all the answers

Hepatitis A Virus (HAV) can cause severe complications such as liver cirrhosis.

<p>False (B)</p> Signup and view all the answers

Hepatitis B Virus (HBV) is often identified through the detection of its Surface Antigen.

<p>True (A)</p> Signup and view all the answers

Hepatitis C Virus (HCV) is an RNA virus that often presents symptoms immediately after infection.

<p>False (B)</p> Signup and view all the answers

The Hepatitis D Virus (HDV) can infect individuals independently of Hepatitis B Virus (HBV).

<p>False (B)</p> Signup and view all the answers

Transmission of Hepatitis A Virus (HAV) results primarily from contact with contaminated water supplies.

<p>False (B)</p> Signup and view all the answers

Chronic infection with Hepatitis C Virus (HCV) can eventually lead to the need for liver transplantation.

<p>True (A)</p> Signup and view all the answers

There is a vaccine available for both Hepatitis C Virus (HCV) and Hepatitis E Virus (HEV).

<p>False (B)</p> Signup and view all the answers

Hepatitis B Virus (HBV) can be transmitted through sexual contact and sharing contaminated utensils.

<p>True (A)</p> Signup and view all the answers

Mild symptoms such as

<p>True (A)</p> Signup and view all the answers

Hepatitis E Virus (HEV) is primarily transmitted through sexual contact.

<p>False (B)</p> Signup and view all the answers

Which type of Hepatitis virus has a 15-160 days incubation period?

<p>Hepatitis B (HBV) (C)</p> Signup and view all the answers

What is the classification of Hepatitis A Virus (HAV)?

<p>Picornavirus (B)</p> Signup and view all the answers

Which type of Hepatitis virus is primarily transmitted through parental routes?

<p>Hepatitis C (HCV) (C)</p> Signup and view all the answers

Which hepatitis virus has a greater than 50% chance of leading to chronic infection?

<p>Hepatitis C (HCV) (C)</p> Signup and view all the answers

What is the mainly utilized treatment for Hepatitis D Virus (HDV)?

<p>Alpha interferon for 12 months (C)</p> Signup and view all the answers

Which Hepatitis virus is noted for having an enteric mode of transmission?

<p>Hepatitis A (HAV) (C)</p> Signup and view all the answers

Which characteristic is NOT associated with Hepatitis E Virus (HEV)?

<p>Causes chronic hepatitis (C)</p> Signup and view all the answers

What is the viral genome type for Hepatitis B (HBV)?

<p>dsDNA (C)</p> Signup and view all the answers

What is the incubation period for Hepatitis B Virus (HBV)?

<p>45-160 days (C)</p> Signup and view all the answers

Which Hepatitis virus is classified as a Deltavirus?

<p>Hepatitis D Virus (C)</p> Signup and view all the answers

Which type of viral genome is associated with Hepatitis C Virus (HCV)?

<p>ssRNA (D)</p> Signup and view all the answers

Which Hepatitis virus has the highest likelihood of leading to chronic hepatitis?

<p>Hepatitis B Virus (A)</p> Signup and view all the answers

What is the mode of transmission for Hepatitis E Virus (HEV)?

<p>Enteric route (B)</p> Signup and view all the answers

What percentage of individuals with Hepatitis D Virus (HDV) superinfection might develop chronic hepatitis?

<p>80% (A)</p> Signup and view all the answers

What treatment is commonly utilized for Hepatitis D Virus (HDV)?

<p>Alpha interferon for 12 months (A)</p> Signup and view all the answers

Which of the following statements about the Hepatitis viruses is true?

<p>Hepatitis A Virus is classified as a Picornavirus. (B)</p> Signup and view all the answers

Flashcards

Liver's role in digestion

The liver produces enzymes, hormones, lectins, and other substances crucial for digestion and blood filtration.

Hepatitis

Inflammation of the liver caused by viral infection, disrupting liver function.

Jaundice

Yellowing of skin and eyes due to impaired liver function, leading to bilirubin buildup.

Bilirubin

Yellow pigment from old red blood cells; liver processes and removes it.

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HAV

Hepatitis A Virus; single-stranded RNA virus infecting the liver.

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Hepatitis Viruses

Group of viruses that infect the liver, causing hepatitis.

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Jaundice in Newborns

Jaundice in newborns is often due to immaturity of the liver's filtering systems, unlike adult jaundice cases which often involve infections or liver disorders.

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Phototherapy

Treatment for infant jaundice that helps the body process bilirubin.

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Liver Sterility

Healthy liver lacks microflora, meaning it's sterile due to its isolation from environment.

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Liver Function

The liver's role in digestion, filtering, hormone, and enzyme production is crucial.

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HAV Transmission

HAV is transmitted through the fecal-oral route, meaning ingestion of contaminated material.

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HAV Symptoms

Mild infection, often 'flu-like' symptoms, possible nausea, vomiting, jaundice (rare).

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HAV Cause of Outbreaks

Often associated with poor hygiene (e.g., food preparation) and poor sewage treatment.

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HBV Transmission

Transmitted through blood, body fluids (semen, saliva), and shared needles or contaminated objects.

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HBV Symptoms

Can range from flu-like symptoms to severe liver damage, potential jaundice, rash, or arthritis

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HBV Chronic Infection

Long-term HBV infection can result in liver cirrhosis and increased risk for liver cancer.

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HCV Transmission

Primarily transmitted through blood (shared needles), but also sexual contact.

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HCV Symptoms

Often subclinical for months/years; symptoms include liver damage (jaundice, malaise, abdominal pain) in later stages.

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HDV Infection

Requires co-infection with HBV because it's an incomplete virus; causes more severe HBV infection

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HEV Transmission

Transmitted through the fecal-oral route, often associated with contaminated water.

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What does the liver do?

The liver produces substances essential for digestion, filters blood, removes old blood cells and toxins.

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What causes jaundice in newborns?

Newborns often develop jaundice because their livers are still developing and haven't fully learned how to remove bilirubin.

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HAV (Hepatitis A Virus)

A non-enveloped, single-stranded RNA virus that belongs to the Picornavirus family.

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What is phototherapy?

A treatment for jaundice in newborns where they are exposed to light to break down bilirubin.

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Why is the liver sterile?

The liver is sterile because it doesn't have contact with the outside environment and doesn't have normal microflora.

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Hepatitis A transmission

HAV is transmitted through the fecal-oral route, meaning ingestion of contaminated material.

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Dane Particle

Another name for the Hepatitis B Virus (HBV), which can be identified in serological tests by the presence of the 'Surface Antigen' in its envelope.

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Surface Antigen

A protein found in the envelope of the Hepatitis B Virus (HBV) that can be detected in serological tests.

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Hepatitis Virus Types

There are five main types of hepatitis viruses: Hepatitis A (HAV), Hepatitis B (HBV), Hepatitis C (HCV), Hepatitis D (HDV), and Hepatitis E (HEV).

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Viral Genome

The genetic material of a virus, which can be either DNA or RNA. Different hepatitis viruses have different types of genomes.

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Chronic Hepatitis

A persistent, long-term infection that can permanently damage the liver.

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Transmission of Hepatitis

The way a virus spreads, which can be through contaminated food/water (enteric), blood contact (parental), or both.

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Hepatitis A (HAV)

A single-stranded RNA virus that is spread through the fecal-oral route.

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Hepatitis B (HBV)

A double-stranded DNA virus that is spread through blood, bodily fluids, and contaminated needles.

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Hepatitis C (HCV)

A single-stranded RNA virus that is primarily spread through blood contact, often through shared needles.

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Hepatitis D (HDV)

A single-stranded RNA virus that needs to co-infect with HBV to survive.

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Hepatitis A (HAV) Transmission

Hepatitis A Virus (HAV) is spread through the fecal-oral route, meaning it's transmitted by ingesting contaminated food or water.

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Hepatitis B (HBV) Transmission

Hepatitis B Virus (HBV) is transmitted through blood, bodily fluids like semen and saliva, and shared needles.

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Hepatitis C (HCV) Transmission

Hepatitis C Virus (HCV) is primarily spread through blood contact, mainly through shared needles.

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Hepatitis D (HDV) Infection

Hepatitis D Virus (HDV) requires a co-infection with Hepatitis B Virus (HBV) to survive, making it more dangerous.

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Hepatitis E (HEV) Transmission

Hepatitis E Virus (HEV) is spread through the fecal-oral route, often through contaminated water.

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What is the difference between Hepatitis A and Hepatitis B?

Hepatitis A is spread through contaminated food and water, while Hepatitis B is spread through blood and bodily fluids.

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Study Notes

Liver Function and Hepatitis

  • Liver is an accessory digestive organ, producing enzymes, hormones, and substances for digestion
  • It also produces lectins for complement activity and filters blood, removing old cells and toxins
  • Liver is sterile due to lack of contact with external environment
  • Hepatitis is liver inflammation due to viral infection, interfering with liver function
  • Jaundice (yellowing of skin/eyes) is a major hepatitis symptom, resulting from liver dysfunction, allowing bilirubin buildup (a yellow pigment) in tissues

Hepatitis Types

  • Different viruses cause different types of hepatitis, varying in structure, transmission, and severity
  • HAV (Hepatitis A Virus): Nonenveloped, single-stranded RNA enterovirus (Picornavirus family)
    • Mild infection, often flu-like symptoms
    • Transmitted via fecal-oral route (contaminated food/water)
    • Outbreaks linked to poor hygiene, e.g., 2013 pomegranate seed outbreak linked to Costco
    • Vaccine available, but many adults are unvaccinated
  • HBV (Hepatitis B Virus) Enveloped DNA virus (Hepadnaviridae)
    • More severe than HAV, potentially chronic leading to cirrhosis and liver cancer
    • Transmission via blood, body fluids (semen, saliva, etc.), needles, razors, mother to child
    • Vaccine recommended for children and high-risk adults
  • HCV (Hepatitis C Virus): RNA virus (Flaviviridae)
    • Often subclinical (no symptoms) for months/years.
    • Chronic infection common, leading to serious liver damage and potentially liver transplant in severe cases
    • Transmitted via blood-to-blood contact (needles)
    • No vaccine available
  • HDV (Hepatitis D Virus)
    • Incomplete virus, requiring HBV infection to replicate
    • Co-infection with HBV, resulting in severe HBV infection
    • HBV Vaccine protects against HDV
  • HEV (Hepatitis E Virus)
    • Relatively mild infection, transmitted through the fecal-oral route
    • Usually seen in areas with poor sanitation
    • Self-limiting infection
    • No vaccine available

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