Podcast
Questions and Answers
A patient receiving heparin develops thrombocytopenia two days after the start of treatment. Which characteristic is LEAST likely to be associated with this patient's condition?
A patient receiving heparin develops thrombocytopenia two days after the start of treatment. Which characteristic is LEAST likely to be associated with this patient's condition?
- Spontaneous platelet count normalization despite continued heparin exposure.
- Requirement for immediate cessation of heparin therapy. (correct)
- Non-immune mediated mechanism of platelet reduction.
- Absence of detectable anti-PF4 antibodies.
A patient is diagnosed with HIT type 2. Which course of action is MOST appropriate?
A patient is diagnosed with HIT type 2. Which course of action is MOST appropriate?
- Begin platelet transfusions to correct the thrombocytopenia.
- Continue heparin therapy while closely monitoring platelet counts for stabilization.
- Immediately discontinue heparin and initiate a non-heparin anticoagulant. (correct)
- Administer corticosteroids to suppress the immune response.
A patient presents with a suspected heparin-induced thrombocytopenia (HIT). Initial laboratory results show a mildly reduced platelet count that stabilizes within 48 hours of continued heparin therapy. Which of the following BEST explains this scenario?
A patient presents with a suspected heparin-induced thrombocytopenia (HIT). Initial laboratory results show a mildly reduced platelet count that stabilizes within 48 hours of continued heparin therapy. Which of the following BEST explains this scenario?
- The patient is likely experiencing HIT type 2, necessitating immediate intervention.
- The patient's presentation is atypical and requires further investigation to rule out other causes of thrombocytopenia.
- The patient is likely experiencing HIT type 1, which typically resolves spontaneously. (correct)
- The patient is likely experiencing disseminated intravascular coagulation (DIC).
A patient with a history of heparin exposure develops new onset thrombosis and thrombocytopenia. Which diagnostic finding would STRONGLY suggest HIT Type 2 over HIT Type 1?
A patient with a history of heparin exposure develops new onset thrombosis and thrombocytopenia. Which diagnostic finding would STRONGLY suggest HIT Type 2 over HIT Type 1?
In the context of Heparin-Induced Thrombocytopenia (HIT), what is the primary immunological mechanism driving the pathophysiology of HIT Type 2?
In the context of Heparin-Induced Thrombocytopenia (HIT), what is the primary immunological mechanism driving the pathophysiology of HIT Type 2?
Which of the following scenarios would necessitate the STRONGEST consideration for immediate testing for Heparin-Induced Thrombocytopenia (HIT)?
Which of the following scenarios would necessitate the STRONGEST consideration for immediate testing for Heparin-Induced Thrombocytopenia (HIT)?
A patient is suspected of having HIT type II. Which of the following test results would be MOST conclusive in confirming this diagnosis?
A patient is suspected of having HIT type II. Which of the following test results would be MOST conclusive in confirming this diagnosis?
A patient with confirmed HIT Type II requires urgent anticoagulation for a newly diagnosed pulmonary embolism. Which of the following anticoagulants is MOST appropriate to initiate?
A patient with confirmed HIT Type II requires urgent anticoagulation for a newly diagnosed pulmonary embolism. Which of the following anticoagulants is MOST appropriate to initiate?
What is the MOST significant long-term risk associated with Heparin-Induced Thrombocytopenia type II (HIT Type II)?
What is the MOST significant long-term risk associated with Heparin-Induced Thrombocytopenia type II (HIT Type II)?
Which statement accurately differentiates between Heparin-Induced Thrombocytopenia type I (HIT Type I) and type II (HIT Type II)?
Which statement accurately differentiates between Heparin-Induced Thrombocytopenia type I (HIT Type I) and type II (HIT Type II)?
Flashcards
HIT Type 1
HIT Type 1
Non-immune mediated, occurring within the first 2 days of heparin use, and does not typically require specific management. Platelet count normalizes with continuous heparin therapy.
HIT Type 2
HIT Type 2
Immune-mediated, typically occurring 4-10 days after heparin exposure, involving autoantibody formation against platelet factor 4, which can lead to venous and arterial thrombosis.
Study Notes
HIT Type 1
- Occurs within the first 2 days of heparin use.
- It is a non-immune disorder.
- Management is not required.
- Platelet count normalizes even with continuous heparin therapy.
HIT Type 2
- It is immune-mediated.
- Occurs 4-10 days after exposure to Heparin.
- Autoantibody formation against factor 4 is the cause.
- Causes both venous and arterial thrombosis.
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