Hepadnaviridae and Hepatitis B Virus Quiz
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Questions and Answers

What is the target cell of Hepadnaviridae?

  • Fibroblasts
  • Lymphocytes
  • Epithelial cells of bile ducts
  • Hepatocytes (correct)

    • What is the function of the protein encoded by ORF P?

  • Expression of HBcAg codon
  • RNA/DNA-dependent DNA polymerase and RNase H activity (correct)
  • Secretion of HBeAg
  • Transactivating propriety

    • Which gene encodes the regulatory protein with transactivating propriety?

  • ORF C
  • ORF X (correct)
  • ORF P
  • ORF S

    • Which of the following is NOT a morphologically distinct form of HBV?

    <p>Spherical particles with a diameter of 40 nm</p> Signup and view all the answers

    What is responsible for the chronic hepatopathy and its outcomes in liver cirrhosis and hepatocellular carcinoma?

    <p>The accumulation of damage produced by the fibrotic repair</p> Signup and view all the answers

    What do RT nucleosidic inhibitors do?

    <p>Inhibit the reverse transcriptase enzyme</p> Signup and view all the answers

    What is the rate of mutation introduced by RT in the HBV genome?

    <p>1 mutation / 105 nucleotide</p> Signup and view all the answers

    Which type of individuals are more likely to have chronic HBV infection?

    <p>Immune-compromised individuals</p> Signup and view all the answers

    What is the function of Interferon α 2A peg and Interferon α 2B in HBV treatment?

    <p>They target only replicating viruses and do not eradicate latently integrated or non replicating episomal viral genomes</p> Signup and view all the answers

    What is the significance of the presence of HBeAg in a patient with HBV infection?

    <p>It is a marker for the presence of active virus replication</p> Signup and view all the answers

    What is the incubation period for HBV infection?

    <p>10-12 weeks</p> Signup and view all the answers

    Which of the following is a viral reservoir for HBV transmission?

    <p>Percutaneous permucosal transmission</p> Signup and view all the answers

    What is the function of HBsAg in the HBV vaccine?

    <p>It acts as an adjuvant</p> Signup and view all the answers

    Which cell type(s) can be infected by HBV in patients chronically infected?

    <p>Monocytes, lymphocytes, fibroblasts, and epithelial cells of bile ducts</p> Signup and view all the answers

    Which gene encodes the protein that is secreted by the cell and accumulates in the serum?

    <p>ORF S</p> Signup and view all the answers

    What is the function of the protein encoded by HBX?

    <p>It is a regulatory protein with transactivating property</p> Signup and view all the answers

    What is the morphology of non-infectious HBV particles?

    <p>Spherical particles with a diameter of 20 nm</p> Signup and view all the answers

    What is the role of cccDNA in HBV replication?

    <p>It remains in the nucleus of the host cell as a template for viral RNA synthesis</p> Signup and view all the answers

    What is the mechanism of HBV-induced liver damage?

    <p>Host-mediated damage from CTL and fibrotic repair</p> Signup and view all the answers

    Which antiviral drug is an RT nucleotidic inhibitor?

    <p>Tenofovir</p> Signup and view all the answers

    Which type of infection is HBV?

    <p>Chronic</p> Signup and view all the answers

    What is the function of HBsAg in the HBV vaccine?

    <p>It is the surface antigen adsorbed on aluminum hydroxide as adjuvant</p> Signup and view all the answers

    What is the significance of the presence of HBsAb in a patient's blood?

    <p>It indicates protection from infection or immunization</p> Signup and view all the answers

    Which gene in the HBV genome encodes the protein that is not incorporated in virions, but is secreted by the cell and accumulates in the serum?

    <p>ORF S</p> Signup and view all the answers

    Which cell types can HBV infect in patients chronically infected?

    <p>Epithelial cells of bile ducts and hepatocytes</p> Signup and view all the answers

    Which gene in the HBV genome encodes the regulatory protein with transactivating propriety that can associate with cellular p53, involved in the occurrence of liver carcinoma?

    <p>ORF X</p> Signup and view all the answers

    Which of the following is a morphologically distinct form of HBV?

    <p>Spherical particles with a diameter of 20 nm</p> Signup and view all the answers

    What is responsible for the genetic variability of HBV?

    <p>RT introducing mutations</p> Signup and view all the answers

    What is the mechanism of HBV-induced liver damage?

    <p>Host-mediated cytolytic action of CTL</p> Signup and view all the answers

    Which antiviral drug is a nucleosidic inhibitor of RT?

    <p>Lamivudine</p> Signup and view all the answers

    Which gene in the HBV genome has two in-frame start codons, enabling the expression of HBeAg and HBcAg?

    <p>ORF C</p> Signup and view all the answers

    What is the function of the protein encoded by ORF P in HBV?

    <p>It encodes the reverse transcriptase</p> Signup and view all the answers

    Which cell types can HBV infect in patients chronically infected?

    <p>Hepatocytes only</p> Signup and view all the answers

    What is the main mode of transmission for HBV?

    <p>Percutaneous or permucosal exposure to infected blood or fluids</p> Signup and view all the answers

    Which antibody indicates protection from HBV infection?

    <p>HBsAb</p> Signup and view all the answers

    What is the cause for transformation associated with primary hepatocellular carcinoma (HCC) in HBV?

    <p>Inflammatory alterations</p> Signup and view all the answers

    Which of the following is NOT a mechanism of HBV-induced liver damage?

    <p>Stimulation of P53 expression</p> Signup and view all the answers

    What is the morphology of infectious HBV particles?

    <p>40-45 nm complete virions (Dane particles)</p> Signup and view all the answers

    What is the function of non-infectious HBV particles?

    <p>To be highly immunogenic</p> Signup and view all the answers

    Which antiviral drug is a nucleosidic inhibitor of HBV RT?

    <p>Lamivudine</p> Signup and view all the answers

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