23 Questions
What is the primary function of the Coagulation System?
To form a stable insoluble plug
What is the consequence of an imbalance in the Coagulation System?
Unstable coagulation leading to thrombosis or hemorrhaging
What is the role of the Fibrinolytic System in hemostasis?
To dissolve blood clots
What is the initial response of the Vascular System following an injury?
Vasoconstriction of the arterioles
What is the ultimate goal of the three stages of Hemostasis?
To achieve a balance between bleeding and clotting
What is the result of the failure or deficiencies in any of the five systems involved with hemostasis?
Varying degrees of uncontrolled hemorrhaging or clotting
What is the primary function of platelets in primary hemostasis?
To form a temporary plug to arrest bleeding
What is the primary function of the coagulation factors in the coagulation system?
To form a fibrin mesh or clot to stop bleeding
What is the purpose of the cofactors in the coagulation cascade?
To facilitate the reaction between coagulation factors
What is the purpose of Factor XIII in secondary hemostasis?
To stabilize fibrin
What is the origin of the fibrin that reinforces and stabilizes the primary hemostatic plug?
Soluble plasma proteins
What is the correct sequence of stages in the formation of a primary hemostatic plug?
Adhesion, Secretion, Aggregation, Stabilization
What is the outcome of the process of blood clotting in response to vascular injury?
A solid state of blood
What is the term for the slow contraction or retraction and lysis of the clot?
Secondary hemostasis
What are the two pathways that activate Factor X to Xa?
Intrinsic and extrinsic pathways
What is the term for the interaction between the vasculature and platelets that forms a temporary plug?
Primary hemostasis
What is the significance of the Roman numerals in the naming of coagulation factors?
They indicate the order of discovery
What is the primary function of fibrinolysis?
To dissolve fibrin clots
What is the role of protein C and S in the coagulation cascade?
To inhibit coagulation
Which laboratory test assesses platelet plug formation and capillary integrity?
Bleeding Time (BT)
What is the primary function of the coagulation inhibition system?
To provide a balance to clotting mechanisms
What is the role of macrophages in fibrinolysis?
To clear fibrin degradation products from circulation
What is the primary mechanism of action of plasmin in fibrinolysis?
Enzymatically attacking the fibrin molecule
Learn about the stages of hemostasis, including secondary hemostasis, and how coagulation factors form fibrin in response to injury. Discover how fibrin is stabilized and the consequences of deficiencies in hemostasis systems.
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