Hemostasis: Stages and Coagulation

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What is the primary function of the Coagulation System?

To promote bleeding

To dissolve blood clots

To regulate vasoconstriction

To form a stable insoluble plug (correct)

What is the consequence of an imbalance in the Coagulation System?

Enhanced platelet production

Uncontrolled inflammation

Unstable coagulation leading to thrombosis or hemorrhaging (correct)

Excessive bleeding

What is the role of the Fibrinolytic System in hemostasis?

To regulate vasoconstriction

To dissolve blood clots (correct)

To promote platelet aggregation

To form a stable insoluble plug

What is the initial response of the Vascular System following an injury?

Vasoconstriction of the arterioles Signup and view all the answers

What is the ultimate goal of the three stages of Hemostasis?

To achieve a balance between bleeding and clotting Signup and view all the answers

What is the result of the failure or deficiencies in any of the five systems involved with hemostasis?

Varying degrees of uncontrolled hemorrhaging or clotting Signup and view all the answers

What is the primary function of platelets in primary hemostasis?

To form a temporary plug to arrest bleeding Signup and view all the answers

What is the primary function of the coagulation factors in the coagulation system?

To form a fibrin mesh or clot to stop bleeding Signup and view all the answers

What is the purpose of the cofactors in the coagulation cascade?

To facilitate the reaction between coagulation factors Signup and view all the answers

What is the purpose of Factor XIII in secondary hemostasis?

To stabilize fibrin Signup and view all the answers

What is the origin of the fibrin that reinforces and stabilizes the primary hemostatic plug?

Soluble plasma proteins Signup and view all the answers

What is the correct sequence of stages in the formation of a primary hemostatic plug?

Adhesion, Secretion, Aggregation, Stabilization Signup and view all the answers

What is the outcome of the process of blood clotting in response to vascular injury?

A solid state of blood Signup and view all the answers

What is the term for the slow contraction or retraction and lysis of the clot?

Secondary hemostasis Signup and view all the answers

What are the two pathways that activate Factor X to Xa?

Intrinsic and extrinsic pathways Signup and view all the answers

What is the term for the interaction between the vasculature and platelets that forms a temporary plug?

Primary hemostasis Signup and view all the answers

What is the significance of the Roman numerals in the naming of coagulation factors?

They indicate the order of discovery Signup and view all the answers

What is the primary function of fibrinolysis?

To dissolve fibrin clots Signup and view all the answers

What is the role of protein C and S in the coagulation cascade?

To inhibit coagulation Signup and view all the answers

Which laboratory test assesses platelet plug formation and capillary integrity?

Bleeding Time (BT) Signup and view all the answers

What is the primary function of the coagulation inhibition system?

To provide a balance to clotting mechanisms Signup and view all the answers

What is the role of macrophages in fibrinolysis?

To clear fibrin degradation products from circulation Signup and view all the answers

What is the primary mechanism of action of plasmin in fibrinolysis?

Enzymatically attacking the fibrin molecule Signup and view all the answers