23 Questions
Heme is converted to bilirubin in _______.
macrophages
Which of the following designations represents HbF?
$\alpha2\gamma2$
Beta Thalasemia normally 2 beta globin chains bind to chromosome 11. How many deficient betas are present in β-thalasemia major?
Two
Which condition results in excess absorption of iron due to a genetic disorder?
Hemochromatosis
What is the cause of sickle cell disease?
Clumping of red blood cells
What is the composition of adult Hb A?
$\alpha2\beta2$
What is the manifestation of three deficient alpha globin chains in Alpha Thalasemia?
Severe anemia
What causes sickle cell disease to be more severe?
Increased oxygen tension
Excess unconjugated bilirubin in blood can diffuse to the basal ganglia causing toxic encephalopathy in which condition?
Hemolytic Anemia
What is the cause of prolonged bile duct obstructions?
Bile stones
Which condition is characterized by reduced uptake of unconjugated bilirubin from circulation?
Hemolytic Anemia
Which organ does ferritin/iron go to for storage in the blood circulation process?
Liver
What is the main source of heme in the breakdown of hemoglobin?
Mature RBCs
What is the end product of heme degradation via heme oxygenase?
Biliverdin
What causes jaundice due to hemolysis?
Increased bilirubin in blood
What is the classification of jaundice with normal feces and urine?
Hemolytic Jaundice (pre-hepatic)
What causes yellow skin and sclerae in jaundice?
Increased bilirubin in blood
What is the end product of biliverdin via biliverdin reductase?
Bilirubin
What is the cause of jaundice with excretion of bilirubin due to liver damage?
Increased bilirubin in blood
What is the primary function of macrophages in the breakdown of hemoglobin?
Break down heme from globin
What causes jaundice due to excretion of bilirubin?
Increased bilirubin in blood
What is the consequence of bile duct obstruction in jaundice?
Yellow skin and sclerae
What is the cause of jaundice due to liver damage?
Increased bilirubin in blood
Test your knowledge of the breakdown of hemoglobin and the formation of bilirubin with this quiz. Explore the role of macrophages, heme, iron, and biliverdin in the process, and understand how bilirubin is formed and transported in the body.
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