Hemoglobin Breakdown and Bilirubin Formation Quiz
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Questions and Answers

Heme is converted to bilirubin in _______.

  • erythrocytes
  • macrophages (correct)
  • hepatocytes
  • kidney cells

    • Which of the following designations represents HbF?

  • $\alpha2\gamma2$ (correct)
  • $\alpha2\beta2$
  • $\delta2\beta2$
  • $\alpha2\delta2$

    • Beta Thalasemia normally 2 beta globin chains bind to chromosome 11. How many deficient betas are present in β-thalasemia major?

  • Four
  • One
  • Three
  • Two (correct)

    • Which condition results in excess absorption of iron due to a genetic disorder?

    <p>Hemochromatosis</p> Signup and view all the answers

    What is the cause of sickle cell disease?

    <p>Clumping of red blood cells</p> Signup and view all the answers

    What is the composition of adult Hb A?

    <p>$\alpha2\beta2$</p> Signup and view all the answers

    What is the manifestation of three deficient alpha globin chains in Alpha Thalasemia?

    <p>Severe anemia</p> Signup and view all the answers

    What causes sickle cell disease to be more severe?

    <p>Increased oxygen tension</p> Signup and view all the answers

    Excess unconjugated bilirubin in blood can diffuse to the basal ganglia causing toxic encephalopathy in which condition?

    <p>Hemolytic Anemia</p> Signup and view all the answers

    What is the cause of prolonged bile duct obstructions?

    <p>Bile stones</p> Signup and view all the answers

    Which condition is characterized by reduced uptake of unconjugated bilirubin from circulation?

    <p>Hemolytic Anemia</p> Signup and view all the answers

    Which organ does ferritin/iron go to for storage in the blood circulation process?

    <p>Liver</p> Signup and view all the answers

    What is the main source of heme in the breakdown of hemoglobin?

    <p>Mature RBCs</p> Signup and view all the answers

    What is the end product of heme degradation via heme oxygenase?

    <p>Biliverdin</p> Signup and view all the answers

    What causes jaundice due to hemolysis?

    <p>Increased bilirubin in blood</p> Signup and view all the answers

    What is the classification of jaundice with normal feces and urine?

    <p>Hemolytic Jaundice (pre-hepatic)</p> Signup and view all the answers

    What causes yellow skin and sclerae in jaundice?

    <p>Increased bilirubin in blood</p> Signup and view all the answers

    What is the end product of biliverdin via biliverdin reductase?

    <p>Bilirubin</p> Signup and view all the answers

    What is the cause of jaundice with excretion of bilirubin due to liver damage?

    <p>Increased bilirubin in blood</p> Signup and view all the answers

    What is the primary function of macrophages in the breakdown of hemoglobin?

    <p>Break down heme from globin</p> Signup and view all the answers

    What causes jaundice due to excretion of bilirubin?

    <p>Increased bilirubin in blood</p> Signup and view all the answers

    What is the consequence of bile duct obstruction in jaundice?

    <p>Yellow skin and sclerae</p> Signup and view all the answers

    What is the cause of jaundice due to liver damage?

    <p>Increased bilirubin in blood</p> Signup and view all the answers

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