22 Questions
Which of the following methods does NOT directly account for thromboembolization during hemocompatibility testing?
Gravimetric analysis of thrombus mass
Which of the following is NOT a method for evaluating hemocompatibility in vivo?
Gross and microscopic analysis of the device
Which of the following statements about thrombosis analysis is TRUE?
Histological analysis of distal organs looks for evidence of thromboembolization.
In evaluating the hemocompatibility of a novel polymeric material for extracorporeal membrane oxygenation (ECMO), which of the following would be the LEAST useful?
Gross and microscopic analysis of the device
Which of the following is NOT a method for blood testing mentioned in the text?
Analysis for factors specific to endothelial activation
Which of the following statements about the ePTFE control is TRUE?
It is a vascular graft used as a control in hemocompatibility testing.
Which of the following is NOT a primary mechanism associated with thrombus formation initiated from contact between blood and artificial materials?
Activation of the extrinsic coagulation pathway
Which of the following is NOT a concern for blood-contacting devices?
Activation of the extrinsic coagulation pathway
What is the definition of hemocompatibility according to the text?
The property of a material that permits it to function in contact with blood without inducing adverse reactions
Which of the following is NOT mentioned as a potential cause of hemolysis in the text?
Shear stress in the bloodstream
What is the definition of thrombogenicity?
The extent to which a device induces adverse responses when employed in its intended use configuration
Which of the following pathways is mentioned in the text as potentially being activated by a blood-contacting device?
Intrinsic coagulation pathway
Which of the following scenarios could lead to an incorrect conclusion about a device's hemocompatibility?
A large thrombus forms but detaches (embolizes) from the device.
What is one of the key considerations for biomaterial interaction (BMI) assessment?
The type of blood and handling methods can strongly influence BMI.
Which of the following is NOT a factor contributing to the coagulation of blood, according to Virchow's triad?
Presence of anticoagulants
What is one advantage of in vitro hemocompatibility testing over in vivo testing?
It avoids the need for costly animal models.
Which of the following statements about in vitro hemocompatibility testing is NOT true?
It allows for the assessment of activation-inhibiting functions of endothelial cells.
What is one of the goals of device testing in hemocompatibility evaluation?
To predict whether a medical device presents potential harm to the patient under simulated clinical use.
What is one advantage of in vitro hemocompatibility testing compared to in vivo testing?
It enables worst-case scenario testing where activation products accumulate without clearance.
What is one of the key considerations for biomaterial selection in hemocompatibility testing?
Selecting materials with the most appropriate mechanical properties.
What is one advantage of in vitro hemocompatibility testing?
It allows for high replication testing using the same batch of blood and at the same time.
Which of the following statements about in vitro hemocompatibility testing is true?
It does not allow for the assessment of activation-inhibiting functions of endothelial cells.
Learn about the methods used for evaluating hemocompatibility of tubular devices, such as the GORE® PROPATEN® Vascular Graft, through ex vivo and in vivo testing. Topics include thrombosis, gross and microscopic analysis, gravimetric analysis of thrombus mass, and histological analysis of distal organs.
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