Hemocompatibility Testing Methods for Tubular Devices

Play an AI-generated podcast conversation about this lesson

Which of the following methods does NOT directly account for thromboembolization during hemocompatibility testing?

Histological analysis of distal organs
Angiography and intravascular ultrasound
Gravimetric analysis of thrombus mass (correct)
Percent occlusion/patency assessment

Which of the following is NOT a method for evaluating hemocompatibility in vivo?

Analysis for factors specific to complement activation
Histological analysis of distal organs
Hematology to assess cells and clotting time
Gross and microscopic analysis of the device (correct)

Which of the following statements about thrombosis analysis is TRUE?

Scanning electron microscopy (SEM) is not used for thrombosis analysis.
Percent occlusion/patency cannot be assessed using imaging methods.
Histological analysis of distal organs looks for evidence of thromboembolization. (correct)
Gravimetric analysis of thrombus mass accounts for embolization.

In evaluating the hemocompatibility of a novel polymeric material for extracorporeal membrane oxygenation (ECMO), which of the following would be the LEAST useful?

Gross and microscopic analysis of the device (C) Signup and view all the answers

Which of the following is NOT a method for blood testing mentioned in the text?

Analysis for factors specific to endothelial activation (A) Signup and view all the answers

Which of the following statements about the ePTFE control is TRUE?

It is a vascular graft used as a control in hemocompatibility testing. (B) Signup and view all the answers

Which of the following is NOT a primary mechanism associated with thrombus formation initiated from contact between blood and artificial materials?

Activation of the extrinsic coagulation pathway (A) Signup and view all the answers

Which of the following is NOT a concern for blood-contacting devices?

Activation of the extrinsic coagulation pathway (B) Signup and view all the answers

What is the definition of hemocompatibility according to the text?

The property of a material that permits it to function in contact with blood without inducing adverse reactions (B) Signup and view all the answers

Which of the following is NOT mentioned as a potential cause of hemolysis in the text?

Shear stress in the bloodstream (A) Signup and view all the answers

What is the definition of thrombogenicity?

The extent to which a device induces adverse responses when employed in its intended use configuration (D) Signup and view all the answers

Which of the following pathways is mentioned in the text as potentially being activated by a blood-contacting device?

Intrinsic coagulation pathway (A) Signup and view all the answers

Which of the following scenarios could lead to an incorrect conclusion about a device's hemocompatibility?

A large thrombus forms but detaches (embolizes) from the device. (C) Signup and view all the answers

What is one of the key considerations for biomaterial interaction (BMI) assessment?

The type of blood and handling methods can strongly influence BMI. (A) Signup and view all the answers

Which of the following is NOT a factor contributing to the coagulation of blood, according to Virchow's triad?

Presence of anticoagulants (D) Signup and view all the answers

What is one advantage of in vitro hemocompatibility testing over in vivo testing?

It avoids the need for costly animal models. (B) Signup and view all the answers

Which of the following statements about in vitro hemocompatibility testing is NOT true?

It allows for the assessment of activation-inhibiting functions of endothelial cells. (A) Signup and view all the answers

What is one of the goals of device testing in hemocompatibility evaluation?

To predict whether a medical device presents potential harm to the patient under simulated clinical use. (B) Signup and view all the answers

What is one advantage of in vitro hemocompatibility testing compared to in vivo testing?

It enables worst-case scenario testing where activation products accumulate without clearance. (A) Signup and view all the answers

What is one of the key considerations for biomaterial selection in hemocompatibility testing?

Selecting materials with the most appropriate mechanical properties. (C) Signup and view all the answers

What is one advantage of in vitro hemocompatibility testing?

It allows for high replication testing using the same batch of blood and at the same time. (D) Signup and view all the answers

Which of the following statements about in vitro hemocompatibility testing is true?

It does not allow for the assessment of activation-inhibiting functions of endothelial cells. (C) Signup and view all the answers