Hematopoiesis Course Overview

<p>Common lymphoid progenitors (CLP) (B)</p> Signup and view all the answers

<p>They may lead to differentiation into fewer cell types. (D)</p> Signup and view all the answers

<p>6 weeks (A)</p> Signup and view all the answers

<p>Bone marrow (A)</p> Signup and view all the answers

<p>Haemangioblasts (C)</p> Signup and view all the answers

<p>1 in 20 million (C)</p> Signup and view all the answers

<p>Ribs (B)</p> Signup and view all the answers

<p>Migration to bone marrow (C)</p> Signup and view all the answers

<p>Mid fetal life (D)</p> Signup and view all the answers

<p>Appears red and contains no fat (A)</p> Signup and view all the answers

<p>Maturation (C)</p> Signup and view all the answers

<p>Transforming growth factor β (TGF-β) (D)</p> Signup and view all the answers

<p>Mobilization (D)</p> Signup and view all the answers

<p>Burst forming unit–erythroid (BFU-E) (A)</p> Signup and view all the answers

<p>Interleukin-3 (IL-3) (D)</p> Signup and view all the answers

<p>Terminal differentiation (B)</p> Signup and view all the answers

<p>Erythron (D)</p> Signup and view all the answers

<p>Neovascularization (D)</p> Signup and view all the answers

A cell with the ability to self-renew and differentiate into all blood cell types.

The ability of a stem cell to create identical copies of itself, ensuring a constant supply of stem cells.

A cell that differentiates into lymphoid blood cells.

A cell that differentiates into myeloid blood cells.

A stem cell that can differentiate into several different cell types, but not all.

Hematopoietic stem cell descendants commit to differentiation, migration, or apoptosis; this commitment process occurs through stages influenced by TGF-β.

HSC descendants commit to differentiation, migration, or apoptosis, a process influenced by transforming growth factor-beta (TGF-β).

Cytokines, like TGF-β, play a key role in influencing the commitment of hematopoietic stem cell descendants to differentiation, migration, or apoptosis.

The majority of HSC are typically in a resting state, known as quiescence, residing in the G0 phase of the cell cycle.

HSC can move from the bone marrow into circulation, a process called mobilization, controlled by specific cytokines.

HSC can return from circulation back into the bone marrow, a process called homing.

The burst forming unit–erythroid (BFU-E) is the earliest identified progenitor cell committed to the erythroid lineage.

The burst forming unit–erythroid (BFU-E) requires interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), erythropoietin (EPO), and other factors for proliferation, prevention of apoptosis, and maturation.

Hematopoiesis, the process of blood cell formation, initially occurs in the yolk sac.

The aorta-gonad-mesonephros (AGM) region is where blood cell precursors migrate to around day 28-40 of gestation.

The liver becomes the primary site of hematopoiesis starting around 6 weeks of gestation.

Bone marrow becomes the major site of hematopoiesis around the 24th week of gestation.

The bone marrow microenvironment provides the necessary conditions for hematopoiesis, including growth factors and support cells.

At puberty, hematopoietic marrow is primarily found in the central skeleton, thorax, vertebrae, skull, pelvic bone, and upper ends of long bones.

As we age, bone marrow starts to be replaced by fatty tissue, with the exception of the areas mentioned in the previous card.

Hematopoietic stem cells are very rare, estimated to be about 1 in 20 million nucleated cells in bone marrow.