Hematology Overview Quiz

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Questions and Answers

What condition is indicated by anuria?

  • Normal urine output
  • Severely reduced or complete absence of urine output (correct)
  • Involuntary urination at night
  • Excessive urine production

What color of urine is associated with elevated bilirubin levels?

  • Orange (correct)
  • Red to Brown
  • White
  • Clear

How is bilirubin formed in the body?

  • From the breakdown of proteins
  • From kidney filtration
  • From the destruction of red blood cells (correct)
  • From muscle metabolism

What term describes a urine output of less than 400 mL/day?

<p>Oliguria (B)</p> Signup and view all the answers

What is the preferred specimen volume for urine testing?

<p>50 mL (B)</p> Signup and view all the answers

What does a positive bilirubin test indicate?

<p>Early signs of liver disease or bile obstruction (B)</p> Signup and view all the answers

What urine appearance is associated with amorphous phosphates?

<p>White, cloudy appearance (B)</p> Signup and view all the answers

What term refers to involuntary night-time urination?

<p>Enuresis (B)</p> Signup and view all the answers

What is the primary function of leukocytes in the body?

<p>Aid in immune response (C)</p> Signup and view all the answers

Which component is found in the structure of leukocytes?

<p>Globulin (D)</p> Signup and view all the answers

What is the lifespan of red blood cells (RBCs)?

<p>120 days (B)</p> Signup and view all the answers

Which type of white blood cells are characterized by lobulated nuclei?

<p>Neutrophils (C)</p> Signup and view all the answers

What characterizes immature red blood cells (reticulocytes)?

<p>They exhibit a blue network when stained. (D)</p> Signup and view all the answers

Which statement describes the composition of arteries and veins in terms of blood color?

<p>Arterial blood is brighter than venous blood. (B)</p> Signup and view all the answers

What is a common feature of granular white blood cells?

<p>They contain granules with digestive enzymes. (B)</p> Signup and view all the answers

Which of the following is an example of agranular white blood cells?

<p>Lymphocytes (C)</p> Signup and view all the answers

What is the optimal temperature for refrigeration of urine samples if analysis cannot be completed within 1 hour?

<p>4-5 degrees Celsius (A)</p> Signup and view all the answers

Which type of urine sample is best for urinalysis?

<p>Clean-catch midstream urine (B)</p> Signup and view all the answers

What must be checked first when handling urine samples?

<p>Integrity of the sample (D)</p> Signup and view all the answers

How should reagent strips be stored to ensure proper functionality?

<p>With desiccant and cap (C)</p> Signup and view all the answers

What is one characteristic of a 24-hour urine specimen collection?

<p>First urination is discarded and the second is collected (D)</p> Signup and view all the answers

What is the primary role of quality control (QC) in urine testing procedures?

<p>To calibrate equipment and ensure accuracy (C)</p> Signup and view all the answers

What byproduct indicates muscle destruction in urine tests?

<p>Myoglobin (B)</p> Signup and view all the answers

What would indicate the presence of Pseudomonas bacteria in a urinary tract infection?

<p>Fluorescence (glowing) under UV light (A)</p> Signup and view all the answers

What is the primary reason for treating all specimens as potentially infectious?

<p>Due to the overuse of antibiotics (D)</p> Signup and view all the answers

Which item is considered the most important piece of personal protective equipment (PPE) in the medical laboratory?

<p>Gloves (D)</p> Signup and view all the answers

Which of the following represents a portal of exit for pathogens?

<p>Ingestion (C)</p> Signup and view all the answers

What is the proper sequence for doffing personal protective equipment?

<p>Gloves, lab gown, goggles, mask, hair net, shoe cover (A)</p> Signup and view all the answers

What is the mode of transmission for opportunistic pathogens?

<p>Direct contact, air, or vectors (B)</p> Signup and view all the answers

What should be done with gloves after completing work with potentially infectious materials?

<p>Remove them and wash hands (A)</p> Signup and view all the answers

Why should laboratory professionals avoid eating or applying makeup while working with specimens?

<p>It poses a risk of contaminating specimens (D)</p> Signup and view all the answers

What is the purpose of using a mask in a laboratory setting?

<p>To protect against droplets from sneezing and coughing (A)</p> Signup and view all the answers

What are the three products released into the bloodstream when fat is metabolized?

<p>Acetone, Acetoacetic acid, Beta-hydroxybutyric acid (B)</p> Signup and view all the answers

Which condition is indicated by the presence of leukocytes in urine?

<p>Urinary tract infection (C)</p> Signup and view all the answers

What does a positive nitrite test in urine generally indicate?

<p>Presence of bacteria (B)</p> Signup and view all the answers

What is the normal pH range for urine?

<p>4.6-8.0 (D)</p> Signup and view all the answers

What is microalbuminuria?

<p>Chronic presence of small amounts of albumin in urine (D)</p> Signup and view all the answers

What is the primary substance detected by leukocyte esterase reagent strips?

<p>Neutrophils (D)</p> Signup and view all the answers

Which of the following conditions can lead to ketonuria?

<p>Diabetes mellitus (D)</p> Signup and view all the answers

What is the primary purpose of zygote banking?

<p>To preserve zygotes prior to transfer to a woman's womb (C)</p> Signup and view all the answers

What kidney issue correlates with the appearance of squamous epithelial cells in a urine sample?

<p>Shed cells from the lining of the urinary tract (A)</p> Signup and view all the answers

Which of the following describes allografts?

<p>Transplants performed between two subjects of the same species (A)</p> Signup and view all the answers

What is the temperature used for freezing in cryobanking?

<p>-196 C (B)</p> Signup and view all the answers

Which method of cloning involves separating a very early embryo into individual cells?

<p>Artificial Embryo Twinning (C)</p> Signup and view all the answers

What is Short-Term Cryobanking primarily used for?

<p>For preservation of sperm or zygote for less than a year (C)</p> Signup and view all the answers

Which of the following organs is most commonly transplanted?

<p>Kidneys (A)</p> Signup and view all the answers

What is the primary goal of sex selection?

<p>To control the gender of the offspring while in the womb (C)</p> Signup and view all the answers

Which cloning method was first performed in 1997?

<p>Somatic Cell Nuclear Transfer (SCNT) (C)</p> Signup and view all the answers

Flashcards

Clean-catch midstream urine

The best sample for urinalysis, collected by urinating into a sterile container after cleaning the genital area.

Post prandial specimen

A urine sample collected after a meal, used in glucose tolerance testing.

24-hour urine collection

Collecting urine over a 24-hour period, discarding the first urination, and refrigerating the rest.

Urinalysis

A type of urine analysis that examines the physical, chemical, and microscopic properties of urine.

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Myoglobin

A byproduct of muscle destruction, sometimes seen in urine samples.

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Pseudomonas infection

A urinary tract infection (UTI) caused by Pseudomonas bacteria, characterized by blue or green urine.

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Timed specimen

A type of urine analysis where the sample is collected at specific times to measure a particular substance.

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Post-prandial urine specimen

A urine sample collected on a patient who has just eaten, typically used for glucose tolerance tests.

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Anuria

The absence or severely reduced amount of urine production, often indicating a serious condition such as end-stage renal disease, acute kidney injury, dehydration, or blockage in the urinary tract.

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Oliguria

Low urine output, generally less than 400 mL per day. It can be a sign of kidney problems, dehydration, or heart failure.

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Polyuria

Excessive urine production, usually more than 2.5 to 3 liters per day. Can be caused by diabetes mellitus, excessive water intake, or certain medications.

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Enuresis

Involuntary urination, particularly in children.

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Nocturnal Enuresis

Involuntary urination at night, especially in children.

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Bilirubin

A breakdown product of red blood cell destruction, a key indicator of liver disease or bile obstruction. It is produced from hemoglobin in the degradation process.

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Hematuria

The presence of red blood cells in urine, often a sign of UTI or renal dysfunction.

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Jaundice (Yellow-Orange Color)

Yellow-orange discoloration of urine, often indicates high levels of bilirubin.

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Red Blood Cells (RBCs)

Red blood cells, responsible for oxygen transport in the body. They are biconcave in shape, lack a nucleus, and contain iron for oxygen binding.

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White Blood Cells (WBCs)

White blood cells, crucial for the immune system. They are colorless, contain a nucleus, and fight off infections.

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Apoptosis

The process by which cells break down and die in a controlled manner, removing damaged cells and preventing harm to the body.

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Erythropoiesis

The process of producing new red blood cells in the bone marrow.

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Reticulocytes

Immature red blood cells that still contain some RNA, giving them a bluish tint when stained. They are released from the bone marrow to increase blood cell count during emergencies.

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Granular WBCs

A type of white blood cell that contains granules filled with digestive enzymes. These enzymes help destroy foreign cells, such as bacteria and viruses.

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Agranular WBCs

A type of white blood cell that lacks granules. They play a key role in adaptive immune responses, targeting specific invaders.

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Hemoglobin Breakdown

The process of breaking down old red blood cells in the liver and spleen. Bilirubin, a yellow pigment, is a byproduct of this process.

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Zygote Banking

A process of storing fertilized eggs (zygotes) in a specialized facility.

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Allograft

A type of tissue transplant where the donor and recipient are of the same species.

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Short-Term Cryobanking

Storage of sperm or zygotes for less than a year, often used for future insemination or fertility treatment.

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Long-Term Cryobanking

Storage of sperm or zygotes for longer than a year, providing a backup option for future reproductive plans.

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Sex Prediction

A technique that involves predicting the sex of an unborn baby.

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Sex Selection

A technique that aims to control the sex of a child before or during pregnancy.

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Cloning

The creation of an organism that is a genetically identical copy of another.

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Artificial Embryo Twinning

A method of cloning where a very early embryo is split into individual cells, allowing for multiple embryos to develop and be implanted.

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Opportunistic Pathogen

A microorganism that causes disease, often found in the body and can take advantage of weakened immune systems.

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Vector

A living organism that can carry and transmit a disease-causing agent (pathogen) to another organism without becoming ill itself.

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Reservoir Host

A person or animal that harbors a pathogen and can spread the infection to others.

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Portal of Exit

The means by which a pathogen leaves the body of an infected individual, such as bodily fluids, droplets, or secretions.

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Mode of Transmission

The transfer of pathogens from one individual to another. This can occur through direct contact, airborne transmission, or through vectors.

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Gloves

The most essential piece of Personal Protective Equipment (PPE) used in a medical laboratory.

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Mask

A type of Personal Protective Equipment (PPE) designed to protect the wearer from airborne droplets, usually used during procedures involving coughing or sneezing.

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Standard Precautions

Essential practices in a medical laboratory to ensure safety and prevent the spread of infections. These practices include proper hand hygiene, wearing appropriate PPE, and following specific guidelines for handling specimens.

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Microalbuminuria

Small amount of albumin in urine, often seen in diabetes, strenuous exercise, or dehydration.

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Ketonuria

Presence of ketones in urine, indicating abnormal fat metabolism. May be seen in Diabetes Mellitus, Malabsorption, low carbohydrate intake, or vomiting.

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Ketones

Ketones are produced when the body breaks down fat for energy. They are released into the bloodstream as three products: Acetone, Acetoacetic acid, and Beta-hydroxybutyric acid.

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Nitrite

Presence of bacteria in urine, detected by the nitrite test.

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Leukocytes in Urine

The presence of white blood cells in urine, usually indicating inflammation or infection of the urinary tract.

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Leukocyte Esterase

A substance present in granulocytic white blood cells, detected by reagent strips. It is another indicator of urinary tract infection.

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Urine pH

The measure of acidity or alkalinity in urine, typically normal range is 4.6 - 8.0.

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Proteinuria

Presence of protein in urine.

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Study Notes

Hematology Section

  • Hematology studies blood, blood-forming tissues, and blood disorders
  • Includes blood components like RBCs, WBCs, and platelets
  • Anemia and leukemia are related blood disorders

Hematopoiesis / Blood Cell Formation

  • Process of blood cell development
  • Primarily occurs in red bone marrow
  • All blood cells originate from stem cells

Blood Cell Types

  • Erythrocytes (RBCs): Most numerous, carry oxygen, contain hemoglobin
  • Leukocytes (WBCs): Include granular (neutrophils, eosinophils, basophils) and agranular (lymphocytes, monocytes) cells; crucial for the immune response
  • Platelets (Thrombocytes): Essential for blood clotting

Factors Stimulating Blood Cell Production

  • Intrinsic Factor: Aids in Vitamin B12 absorption
  • Thrombopoietin: Stimulates platelet production
  • Colony-Stimulating Factor (CSF): Increases leukocyte formation
  • Interleukins: Influence lymphocyte growth and activation
  • Erythropoietin (EPO): Stimulates RBC production in response to low oxygen levels

Stem Cells

  • Precursors of all blood cells
  • Have the capacity for self-renewal and differentiation
  • Self-renewal is the ability to divide and produce more stem cells with the same properties
  • Anemia affects red blood cells
  • Leukemia affects white blood cells
  • Disorders related to platelets include dengue and CFD

Other

  • Blast cells are immature blood cells at different stages of development leading to RBCs, WBCs and platelets.
  • Reticulocytes are immature red blood cells.
  • Leukocytes are responsible for the immune response.
  • Granular WBCs include neutrophils, eosinophils, and basophils.
  • Agranular WBCs include lymphocytes and monocytes.
  • Monocytes in the blood are called macrophages when in the tissues.
  • Reticulocytes have remnant RNA, which stains blue when using a special stain
  • RBCs (Erythrocytes) circulate for 120 days.
  • Types of blood cells in the circulating blood include RBCs, WBCs, and platelets.

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