Anticoagulants Quiz
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Questions and Answers

What is the most common nutritional deficiency leading to anemia?

  • Vitamin C deficiency
  • Folic acid deficiency
  • Iron deficiency (correct)
  • Vitamin B-12 deficiency

Which supplement is commonly advised for pregnant women with anemia?

  • Vitamin K
  • Vitamin B-12
  • Ferrous Sulfate (correct)
  • Vitamin D

What is the storage form of iron in intestinal mucosal cells?

  • Ferritin (correct)
  • Folate
  • Transferrin
  • Hemosiderin

Which condition results in microscopically hypochromic microcytic anemia?

<p>Iron Deficiency Anemia (A)</p> Signup and view all the answers

What glycoprotein is responsible for the absorption of vitamin B-12?

<p>Intrinsic Factor (B)</p> Signup and view all the answers

What is the most common cause of vitamin B-12 deficiency?

<p>Poor absorption (B)</p> Signup and view all the answers

Which condition is characterized by a negative Fe++ balance?

<p>Iron Deficiency Anemia (B)</p> Signup and view all the answers

What is the most common side effect of oral ferrous sulfate supplementation?

<p>Constipation (C)</p> Signup and view all the answers

What is the primary cause of cyanocobalamin (Vitamin B-12) deficiency in pernicious anemia?

<p>Poor absorption (B)</p> Signup and view all the answers

Which nutrient deficiency can result in anemia during pregnancy and lactation?

<p>Folic Acid (D)</p> Signup and view all the answers

Which thrombin antagonist has little or no activity on platelet function?

<p>Lepirudin (C)</p> Signup and view all the answers

Which thrombolytic agent has a window period of 2-6 hours for myocardial salvage in Acute Cerebral Ischemia (CVA)?

<p>Alteplase (tPA)-ACTIVASE (B)</p> Signup and view all the answers

Which thrombolytic agent is obtained from recombinant DNA and couples specifically with fibrin in a thrombus?

<p>Alteplase (tPA)-ACTIVASE (D)</p> Signup and view all the answers

Which drug is a synthetic agent that inhibits plasminogen activation and may lead to complications such as intravascular thrombus?

<p>Aminocaproic Acid (B)</p> Signup and view all the answers

Which drug is used to antagonize the anticoagulant effect of heparin and may lead to side effects like hypersensitivity, dyspnea, bradycardia, and hypotension when given IV rapidly?

<p>Protamine Sulfate (D)</p> Signup and view all the answers

Which drug is used to stop bleeding secondary to oral anticoagulants and has a slow response time of over 24 hours?

<p>Vitamin K (B)</p> Signup and view all the answers

Which thrombolytic agent has the highest antigenicity and catalyzes degradation of fibrinogen and state factors V and VII?

<p>Streptokinase (D)</p> Signup and view all the answers

Which thrombolytic agent is a modified streptokinase molecule semi-selective for clot site and has a half-life of 90 minutes?

<p>Tenecteplase- TNKASE (C)</p> Signup and view all the answers

Which drug is used as an antidote for Warfarin-induced bleeding?

<p>Vitamin K1 (C)</p> Signup and view all the answers

Which thrombin antagonist is used prophylactically in heparin-induced thrombocytopenia (HIT)?

<p>Argatroban (A)</p> Signup and view all the answers

What is the role of intrinsic factor in the body?

<p>It is crucial for the absorption of vitamin B12 by the terminal ileum (B)</p> Signup and view all the answers

What is the function of erythropoietin?

<p>It stimulates red blood cell production (B)</p> Signup and view all the answers

In which conditions is hydroxyurea used?

<p>Chronic myelogenous leukemia (C)</p> Signup and view all the answers

What is the primary function of heparin?

<p>It is a rapid-acting anticoagulant that inhibits several clotting factors (C)</p> Signup and view all the answers

What is the role of warfarin in the body?

<p>It antagonizes vitamin K function (D)</p> Signup and view all the answers

What is the difference between a thrombus and an emboli?

<p>A thrombus is a pathologic clot in a blood vessel, while emboli are floating thrombi (B)</p> Signup and view all the answers

What is the mechanism of action of platelet aggregators like collagen and ADP?

<p>They play a role in platelet activation process (A)</p> Signup and view all the answers

What adverse effects are associated with heparin?

<p>Hemorrhage and hypersensitivity (B)</p> Signup and view all the answers

What is the primary adverse effect of warfarin?

<p>Hemorrhage and minor bleeding (D)</p> Signup and view all the answers

What is the function of thrombus in the body?

<p>It is a pathologic clot in a blood vessel (D)</p> Signup and view all the answers

Flashcards

What is the most common nutritional deficiency leading to anemia?

Iron deficiency is the most common cause of anemia, a condition where the red blood cell count is low.

Which supplement is commonly advised for pregnant women with anemia?

Ferrous sulfate is a commonly prescribed iron supplement for pregnant women with anemia, helping replenish iron levels.

What is the storage form of iron in intestinal mucosal cells?

Ferritin acts as a storage form of iron within intestinal mucosal cells, ensuring its availability as needed.

Which condition results in microscopically hypochromic microcytic anemia?

Iron deficiency anemia (IDA) is characterized by small, pale red blood cells (microcytic) due to insufficient iron for hemoglobin production.

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What glycoprotein is responsible for the absorption of vitamin B-12?

Intrinsic factor is a glycoprotein essential for the absorption of vitamin B-12 in the terminal ileum.

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What is the most common cause of vitamin B-12 deficiency?

Poor absorption of vitamin B-12, often due to conditions like pernicious anemia, is the most common cause of deficiency.

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Which condition is characterized by a negative Fe++ balance?

Iron deficiency anemia (IDA) occurs when the body has a negative iron balance, leading to insufficient iron for red blood cell production.

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What is the most common side effect of oral ferrous sulfate supplementation?

Constipation is a frequent side effect of oral ferrous sulfate supplementation, due to its effect on the digestive system.

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What is the primary cause of cyanocobalamin (Vitamin B-12) deficiency in pernicious anemia?

Pernicious anemia primarily results from poor absorption of cyanocobalamin (vitamin B-12) due to a lack of intrinsic factor.

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Which nutrient deficiency can result in anemia during pregnancy and lactation?

Folic acid deficiency can lead to anemia during pregnancy and lactation, as these periods require increased folate levels for cell division.

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Which thrombin antagonist has little or no activity on platelet function?

Lepirudin is a thrombin antagonist that primarily targets thrombin, having minimal effect on platelet function.

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Which thrombolytic agent has a window period of 2-6 hours for myocardial salvage in Acute Cerebral Ischemia (CVA)?

Alteplase (tPA)-ACTIVASE is a thrombolytic agent used within a narrow window of 2-6 hours after a stroke to dissolve clots and potentially save brain tissue.

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Which thrombolytic agent is obtained from recombinant DNA and couples specifically with fibrin in a thrombus?

Alteplase (tPA)-ACTIVASE is a recombinant thrombolytic agent that specifically binds to fibrin in a thrombus, promoting its breakdown.

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Which drug is a synthetic agent that inhibits plasminogen activation and may lead to complications such as intravascular thrombus?

Aminocaproic acid is a synthetic agent that inhibits plasminogen activation, potentially leading to complications like blood clots due to its anti-fibrinolytic effect.

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Which drug is used to antagonize the anticoagulant effect of heparin and may lead to side effects like hypersensitivity, dyspnea, bradycardia, and hypotension when given IV rapidly?

Protamine sulfate is used to counteract the anticoagulant effects of heparin, but rapid IV administration can cause adverse reactions like hypersensitivity, breathing difficulties, and low heart rate and blood pressure.

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Which drug is used to stop bleeding secondary to oral anticoagulants and has a slow response time of over 24 hours?

Vitamin K is administered to stop bleeding caused by oral anticoagulants but takes a long time - over 24 hours - to be effective.

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Which thrombolytic agent has the highest antigenicity and catalyzes degradation of fibrinogen and state factors V and VII?

Streptokinase has the highest antigenicity among thrombolytic agents, breaking down fibrinogen, factor V, and factor VII. It's a naturally occurring enzyme produced by some bacteria.

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Which thrombolytic agent is a modified streptokinase molecule semi-selective for clot site and has a half-life of 90 minutes?

Tenecteplase- TNKASE, a modified form of Streptokinase, exhibits semi-selectivity for the clot site, making it more targeted than its parent molecule.

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Which drug is used as an antidote for Warfarin-induced bleeding?

Vitamin K1 is used as an antidote for bleeding caused by Warfarin, an oral anticoagulant.

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Which thrombin antagonist is used prophylactically in heparin-induced thrombocytopenia (HIT)?

Argatroban is a thrombin antagonist used prophylactically to prevent blood clots in patients with heparin-induced thrombocytopenia (HIT).

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What is the role of intrinsic factor in the body?

Intrinsic factor plays a crucial role in the absorption of vitamin B12 in the terminal ileum, ensuring its availability for vital functions.

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What is the function of erythropoietin?

Erythropoietin, a hormone primarily produced by the kidneys, stimulates the production of red blood cells in the bone marrow.

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In which conditions is hydroxyurea used?

Hydroxyurea is used in the treatment of chronic myelogenous leukemia (CML) and sickle cell anemia, helping to reduce the number of abnormal blood cells.

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What is the primary function of heparin?

Heparin, a naturally occurring anticoagulant, inhibits several clotting factors in the coagulation cascade, rapidly preventing blood clotting.

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What is the role of warfarin in the body?

Warfarin, an oral anticoagulant, works by antagonizing vitamin K, interfering with the production of clotting factors in the liver.

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What is the difference between a thrombus and an emboli?

A thrombus is a blood clot that forms within a blood vessel, while an emboli is a thrombus that detaches and travels through the bloodstream.

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What is the mechanism of action of platelet aggregators like collagen and ADP?

Platelet aggregators like collagen and ADP activate platelets, triggering their clumping together to form a platelet plug, a crucial part of hemostasis.

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What adverse effects are associated with heparin?

Common adverse effects of heparin include hemorrhage due to its anticoagulant action, and hypersensitivity reactions.

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What is the primary adverse effect of warfarin?

Hemorrhage and minor bleeding are the primary adverse effects of warfarin, due to its anticoagulant properties.

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What is the function of thrombus in the body?

A thrombus is a pathologic clot in a blood vessel, a key feature in several cardiovascular diseases.

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Study Notes

Hematologic Medications and Processes Summary

  • Intrinsic factor is crucial for the absorption of vitamin B12 by the terminal ileum.
  • Erythropoietin is a hormone that stimulates red blood cell production and is used in conditions like end-stage renal disease and HIV.
  • Hydroxyurea is a cancer drug used in chronic myelogenous leukemia, polycythemia vera, and sickle cell anemia to increase fetal hemoglobin concentration.
  • Hemostasis maintains clot formation balance in healthy tissue, involving platelets and proteins.
  • Thrombus is a pathologic clot in a blood vessel, while emboli are floating thrombi.
  • Clot formation depends on platelet number and coagulation cascade activation, involving adhesion, degranulation, and aggregation.
  • Platelet aggregators like collagen and ADP play a role in the activation process.
  • Platelet aggregator inhibitors like aspirin, dipyridamole, ticlopidine, clopidogrel, abciximab, eptifibatide, and tirofiban are used in cardiovascular disease prevention and treatment.
  • Heparin is a rapid-acting anticoagulant that inhibits several clotting factors and is used in DVT, PE, and extracorporeal devices.
  • Warfarin, an anticoagulant, antagonizes vitamin K function and is used in conditions like atrial fibrillation and venous thrombosis.
  • Heparin is metabolized in the liver, excreted by the kidney, and has adverse effects like hemorrhage and hypersensitivity.
  • Warfarin is 99% bound to albumin, crosses the placenta, and has adverse effects like hemorrhage and minor bleeding.

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Description

Test your knowledge of hematologic medications and processes with this informative quiz. Explore topics like erythropoietin, hydroxyurea, hemostasis, thrombus, emboli, platelet aggregation, anticoagulants like heparin and warfarin, and more. Perfect for students, healthcare professionals, or anyone interested in hematology.

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