30 Questions
What is the most common nutritional deficiency leading to anemia?
Iron deficiency
Which supplement is commonly advised for pregnant women with anemia?
Ferrous Sulfate
What is the storage form of iron in intestinal mucosal cells?
Ferritin
Which condition results in microscopically hypochromic microcytic anemia?
Iron Deficiency Anemia
What glycoprotein is responsible for the absorption of vitamin B-12?
Intrinsic Factor
What is the most common cause of vitamin B-12 deficiency?
Poor absorption
Which condition is characterized by a negative Fe++ balance?
Iron Deficiency Anemia
What is the most common side effect of oral ferrous sulfate supplementation?
Constipation
What is the primary cause of cyanocobalamin (Vitamin B-12) deficiency in pernicious anemia?
Poor absorption
Which nutrient deficiency can result in anemia during pregnancy and lactation?
Folic Acid
Which thrombin antagonist has little or no activity on platelet function?
Lepirudin
Which thrombolytic agent has a window period of 2-6 hours for myocardial salvage in Acute Cerebral Ischemia (CVA)?
Alteplase (tPA)-ACTIVASE
Which thrombolytic agent is obtained from recombinant DNA and couples specifically with fibrin in a thrombus?
Alteplase (tPA)-ACTIVASE
Which drug is a synthetic agent that inhibits plasminogen activation and may lead to complications such as intravascular thrombus?
Aminocaproic Acid
Which drug is used to antagonize the anticoagulant effect of heparin and may lead to side effects like hypersensitivity, dyspnea, bradycardia, and hypotension when given IV rapidly?
Protamine Sulfate
Which drug is used to stop bleeding secondary to oral anticoagulants and has a slow response time of over 24 hours?
Vitamin K
Which thrombolytic agent has the highest antigenicity and catalyzes degradation of fibrinogen and state factors V and VII?
Streptokinase
Which thrombolytic agent is a modified streptokinase molecule semi-selective for clot site and has a half-life of 90 minutes?
Tenecteplase- TNKASE
Which drug is used as an antidote for Warfarin-induced bleeding?
Vitamin K1
Which thrombin antagonist is used prophylactically in heparin-induced thrombocytopenia (HIT)?
Argatroban
What is the role of intrinsic factor in the body?
It is crucial for the absorption of vitamin B12 by the terminal ileum
What is the function of erythropoietin?
It stimulates red blood cell production
In which conditions is hydroxyurea used?
Chronic myelogenous leukemia
What is the primary function of heparin?
It is a rapid-acting anticoagulant that inhibits several clotting factors
What is the role of warfarin in the body?
It antagonizes vitamin K function
What is the difference between a thrombus and an emboli?
A thrombus is a pathologic clot in a blood vessel, while emboli are floating thrombi
What is the mechanism of action of platelet aggregators like collagen and ADP?
They play a role in platelet activation process
What adverse effects are associated with heparin?
Hemorrhage and hypersensitivity
What is the primary adverse effect of warfarin?
Hemorrhage and minor bleeding
What is the function of thrombus in the body?
It is a pathologic clot in a blood vessel
Study Notes
Hematologic Medications and Processes Summary
- Intrinsic factor is crucial for the absorption of vitamin B12 by the terminal ileum.
- Erythropoietin is a hormone that stimulates red blood cell production and is used in conditions like end-stage renal disease and HIV.
- Hydroxyurea is a cancer drug used in chronic myelogenous leukemia, polycythemia vera, and sickle cell anemia to increase fetal hemoglobin concentration.
- Hemostasis maintains clot formation balance in healthy tissue, involving platelets and proteins.
- Thrombus is a pathologic clot in a blood vessel, while emboli are floating thrombi.
- Clot formation depends on platelet number and coagulation cascade activation, involving adhesion, degranulation, and aggregation.
- Platelet aggregators like collagen and ADP play a role in the activation process.
- Platelet aggregator inhibitors like aspirin, dipyridamole, ticlopidine, clopidogrel, abciximab, eptifibatide, and tirofiban are used in cardiovascular disease prevention and treatment.
- Heparin is a rapid-acting anticoagulant that inhibits several clotting factors and is used in DVT, PE, and extracorporeal devices.
- Warfarin, an anticoagulant, antagonizes vitamin K function and is used in conditions like atrial fibrillation and venous thrombosis.
- Heparin is metabolized in the liver, excreted by the kidney, and has adverse effects like hemorrhage and hypersensitivity.
- Warfarin is 99% bound to albumin, crosses the placenta, and has adverse effects like hemorrhage and minor bleeding.
Test your knowledge of hematologic medications and processes with this informative quiz. Explore topics like erythropoietin, hydroxyurea, hemostasis, thrombus, emboli, platelet aggregation, anticoagulants like heparin and warfarin, and more. Perfect for students, healthcare professionals, or anyone interested in hematology.
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