Hematology: Anemia and Blood Tests
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Questions and Answers

What is the typical reticulocyte count in healthy individuals?

  • 0.5-1%
  • 1-2% (correct)
  • 3-4%
  • 2-3%

Macrocytic anemia is associated with decreased production of red blood corpuscles.

False (B)

Name one condition that can lead to increased destruction of red blood corpuscles.

Hemolytic anemia

Anemia due to iron deficiency results in ________ RBC morphology.

<p>Microcytic</p> Signup and view all the answers

Match the following types of anemia with their associated causes:

<p>Aplastic anemia = Decreased production Pernicious anemia = Decreased maturation Sickle cell anemia = Increased destruction Iron deficiency anemia = Decreased maturation</p> Signup and view all the answers

What change in reticulocyte count is expected in hemolytic anemia?

<p>Increased (A)</p> Signup and view all the answers

Sickle-shaped RBCs are an indicator of increased destruction in sickle cell anemia.

<p>True (A)</p> Signup and view all the answers

Identify one type of anemia caused by decreased maturation of RBCs.

<p>Folic acid deficiency anemia</p> Signup and view all the answers

Which of the following is NOT part of a standard haemogram (CBC)?

<p>Blood glucose level (A)</p> Signup and view all the answers

The Erythrocyte Sedimentation Rate (ESR) is used to evaluate blood chemistry.

<p>False (B)</p> Signup and view all the answers

Name one test included in the tests for diabetes mellitus.

<p>Blood Glucose Level</p> Signup and view all the answers

Testing for ____ function is part of the tests for haemostasis.

<p>Platelet</p> Signup and view all the answers

Match the laboratory investigation type with its corresponding test:

<p>Haemogram (CBC) = Red blood cell count Tests for Haemostasis = Platelet count Tests for Diabetes Mellitus = Glycosylated Hemoglobin (HbA1C) Blood Chemistry = Electrolyte levels</p> Signup and view all the answers

Which investigation would you use to assess the clotting factors?

<p>Tests for Haemostasis (C)</p> Signup and view all the answers

Self assessment tests are used to monitor blood glucose levels.

<p>True (A)</p> Signup and view all the answers

What test might be performed to determine if someone has ketoacidosis?

<p>Blood chemistry analysis</p> Signup and view all the answers

Which test is specifically used to assess glucose levels over a period of time in diabetes management?

<p>Glycosylated Hemoglobin (HbA1C) (D)</p> Signup and view all the answers

Blood diseases do not impact dental treatments.

<p>False (B)</p> Signup and view all the answers

What are the main types of tests included in a complete blood count?

<p>Red blood cell count, Hemoglobin concentration, Total white blood cell count, Differential white blood cell count, Platelet count, Erythrocyte Sedimentation Rate (ESR)</p> Signup and view all the answers

The test used to evaluate kidney function is known as __________.

<p>Glucose tolerance test</p> Signup and view all the answers

Match the following tests with their purposes:

<p>Glycosylated Hemoglobin = Diabetes management Erythrocyte Sedimentation Rate (ESR) = Inflammation assessment Complete Blood Count = General health check Ketoacidosis testing = Acid-base imbalance evaluation</p> Signup and view all the answers

Which of the following conditions would NOT typically show oral manifestations?

<p>Hyperlipidemia (A)</p> Signup and view all the answers

The differential white blood cell count is part of the haemogram.

<p>True (A)</p> Signup and view all the answers

List one reason why blood tests are important for dentists.

<p>Some blood diseases show oral manifestations.</p> Signup and view all the answers

What is the average normal mean corpuscular hemoglobin concentration (MCHC)?

<p>34% (B)</p> Signup and view all the answers

Eosinophils are primarily involved in the defense against bacterial infections.

<p>False (B)</p> Signup and view all the answers

What hemoglobin concentration indicates hypochromic anemia?

<p>Less than 30%</p> Signup and view all the answers

Both B-cells and T-cells are types of ______ which play a role in immune response.

<p>lymphocytes</p> Signup and view all the answers

Match the following blood cell components with their primary function:

<p>Neutrophils = Defense against bacterial infections Eosinophils = Defense against parasitic infections Basophils = Role in allergic reactions Monocytes = Phagocytosis and antigen presentation</p> Signup and view all the answers

Which condition is likely associated with leukocytosis?

<p>Infections (D)</p> Signup and view all the answers

Children have a lower normal white blood cell count than adults.

<p>False (B)</p> Signup and view all the answers

What are the normal white blood cell count ranges for adults?

<p>4,000-11,000/mm3</p> Signup and view all the answers

What is considered normal glucose tolerance for 2 hours post-prandial glucose (2h PPG)?

<p>2h PPG &lt; 140 mg/dl (D)</p> Signup and view all the answers

A 2h PPG value greater than 200 mg/dl indicates a provisional diagnosis of diabetes mellitus.

<p>True (A)</p> Signup and view all the answers

What is the fasting blood glucose level considered normal?

<p>approximately 100 mg/dl</p> Signup and view all the answers

For the glucose tolerance test, a measured dose of glucose can be administrated either orally as _____ grams or intravenously as 0.5 mg glucose per kg body weight.

<p>75</p> Signup and view all the answers

Match the glucose levels with their time post-glucose administration for a glucose tolerance test:

<p>Fasting = approximately 100 mg/dl ½ hour = 120-160 mg/dl 1 hour = 160 mg/dl 2 hours = greater than 200 mg/dl</p> Signup and view all the answers

Which of the following is NOT an advantage of the glucose tolerance test?

<p>Cheap and quick (D)</p> Signup and view all the answers

Blood samples for a glucose tolerance test are typically taken at ½ hour, 1 hour, 2 hours, and 3 hours after glucose administration.

<p>True (A)</p> Signup and view all the answers

Name one disadvantage of the glucose tolerance test.

<p>Time-consuming or expensive or exhausting for the patient</p> Signup and view all the answers

Which type of tests are performed for Diabetes Mellitus?

<p>Total Glucose Tolerance Test (C)</p> Signup and view all the answers

The Erythrocyte Sedimentation Rate (ESR) is a test for kidney function.

<p>False (B)</p> Signup and view all the answers

What does HbA1C stand for?

<p>Glycosylated Hemoglobin</p> Signup and view all the answers

The total _____ count is measured in WBC/mm3.

<p>white blood cell</p> Signup and view all the answers

Which test is least likely to be associated with evaluating liver function?

<p>Ketoacidosis testing (A)</p> Signup and view all the answers

Self-assessment tests are designed for blood sampling.

<p>False (B)</p> Signup and view all the answers

What does CBC stand for in the context of testing?

<p>Complete Blood Count</p> Signup and view all the answers

Flashcards

Red blood cell count (RBC/mm3)

A blood test that measures the number of red blood cells per cubic millimeter.

Hemoglobin level (Hb %)

A blood test that measures the amount of hemoglobin in the blood.

White blood cell count (WBC/mm3)

A blood test that measures the number of white blood cells per cubic millimeter.

Differential white blood cell count

A blood test that measures the percentage of different types of white blood cells in the blood.

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Platelet count

A blood test that measures the number of platelets in the blood.

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Erythrocyte Sedimentation Rate (ESR)

A blood test that measures the rate at which red blood cells settle in a tube.

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Glycosylated Hemoglobin (HbA1C)

A measure of how much glucose is attached to hemoglobin in the blood.

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Blood Glucose concentration

A blood test that measures the amount of sugar in the blood.

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Complete Blood Count (CBC)

A blood test that measures the number of red blood cells, white blood cells, and platelets in a sample of blood.

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Tests for Hemostasis

A group of tests that assess the body's ability to stop bleeding.

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Tests for Diabetes Mellitus

A group of tests that help diagnose and monitor diabetes mellitus.

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Blood Chemistry

A comprehensive analysis of various chemical components in the blood, including electrolytes, enzymes, and proteins.

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Biopsy

A procedure where a small sample of tissue is removed for microscopic examination.

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Red Blood Cell Count (RBC)

A test that measures the number of red blood cells in a sample of blood.

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Hemoglobin Concentration (Hb%)

A test that measures the amount of hemoglobin in the blood.

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Total White Blood Cell Count (WBC)

A test that measures the number of white blood cells in a sample of blood.

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Haemogram (Complete Blood Count)

A blood test that measures various components of the blood, including red blood cells, white blood cells, and platelets.

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Main function of Red Blood Cells (RBCs)

The main function of red blood cells is to carry oxygen from the lungs to the rest of the body.

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White Blood Cell Count

A blood test that determines the number of white blood cells in the blood, aiding in identifying infection or inflammation.

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Testing the Clotting Factors

A blood test that measures the clotting ability of blood, crucial for assessing bleeding disorders.

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Mean Corpuscular Hemoglobin Concentration (MCHC)

The average amount of hemoglobin contained in a red blood cell, important for understanding oxygen-carrying capacity.

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Normal Red Blood Cell Counts (RBCs)

The range of red blood cells considered normal for males, females, and children (< 1 year and > 1 year).

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Anemia

A condition where the hemoglobin concentration in the blood is below normal levels, indicating insufficient oxygen-carrying capacity.

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Polycythemia

A condition where the hemoglobin concentration in the blood is above normal levels, indicating an excess of red blood cells.

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Neutrophils

The first line of defense against bacterial and fungal infections, playing a crucial role in immune response.

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Eosinophils

Important in fighting parasitic infections and allergic reactions.

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Basophils

Involved in allergic reactions.

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Lymphocytes

Important immune cells responsible for producing antibodies (B-cells) and directly attacking infected cells (T-cells).

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2-hour Postprandial Glucose (2h PPG)

A blood test that measures blood sugar levels two hours after a meal, helping to diagnose diabetes and identify individuals with impaired glucose tolerance.

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Post-Challenge Plasma Glucose (PCG)

A blood test that measures blood sugar levels two hours after consuming a sugary drink, used for diagnosing diabetes.

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Postprandial Glucose (PPG)

A blood test that measures blood sugar levels two hours after a regular breakfast, helping to monitor diabetes and identify pre-diabetic individuals.

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Glucose Tolerance Test (GTT)

A test that measures the body's response to a specific amount of glucose given orally or intravenously. It helps diagnose diabetes and assess glucose tolerance.

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Impaired Glucose Tolerance (IGT)

A blood sugar level between 140 and 200 mg/dl, two hours after a meal or glucose load, indicating impaired glucose tolerance, a pre-diabetic condition.

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Normal Glucose Tolerance

A blood sugar level below 140 mg/dl, two hours after a meal or glucose load, indicating normal glucose tolerance.

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Provisional Diagnosis of Diabetes

A blood sugar level above 200 mg/dl, two hours after a meal or glucose load, indicating a provisional diagnosis of diabetes.

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Oral Glucose Tolerance Test (OGTT)

An oral glucose tolerance test (OGTT) involves consuming 75 grams of glucose dissolved in water.

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Decreased Production of RBCs

A decrease in the production of red blood cells (RBCs) by the bone marrow. This can be caused by underlying conditions like aplastic anemia, bone marrow disease, or kidney issues.

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Decreased Maturation of RBCs

Anemia due to faulty maturation of red blood cells. This can be caused by deficiencies in essential nutrients like Vitamin B12 (pernicious anemia), folic acid, or iron.

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Increased Destruction of RBCs

Anemia due to increased destruction of red blood cells. This can occur in cases of hemolytic anemias, where RBCs break down prematurely, or due to excessive blood loss.

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Microcytic Anemia

A type of anemia where the red blood cells are smaller than normal, often caused by iron deficiency.

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Macrocytic Anemia

A type of anemia where the red blood cells are larger than normal, often caused by vitamin B12 or folate deficiency.

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Reticulocyte Count

A measure of the number of young red blood cells in the bloodstream. It indicates the bone marrow's ability to produce new RBCs.

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Decreased Reticulocyte Count

Anemia characterized by a decreased number of reticulocytes, indicating a problem with bone marrow production.

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Study Notes

Laboratory Investigations

  • Presented by Dr. Maha Abdelkawy Fahmy, Oral Medicine and Periodontology Department, Faculty of Dentistry, Beni-Suef University
  • Includes various laboratory investigations, including complete blood count (CBC), tests for hemostasis, diabetes mellitus, blood chemistry, and biopsy

1- Haemogram (CBC) (Complete Blood Count)

  • Includes:
    • Red blood cell count (RBC/mm3)
    • Hemoglobin concentration (Hb %)
    • Total white blood cell count (WBC/mm3)
    • Differential white blood cell count
    • Platelet count
    • Erythrocyte Sedimentation Rate (ESR)

2- Tests for Haemostasis

  • Testing Capillary Function (Hess test)
  • Testing Platelet Function (PFA-100)
  • Testing Clotting Factors (various tests)

3- Tests for Diabetes Mellitus

  • Test Paper Strips
  • Blood Glucose Level (casual/random, fasting)
  • Oral Glucose Tolerance Test (OGTT)
  • Urinary Glucose
  • Glycosylated Hemoglobin (HbA1c)
  • Ketoacidosis
  • Self Assessment tests

4- Blood Chemistry

  • Tests to check Liver function (Alkaline Phosphatase, Serum transaminases, Serum bilirubin, Blood glucose level, Blood urea nitrogen)
  • Tests to check Kidney function (Blood urea nitrogen, Creatinine level, Creatinine clearance, Uric acid)
  • Tests for patients with multiple jaw bone lesions (Alkaline phosphatase enzyme, Serum Ca, Serum P)

5- Biopsy

  • Microscopic examination of tissues from the living body to reach a definite diagnosis.

  • Indications:

    • When careful examination fails to reach the diagnosis
    • To recognize precancerous lesions
    • Lesions which present clinical signs of malignancy
    • Lesions that failed to respond to therapy
    • To differentiate between lesions
    • When there is doubt
  • Principles of Biopsy surgery:

    • Anesthesia: Nerve block preferred over infiltration
    • Tissue Stabilization: Specialised retractors, traction sutures, digital stabilization. Avoid crushing.
    • Hemostasis: Gauze compresses adequate, Avoid Suction devices.
    • Incisions: Multiple scalpels, sufficient tissue, include clinically normal tissue for comparison.
    • Handling Specimen Care: Place in large mouthed bottle, use 10% formalin, for thin specimens place on glazed paper.
  • Types of Biopsy:

    • Excisional
    • Incisional
    • Aspiration
    • Punch
    • Drill
    • Exfoliative Cytology
    • Brush

Additional Topics

  • Erythrocytes (Red Blood Cells):

    • Functioning: Carrying oxygen
    • Maturation: Reticulocytes (1-2% of RBC count), unnucleated, no RNA
    • Life Span: 120 days, destroyed in liver and spleen
    • Morphology: Biconcave discs, 2 microns thick
  • Hemoglobin concentration: Normal range and conditions causing deviations

  • Leukocytes (White Blood Cells):

    • Types: Neutrophils, Basophils, Eosinophils, Lymphocytes, Monocytes
    • Functions of different cell types
    • Normal range and disorders
  • Platelet count: Normal range and conditions causing deviations

  • Erythrocyte sedimentation rate (ESR): Indicates an active disease process

  • Hepatitis B virus (HBV): Markers and interpretation

  • Hepatitis C virus (HCV): Diagnosis based on anti-HCV IgG and PCR

  • Importance of liver function tests in dentistry: Link between liver function and clotting factors, infectivity risks, and drug metabolism

  • Kidney function tests (BUN, Uric acid, Serum Creatinine): Normal ranges and associated clinical conditions (Renal failure, Gout, Cancer)

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Laboratory Investigations PDF

Description

This quiz covers essential concepts in hematology, particularly focusing on various types of anemia, reticulocyte counts, and laboratory investigations. Test your knowledge on the causes, characteristics, and diagnostic tests associated with blood disorders and functions. Ideal for students studying medical or biological sciences.

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