Hematology and Blood Disorders Quiz
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Questions and Answers

What is a possible consequence of using corticosteroids?

  • Neutrophilia
  • Eosinophilia
  • Thrombocytopenia
  • Neutropenia (correct)

What is a characteristic of myelodysplastic syndrome?

  • Leukocytosis and thrombocytosis
  • Splenomegaly and lymphadenopathy
  • Leukopenia and thrombocytopenia (correct)
  • Hemolysis and cholelithiasis

Which condition is associated with acquired neutropenia?

  • Sjogren's syndrome (correct)
  • Rheumatoid arthritis
  • Chronic kidney disease
  • Hypertension

What is a characteristic of acute leukemias?

<p>Maturation arrest of hematopoietic stem cells (B)</p> Signup and view all the answers

What is the characteristic of chronic myeloid leukemia?

<p>Philadelphia chromosome (A)</p> Signup and view all the answers

What is the definition of agranulocytosis?

<p>Neutrophil count less than 1 × 109/L (A)</p> Signup and view all the answers

What is the indication for therapeutic splenectomy?

<p>Chronic immune thrombocytopenic purpura (ITP) (D)</p> Signup and view all the answers

What is the indication for therapeutic plasmapheresis?

<p>Thrombotic thrombocytopenic purpura (D)</p> Signup and view all the answers

What is the most common tumor of the pituitary gland?

<p>Adenoma (B)</p> Signup and view all the answers

In medullary thyroid cancer, which of the following levels is elevated?

<p>Calcitonin (B)</p> Signup and view all the answers

What are the clinical signs of myxedema coma?

<p>Decreased mental function, hypoventilation, hypothermia, bradycardia (B)</p> Signup and view all the answers

What is a characteristic ECG finding in hypothyroidism?

<p>Low voltage, sinus bradycardia (B)</p> Signup and view all the answers

What are the clinical manifestations of hypocorticism?

<p>Hypotension, shock, hypoglycemia, vomiting, fatigue (C)</p> Signup and view all the answers

What is a characteristic of primary hyperaldosteronism?

<p>Suppressed renin, elevated aldosterone, diastolic hypertension, hypokalemia (A)</p> Signup and view all the answers

What are the two most important side effects of thyrosuppressant therapy?

<p>Toxic hepatitis and agranulocytosis (B)</p> Signup and view all the answers

What is the basis of Zollinger-Ellison syndrome?

<p>Hyperproduction of gastrin (B)</p> Signup and view all the answers

Flashcards

Neutropenia

A decrease in the number of neutrophils in the blood, often caused by medications like corticosteroids.

Myelodysplastic Syndrome

A group of disorders characterized by ineffective blood cell production, leading to low red blood cells, white blood cells, and platelets.

Sjogren's Syndrome

Acquired neutropenia is a decrease in neutrophils caused by factors other than inherited conditions or medications. Sjogren's syndrome is an example.

Acute Leukemias

These are cancers affecting the development of white blood cells, specifically halting their maturation, resulting in a shortage of healthy blood cells.

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Chronic Myeloid Leukemia (CML)

This leukemia type is characterized by the Philadelphia chromosome, a genetic abnormality that leads to uncontrolled growth of white blood cells.

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Agranulocytosis

A condition where the neutrophil count drops below 1 × 109/L, putting individuals at risk for severe infections because of a compromised immune system.

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Therapeutic Splenectomy

A surgical procedure to remove the spleen, often performed to treat chronic immune thrombocytopenic purpura (ITP).

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Therapeutic Plasmapheresis

A procedure where blood is drawn from the body, the plasma is removed, and the remaining blood cells are returned to the body. It is used to treat conditions like thrombotic thrombocytopenic purpura.

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Pituitary Adenoma

The most common type of pituitary tumor, usually non-cancerous, that can cause hormonal imbalances depending on which hormones are affected.

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Medullary Thyroid Cancer

A type of thyroid cancer that produces high levels of calcitonin, a hormone that helps regulate calcium levels in the blood.

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Myxedema Coma

This condition is characterized by a lack of thyroid hormone, often leading to fatigue, weight gain, and slowed metabolism. Severe hypothyroidism can cause a coma with decreased mental function, hypoventilation, hypothermia, and bradycardia.

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Hypothyroidism ECG Findings

In hypothyroidism, the heart rate slows down due to the lack of thyroid hormone, leading to a low-voltage ECG with sinus bradycardia.

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Hypocorticism

Hypocorticism, also known as Addison's disease, is a condition where the adrenal glands don't produce enough cortisol. This can lead to a wide range of symptoms like fatigue, weight loss, low blood pressure, and difficulty dealing with stress.

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Primary Hyperaldosteronism

This condition is characterized by high aldosterone levels, which can cause low potassium levels, high blood pressure, and other health problems.

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Thyrosuppressant Therapy Side Effects

Thyroid suppressant medications can cause side effects including toxic hepatitis and agranulocytosis.

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Zollinger-Ellison Syndrome

A condition where a tumor in the pancreas produces high levels of gastrin, a hormone that stimulates stomach acid production. This can lead to ulcers, diarrhea, and other digestive problems.

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Study Notes

Blood Disorders

  • Neutropenia can occur as a consequence of using corticosteroids
  • In myelodysplastic syndrome, there is leukopenia and thrombocytopenia
  • Acquired neutropenia can be registered in patients with Sjogren's syndrome
  • Philadelphia chromosome-negative chronic myeloproliferative neoplasms include polycythemia vera, primary myelofibrosis, and others
  • Acute leukemias are characterized by interruption in maturation (maturation arrest)
  • The characteristic of chronic myeloid leukemia is the presence of Philadelphia chromosome
  • Agranulocytosis is a condition characterized by a neutrophil count lower than 0.5 × 10^9/L

Treatment and Diagnosis

  • Therapeutic splenectomy is used in the treatment of patients with chronic immune thrombocytopenic purpura (ITP)
  • Therapeutic plasmapheresis is applied during treatment of thrombotic thrombocytopenic purpura

Endocrine System

  • Clinical manifestations of acromegaly include enlargement of acral body parts (nose, ears, feet, hands)
  • The most common tumor of the pituitary gland is adenoma
  • In medullary thyroid cancer, calcitonin is elevated
  • Clinical signs of myxedema coma include decreased mental function, hypoventilation, hypothermia, and bradycardia
  • A characteristic ECG finding in hypothyroidism is low voltage and sinus bradycardia

Adrenal Glands

  • Clinical manifestations of hypocorticism include hypotension, shock, hypoglycemia, vomiting, and fatigue
  • Primary hyperaldosteronism is characterized by suppressed renin, elevated aldosterone, diastolic hypertension, and hypokalemia

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Description

This quiz covers various topics related to blood disorders, including neutropenia, myelodysplastic syndrome, and anemia. Test your knowledge and understanding of these complex medical concepts.

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