Week 2 - Hematologic Neoplasms Quiz

Which of the following is the most common site for lymph node enlargement in Hodgkin Disease?

What does the 'B' modifying characteristic refer to in the Ann Arbor staging system?

Localized tumors are most commonly treated with ______ therapy.

Which of the following best describes leukemias?

Lymphomas are characterized by their tendency to remain localized in lymph tissues and are rarely disseminated at diagnosis.

What is the primary cell type that undergoes malignant transformation in plasma cell myeloma?

The myeloid lineage includes red blood cells, platelets, monocytes, and __________.

Which category of hematologic neoplasms includes B cells, T cells, and natural killer (NK) cells?

Match the following characteristics with the correct type of malignant disorder:

In hematologic neoplasms, the classification is based on the _____ of the neoplasm.

What is the optimal initial therapy for Plasma Cell Myeloma?

Hodgkin disease is more common in females and also has a worse prognosis for them.

What type of cells characterize Hodgkin disease?

Hodgkin disease usually metastasizes along contiguous __________ pathways.

Approximately what percentage of malignant lymphomas does Hodgkin disease represent?

The histologic pattern of Hodgkin disease is a strong predictor of prognosis.

What virus is frequently found in the genome of transformed Reed–Sternberg cells?

The classical type of Hodgkin disease accounts for approximately _____ % of diagnoses.

What is the overall 5-year survival rate for all stages of treated Hodgkin disease?

What is a characteristic of malignant plasma cells in multiple myeloma?

Bence Jones proteins are heavy-chain antibody fragments.

What is the typical range of plasma cell occupation in bone marrow that confirms a diagnosis of multiple myeloma?

The accumulation of Bence Jones proteins in the blood and urine can help to _________ the diagnosis of multiple myeloma.

Match the following diagnostic findings with their clinical implications in multiple myeloma:

What is a common consequence of bone destruction in multiple myeloma?

Malignant plasma cells typically accumulate in the bloodstream, not in the bone.

What specific test is used to detect monoclonal antibodies in the bloodstream?

Pathological fractures are a common complication in multiple myeloma due to the accumulation of malignant plasma cells in the ________.

What is the premalignant stage of plasma cell myeloma called?

Bone pain is often the first symptom of plasma cell myeloma.

What percentage of individuals with MGUS progress to a malignant plasma cell disease?

Multiple myeloma diagnosis may occur when routine examination reveals high ______ levels.

What is one common characteristic of bone involvement in plasma cell myeloma as seen on X-rays?

Autologous stem cell transplantation is not a considered treatment for plasma cell myeloma.

Which of the following is NOT typically associated with bone marrow depression in multiple myeloma?

What is a major contributing factor to renal insufficiency in multiple myeloma?

The presence of _______ in urine is a potential diagnostic indicator of plasma cell myeloma.

Match the following factors with their potential association to renal complications in multiple myeloma: