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Questions and Answers
What is the function of colony-stimulating factors (CSFs)?
What is the function of colony-stimulating factors (CSFs)?
- Inhibit the production of new leukocytes
- Regulate the production of red blood cells
- Stimulate the growth of leukocyte colonies in culture (correct)
- Block the differentiation of stem cells
What is the effect of cytokines released by active leukocytes fighting a bacterial infection?
What is the effect of cytokines released by active leukocytes fighting a bacterial infection?
- Inhibit the action of existing leukocytes
- Decrease the production of white blood cells
- Stimulate the production of additional neutrophils and monocytes (correct)
- Promote the growth of red blood cells
What happens to a leukocyte once it matures?
What happens to a leukocyte once it matures?
- It becomes more vulnerable to infections
- It regains its stem cell properties
- It loses its ability to undergo mitosis (correct)
- It continues to undergo constant cell division
How do clinicians use a differential white cell count to help with diagnosis?
How do clinicians use a differential white cell count to help with diagnosis?
What is the composition of most adult hemoglobin (HbA)?
What is the composition of most adult hemoglobin (HbA)?
Where is about 70% of the iron in the body found?
Where is about 70% of the iron in the body found?
How is iron absorbed in the small intestine?
How is iron absorbed in the small intestine?
What carrier protein binds iron and transports it in the blood?
What carrier protein binds iron and transports it in the blood?
Where are the excess iron stores found in the body?
Where are the excess iron stores found in the body?
What are the initial symptoms of iron toxicity in children?
What are the initial symptoms of iron toxicity in children?
What is the primary function of red blood cells?
What is the primary function of red blood cells?
What is the function of erythropoietin (EPO)?
What is the function of erythropoietin (EPO)?
What is the role of Thrombopoietin (TPO)?
What is the role of Thrombopoietin (TPO)?
What is the primary site of Erythropoietin (EPO) production in adults?
What is the primary site of Erythropoietin (EPO) production in adults?
Which diseases are characterized by either a lack or an excess of leukocytes?
Which diseases are characterized by either a lack or an excess of leukocytes?
What stimulates the production of a transcription factor called hypoxia-inducible factor 1 (HIF-1)?
What stimulates the production of a transcription factor called hypoxia-inducible factor 1 (HIF-1)?
What are scientists currently monitoring to ensure they do not increase the likelihood of developing hematological diseases?
What are scientists currently monitoring to ensure they do not increase the likelihood of developing hematological diseases?
What was one reason for the delay in identifying Erythropoietin (EPO)?
What was one reason for the delay in identifying Erythropoietin (EPO)?
What was one breakthrough after isolating the Erythropoietin (EPO) gene?
What was one breakthrough after isolating the Erythropoietin (EPO) gene?
What is the primary site of Thrombopoietin (TPO) production?
What is the primary site of Thrombopoietin (TPO) production?
What are patients with neutropenias unable to fight off?
What are patients with neutropenias unable to fight off?
What cytokine was first described in 1958 but its gene was not cloned until 1994?
What cytokine was first described in 1958 but its gene was not cloned until 1994?
What is the normal range of hematocrit for a man?
What is the normal range of hematocrit for a man?
What is the primary source of ATP for mature red blood cells?
What is the primary source of ATP for mature red blood cells?
What happens to the nucleus of the erythroblast as it matures?
What happens to the nucleus of the erythroblast as it matures?
What is the shape of mature mammalian red blood cells in an isotonic solution?
What is the shape of mature mammalian red blood cells in an isotonic solution?
What allows red blood cells to change shape as they pass through narrow capillaries?
What allows red blood cells to change shape as they pass through narrow capillaries?
What causes red blood cells to shrink up and develop a spiky surface in hypertonic media?
What causes red blood cells to shrink up and develop a spiky surface in hypertonic media?
What does spherocytosis refer to in relation to red blood cells?
What does spherocytosis refer to in relation to red blood cells?
In which disease state do red blood cells lose their flattened disk shape and become spherical?
In which disease state do red blood cells lose their flattened disk shape and become spherical?
What is the main role of hemoglobin in red blood cells?
What is the main role of hemoglobin in red blood cells?
What is the structure of hemoglobin?
What is the structure of hemoglobin?
Which type of medium causes red blood cells to swell and form a sphere without disruption of its membrane integrity?
Which type of medium causes red blood cells to swell and form a sphere without disruption of its membrane integrity?
What happens to erythroblasts in the last stage before maturation?
What happens to erythroblasts in the last stage before maturation?
What can provide clues to the presence of disease in red blood cells?
What can provide clues to the presence of disease in red blood cells?
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