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Lecture 2.2b - Common valve pathologies

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8 Questions

Which of the following heart valves is auscultated at the lower left sternal border, 5th intercostal space?

Tricuspid valve

What is the most common cause of abnormal valve function?

Rheumatic fever

What is the result of aortic valve stenosis on the left ventricle?

Increased left ventricular afterload

What type of murmur is heard in aortic valve stenosis?

Ejection systolic murmur

What is the effect of aortic valve regurgitation on the pulse pressure?

Wide, bounding pulse pressure

What is the complication of mitral valve stenosis on the oesophagus?

Compression of the oesophagus

What is the effect of mitral valve stenosis on the right ventricle?

Right ventricular hypertrophy

What is the condition resulting from shear stress in aortic valve stenosis?

Microangiopathic haemolytic anaemia

Study Notes

Auscultation of Heart Valves

  • Aortic valve: right eternal border, 2nd intercostal space
  • Pulmonic valve: left eternal border, 2nd intercostal space
  • Tricuspid valve: lower left sternal border, 5th intercostal space
  • Mitral valve: apex, 5th intercostal space, mid-clavicular line

Abnormal Valve Function

  • Stenosis: valve doesn't open enough, resulting in murmurs
  • Regurgitation: valve doesn't close properly, resulting in murmurs
  • Common causes: rheumatic fever, infective endocarditis, myocardial infarction, congenital
  • Common valves affected: aortic and mitral

Aortic Valve Stenosis

  • Pathophysiology:
    • Reduced blood flow through valve to outflow tract
    • Increased LV pressure
    • LV hypertrophy and increased left ventricular afterload
    • Left-sided heart failure, leading to syncope and angina
    • Microangiopathic haemolytic anaemia due to shear stress
  • Murmur:
    • Ejection systolic murmur loudest over the aortic area
    • Narrow pulse pressure - crescendo decrescendo murmur

Aortic Valve Regurgitation

  • Pathophysiology:
    • Blood leaks back to ventricles in diastole
    • Increased stroke volume for subsequent cardiac cycles
    • LV hypertrophy due to increased workload
  • Murmur:
    • Early diastolic murmur loudest over aortic area
    • Wide, bounding pulse
    • Displaced apex beat

Mitral Valve Stenosis

  • Pathophysiology:
    • Reduced blood flow from LA to LV
    • Increased LA pressure, leading to pulmonary hypertension and RV hypertrophy
    • LA dilation, leading to atrial fibrillation and thrombus formation
    • LA dilation, leading to oesophagus compression

Learn the locations for auscultating heart valves and the types of abnormal valve functions, including stenosis and regurgitation, and their causes.

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