Heart Failure Pharmacology Overview

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Questions and Answers

What imaging characteristic is associated with hypersensitivity pneumonitis?

  • Tree in bud appearance
  • Finger in glove appearance
  • Tram track appearance
  • Mosaic pattern (correct)

Which treatment is considered the first choice for hypersensitivity pneumonitis?

  • Bronchodilators
  • Omalizumab
  • Itraconazole
  • Steroids (correct)

What type of hypersensitivity is primarily involved in hypersensitivity pneumonitis?

  • Type 3 hypersensitivity (correct)
  • Type 1 hypersensitivity
  • Type 2 hypersensitivity
  • Type 4 hypersensitivity (correct)

Which of the following is NOT a characteristic of hypersensitivity pneumonitis?

<p>Eosinophil presence (D)</p> Signup and view all the answers

Which imaging finding is specifically indicative of central bronchiectasis in hypersensitivity pneumonitis?

<p>Tree in bud pattern (B)</p> Signup and view all the answers

What is the mechanism of action of Ivabradine?

<p>Inhibits funny currents (Na+) (B)</p> Signup and view all the answers

Which of the following best describes diastolic dysfunction?

<p>Filling defect with normal systolic function (A)</p> Signup and view all the answers

What conditions are most commonly associated with restrictive cardiomyopathy?

<p>Hemochromatosis and amyloidosis (C)</p> Signup and view all the answers

Which symptom is typically associated with right-sided heart failure due to diastolic dysfunction?

<p>Ascites (D)</p> Signup and view all the answers

What is a major complication of chronic constrictive pericarditis?

<p>Restricted diastolic filling (D)</p> Signup and view all the answers

In acute pericarditis, which ECG finding is characteristic?

<p>Global ST elevation except in lead V1 (A)</p> Signup and view all the answers

What is a common cause of chronic constrictive pericarditis?

<p>Post-viral infections (B)</p> Signup and view all the answers

Which of the following is NOT a recognized cause of restrictive cardiomyopathy?

<p>HIV infection (D)</p> Signup and view all the answers

What is the characteristic finding in atrial tachycardia?

<p>P wave just after T wave (C)</p> Signup and view all the answers

Which medication is typically used for managing AVNRT?

<p>Adenosine (B)</p> Signup and view all the answers

Which of the following cannot be considered a type of atrial fibrillation?

<p>Transient (C)</p> Signup and view all the answers

What is a common complication of atrial fibrillation?

<p>Thromboembolism (C)</p> Signup and view all the answers

How is hemodynamically unstable atrial fibrillation primarily managed?

<p>DC cardioversion (A)</p> Signup and view all the answers

Which of the following features is not associated with atrial fibrillation?

<p>Identifiable P waves (C)</p> Signup and view all the answers

What is noted about multifocal atrial tachycardia?

<p>It shows 3 different morphologically abnormal P waves (C)</p> Signup and view all the answers

In the case of an unresponsive patient in ventricular fibrillation, what treatment is appropriate?

<p>Defibrillation (C)</p> Signup and view all the answers

Which leads correspond to the high lateral wall of the heart?

<p>I, aVL (C)</p> Signup and view all the answers

What findings are indicative of an extensive antero high lateral myocardial infarction?

<p>ST elevation in V2, V3, V4 (B)</p> Signup and view all the answers

Which condition is characterized by regular RR intervals and no P waves?

<p>AVNRT (A)</p> Signup and view all the answers

In the context of narrow QRS tachycardia, what does a long RP interval with morphologically abnormal P waves indicate?

<p>Focal atrial tachycardia (A)</p> Signup and view all the answers

Which leads are affected by LAD (D2) corresponding to the anterior wall?

<p>V2, V3, V4 (B)</p> Signup and view all the answers

Which condition is positive in Sjogren’s syndrome?

<p>Cryoglobulinemia type 2 (A), Cryoglobulinemia type 3 (B)</p> Signup and view all the answers

What is the characteristic finding in AVNRT during examination?

<p>P wave just outside QRS in 1/3rd of patients (B)</p> Signup and view all the answers

Which of the following leads shows ST elevation to indicate ST ↑ in I and aVL?

<p>D1 (B)</p> Signup and view all the answers

What is a characteristic feature of rheumatoid arthritis (RA) in terms of joint involvement?

<p>Inflammatory nature indicated by prolonged morning stiffness (B)</p> Signup and view all the answers

What does the term 'Golden hour' typically refer to in acute coronary syndrome management?

<p>The first medical contact (B)</p> Signup and view all the answers

Which joint is not spared in the progression of rheumatoid arthritis?

<p>PIP joint (A), DIP joint (B), 1st CMC joint (D)</p> Signup and view all the answers

What type of joint deformity is characterized by hyperextension of the PIP joint and flexion of the DIP joint?

<p>Swan neck deformity (B)</p> Signup and view all the answers

Which of the following is considered a reversible deformity in rheumatoid arthritis?

<p>Hitchhiker thumb deformity (A)</p> Signup and view all the answers

Which joints are typically spared in osteoarthritis?

<p>MCP joints (A), DIP joints (B)</p> Signup and view all the answers

What does a positive ESR and CRP indicate in rheumatoid arthritis?

<p>Markers for relapse (A)</p> Signup and view all the answers

Which arthritis type typically involves the wrist and MCP joints but spares the DIP joints?

<p>Rheumatoid arthritis (C)</p> Signup and view all the answers

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Study Notes

Ivabradine

  • Administered when heart rate exceeds 70 bpm and patient is on maximum β-blocker dosage.
  • Mechanism of action: Inhibits funny currents (Na+ channels).
  • Common side effect: Visual field abnormalities.
  • Not indicated: Combination of ACE inhibitor and neprilysin inhibitor (e.g., Omapatrilat), Digoxin, ventricular dysfunction.

Heart Failure Types

  • Systolic dysfunction: Characterized by impaired pumping ability.
  • Diastolic dysfunction: Involves filling defects; typically follows systolic dysfunction.
  • Systolic issues often involve the left ventricle, while diastolic issues may involve right ventricle (RV > left ventricle (LV)).

Diastolic Dysfunction

  • Leads to elevated right ventricular end-diastolic pressure (RVEDP) and right atrial pressure (RAP).
  • Symptoms include ascites, edema, jugular venous pressure (JVP), and hepatomegaly.
  • Conditions associated: Chronic constrictive pericarditis leads to more pronounced symptoms over time.

Acute Pericarditis

  • Clinical features include elevated ST segment and chest pain.
  • ECG characteristics: Global concave ST elevation, especially in all leads except lead V1; absence of reciprocal changes; PR depression.
  • Causes: Typically post-viral (e.g., Coxsackie virus), uremia.
  • Prolonged episodes can evolve into chronic constrictive pericarditis characterized by a rigid, calcified pericardium.

Chronic Constrictive Pericarditis (CCP)

  • Result of multiple relapses of acute pericarditis.
  • Symptoms include chronic right heart failure (RHF) manifestations: cachexia, ascites, edema, hepatomegaly.
  • Differential diagnoses: Restrictive cardiomyopathy linked to interstitial or intracellular accumulation disorders (e.g., amyloidosis, hemochromatosis).

Acute Coronary Syndrome Management

  • Golden hour: Optimal intervention within 6 hours of first medical contact.
  • Diagnosis should be prioritized within this timeframe.

Narrow QRS Tachycardia

  • Classified by rhythm:
    • Regular RR interval: Consider AV nodal reentrant tachycardia (AVNRT) or AV reentrant tachycardia (AVRT).
    • Irregular RR interval: Atrial fibrillation, characterized by no identifiable P waves.
  • Management strategies vary:
    • AVNRT: First-line treatment includes adenosine; consider verapamil in COPD patients.
    • Atrial tachycardia: Treated with verapamil or β-blockers.

Atrial Fibrillation (AF)

  • Findings include irregular RR intervals and absence of identifiable P waves.
  • Classified into types:
    • Paroxysmal: Lasts less than 7 days, reverts spontaneously.
    • Persistent: Lasts more than 7 days.
    • Permanent: Structural LA dilatation >4 cm; rhythm cannot revert.
  • Complications involve risk of thromboembolism.

Hypersensitivity Pneumonitis

  • Inflammatory lung disorder; involves airway and parenchyma.
  • Characterized by absence of IgE/eosinophils; positive precipitin test.
  • Hallmarks: Non-caseating granulomas and varied HRCT density patterns, indicative of different stages of disease.

Rheumatoid Arthritis (RA)

  • Clinical features include bilateral symmetrical joint involvement (duration over 6 weeks).
  • Symptoms include inflammatory markers indicating morning stiffness.
  • Progressive deformities correlate with disease severity:
    • Reversible: Zigzag deformity; ulna deviation.
    • Irreversible: Boutonnière and swan neck deformities.

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