Heart Failure: Mechanisms and Management

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Questions and Answers

In a patient with heart failure, which compensatory mechanism is most likely to lead to increased myocardial oxygen demand, potentially causing ischemia or arrhythmias?

  • Activation of the sympathetic nervous system, increasing heart rate and contractility. (correct)
  • The kidneys activating the renin-angiotensin-aldosterone system, promoting sodium and water retention.
  • Release of natriuretic peptides leading to increased GFR and diuresis.
  • Vasodilation due to release of nitric oxide and prostaglandins.

A patient diagnosed with heart failure has an ejection fraction (EF) greater than 50%. Which type of heart failure does this patient most likely have?

  • Systolic heart failure with reduced EF (HFrEF)
  • Biventricular heart failure
  • Diastolic heart failure with preserved EF (HFpEF) (correct)
  • Right ventricular heart failure

A patient with chronic heart failure is prescribed spironolactone. What is the primary mechanism by which this medication provides a therapeutic benefit?

  • Inhibiting the conversion of angiotensin I to angiotensin II to decrease vasoconstriction.
  • Dilating arterial smooth muscle to reduce afterload.
  • Blocking the effects of aldosterone, leading to sodium and water excretion while retaining potassium. (correct)
  • Increasing the force of myocardial contraction.

A patient with a history of heart failure presents with sudden, severe dyspnea, frothy, pink-tinged sputum, and bilateral crackles on auscultation. What is the MOST appropriate initial nursing intervention?

<p>Elevate the head of the bed and administer high-flow oxygen. (B)</p> Signup and view all the answers

Which diagnostic finding is MOST indicative of right-sided heart failure?

<p>Dependent edema and jugular venous distension (JVD) (A)</p> Signup and view all the answers

What BEST describes the Frank-Starling law of the heart in the context of heart failure?

<p>Increased venous return enhances contractility up to a point, beyond which overstretching reduces contraction force. (D)</p> Signup and view all the answers

What is the underlying mechanism by which SGLT-2 inhibitors improve outcomes in heart failure?

<p>Promoting osmotic diuresis and reducing blood glucose concentrations. (B)</p> Signup and view all the answers

Which statement BEST describes ventricular remodeling in heart failure?

<p>The heart becomes stiffer, fibrotic, and less effective at pumping over time. (C)</p> Signup and view all the answers

Which of the following is a negative effect of the Renin-Angiotensin-Aldosterone System (RAAS) activation as a compensatory mechanism in heart failure?

<p>Increased myocardial oxygen demand (A)</p> Signup and view all the answers

Which intervention is MOST appropriate for a patient experiencing acute decompensated heart failure with severe fluid overload?

<p>Initiating vasoactive intravenous medications and considering advanced therapies (A)</p> Signup and view all the answers

What is the BEST explanation for why an echocardiogram is a crucial diagnostic tool in evaluating heart failure?

<p>It assesses ejection fraction, diastolic function, and valve function. (A)</p> Signup and view all the answers

What is MOST likely to result in cor pulmonale?

<p>Chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (A)</p> Signup and view all the answers

What is the physiological basis for the use of nitrates in the treatment of heart failure?

<p>To reduce preload and afterload through vasodilation. (A)</p> Signup and view all the answers

Which of the following statements accurately differentiates between acute pericarditis and myocardial infarction (MI)?

<p>Pericarditis typically presents with global ST elevation on an ECG, while MI typically presents with localized ST elevation. (B)</p> Signup and view all the answers

A patient presents with chest pain exacerbated by deep inspiration and lying flat, relieved by sitting up and leaning forward. Which of the following conditions is MOST likely indicated by these symptoms?

<p>Acute Pericarditis (A)</p> Signup and view all the answers

What is the underlying mechanism by which colchicine is thought to be effective in treating pericarditis?

<p>Inhibition of neutrophil migration into areas of inflammation (C)</p> Signup and view all the answers

Which potential complication is MOST concerning following a pericardiocentesis?

<p>Myocardial or Coronary Artery Laceration (B)</p> Signup and view all the answers

Describe the pathophysiology of the cardiac damage that can occur in Rheumatic Heart Disease.

<p>An abnormal immunologic response to streptococcal antigens that causes inflammation and scarring of heart tissues. (C)</p> Signup and view all the answers

Which of the following accurately links a clinical manifestation to infective endocarditis?

<p>Painless red spots on the palms and soles (C)</p> Signup and view all the answers

What is the MOST critical initial step in treating a patient with suspected infective endocarditis (IE)?

<p>Obtaining blood cultures from multiple sites before administering antibiotics. (B)</p> Signup and view all the answers

Why is prophylactic antibiotic administration recommended by clinicians for some patients undergoing certain procedures?

<p>To prevent transient bacteremia and reduce the risk of infective endocarditis. (A)</p> Signup and view all the answers

A definitive diagnosis of acute myocarditis BEST relies on which diagnostic test?

<p>Endomyocardial Biopsy (B)</p> Signup and view all the answers

Following an acute viral infection, a patient develops increasing fatigue, dyspnea, and peripheral edema. Which condition should be suspected?

<p>Acute myocarditis (C)</p> Signup and view all the answers

Which of the following is the MOST likely etiology of acute myocarditis?

<p>Viral Infection (A)</p> Signup and view all the answers

What is a KEY intervention in managing a patient with acute myocarditis?

<p>Strict bed rest to reduce cardiac workload. (C)</p> Signup and view all the answers

Which lab result is MOST indicative of chronic constrictive pericarditis?

<p>Negative lab results (B)</p> Signup and view all the answers

A patient with a history of IV drug use is admitted with a fever, new heart murmur, and splinter hemorrhages. What complication of infective endocarditis (IE) is MOST concerning?

<p>Systemic embolization leading to stroke or organ infarction. (C)</p> Signup and view all the answers

Why is prolonged PR interval on ECG MOST concerning with Rheumatic fever?

<p>The development of heart block (D)</p> Signup and view all the answers

Why is long term antibiotic use appropriate with infective endocarditis?

<p>To effectively remove the present bacterial infection causing IE (C)</p> Signup and view all the answers

Why is it important that someone presenting with infective endocarditis have a follow up ECHO after the initial condition is being treated?

<p>To monitor for signs of the vegetation breaking free and inflammatory markers (D)</p> Signup and view all the answers

What is the MOST appropriate method to determine the causative agent in acute pericarditis?

<p>Fluid analysis (A)</p> Signup and view all the answers

Which is the MOST reliable indicator of rheumatic heart disease

<p>Heart mumur and/or HF, Pericardidits (C)</p> Signup and view all the answers

What is a diagnostic criteria associated with the diagnosis of Rheumatic Fever?

<p>Sydenham Chorea (B)</p> Signup and view all the answers

A client returns to the clinic 2 weeks after being diagnosed with acute pericarditis. Which manifestations would suggest to the nurse that the client is developing cardiac tamponade?

<p>All of the Above (D)</p> Signup and view all the answers

Which is the MOST concerning and important educational point for the nurse to include when educating a patient being discharged with acute pericarditis?

<p>Seek immediate medical attention if having any breathing difficulties (C)</p> Signup and view all the answers

Following discharge teaching, the nurse evaluates the client's understanding of self-care measures to prevent heart failure exacerbations. Which statement by the client indicates a need for additional teaching?

<p>&quot;I should weigh myself at bedtime, before eating.&quot; (D)</p> Signup and view all the answers

A patient diagnosed with acute myocarditis is experiencing a rapid decline in cardiac function. Which of the following interventions addresses the MOST critical underlying pathophysiologic mechanism?

<p>Providing immunosuppressive therapy to reduce myocardial inflammation and prevent further damage. (C)</p> Signup and view all the answers

A patient with chronic constrictive pericarditis has developed significant ascites and peripheral edema despite maximal diuretic therapy. What surgical intervention offers the BEST long-term improvement in hemodynamics and symptom management?

<p>Pericardiectomy to remove the thickened, constricting pericardium. (B)</p> Signup and view all the answers

A patient with infective endocarditis (IE) develops a sudden, severe headache, unilateral weakness, and vision changes. What is the MOST likely underlying cause of these new findings, and what is the MOST appropriate immediate diagnostic test?

<p>Embolic stroke due to vegetation fragments, requiring emergent CT angiography of the brain. (B)</p> Signup and view all the answers

A young adult with a history of untreated streptococcal pharyngitis presents with new-onset heart failure symptoms, migratory polyarthritis, and subcutaneous nodules. Which of the following pathophysiological processes is PRIMARILY responsible for the cardiac manifestations observed in this patient?

<p>Antibody-mediated cross-reactivity targeting cardiac tissue, resulting in inflammation and valvular damage. (D)</p> Signup and view all the answers

A patient with a history of heart failure and hypertension returns for a follow-up appointment. The patient reports an unintentional weight gain of 6 pounds in the last 3 days. Recognizing the adverse effects of RAAS activation in heart failure, what medication should the provider consider FIRST?

<p>Prescribe a loop diuretic to address fluid retention and reduce preload. (C)</p> Signup and view all the answers

Flashcards

What is Heart Failure?

A complex clinical syndrome where the heart cannot pump enough blood to meet the body's needs.

Primary heart failure causes?

Chronic hypertension, coronary artery disease (CAD), valve disorders, and cardiomyopathy.

Precipitating heart failure causes?

Anemia, thyrotoxicosis/hypothyroidism, sleep apnea, pulmonary embolism, endocarditis, and dysrhythmias.

Contributing heart failure causes?

Diabetes/metabolic syndrome, age, smoking, and vascular disease.

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Starling's Law of the Heart

The strength of ventricular contraction increases when the ventricle is stretched prior to contraction.

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Starling effect

Venous return to the heart increases filling pressure of the ventricle and leads to increased stoke volume therefore contraction

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Systole

Ventricular contraction during which myocardial fibers tighten and shorten.

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Diastole

Muscle fibers lengthen, the heart dilates, and cavities fill with blood

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What is stroke volume?

Amount of blood ejected from the ventricle with each contraction.

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What is Cardiac Output?

The amount of blood pumped by the ventricle in one minute.

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What is preload?

Venous blood return to atria; filling pressure of right and left side of heart

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What is afterload?

Force of resistance that the ventricle must generate to open pulmonary or aortic valves.

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What is contractility?

Force of ventricular ejection

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What is Ejection Fraction?

The percentage of blood pumped out of the ventricle with each heartbeat divided by total.

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Location Classifications of HF

Right or left ventricle, or both (biventricular)

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Ventricular failure classification of HF?

Systolic: reduced EF(HFrEF), Diastolic: preserved EF(HFpEF)

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Systolic Heart Failure (HFrEF)

Hallmark is a reduced ejection fraction (EF) <50%.

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Systolic HF causes

MI, HTN, cardiomyopathy, valve failure

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Systolic HF Pathophysiology?

Dilation and hypertrophy, decreased Inotropy, fluid back-up into the left atrium, and increased pressure/fluid leakage into the alveoli (pulmonary edema)

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Hallmark of Diastolic HF

Preserved EF. >50%

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Causes of Diastolic HF?

HTN, old age, female, diabetes, and obesity.

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Pathophysiology of Diastolic HF?

Stiff and noncompliant left ventricle, decreased filling leads to decreased SV, increased pressure leads to fluid leakage into the alveoli (pulmonary edema).

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Clinical Manifestations of Left-Sided HF

Pulmonary edema (cough/blood-tinged sputum, bilateral crackles/rhonchi), Orthopnea, PND, Nocturia

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Clinical Manifestations - Right Sided HF

Dependent edema, anorexia, nausea/GI bloating, cyanosis of nail beds, JVD, and weight gain >2 lbs daily

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Right ventricular failure

Blood backs up into right atria, then into the venous system

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Causes of Right-Sided HF?

Left-sided heart failure (most common), right-sided MI, valve failure, PE, Cor Pulmonale (COPD, pulmonary hypertension).

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What diagnostic studies are used for HF?

Chest X-ray, 12 Lead EKG, Diagnostic R Heart Cath, Echocardiogram to assess ejection fraction

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Common Labs with HF

BNP, Cr/BUN, elctrolytes (K, Mag, Na), LFTs

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Renin-Angiotensin-Aldosterone System (RAAS)

Kidney's response to decreased CO due to decreased perfusion, it stimulates release renin which converts angiotensin I to angiotensin II. Activates SNS, aldosterone

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Sympathetic Nervous System Stimulation

Baroreceptors & vasomotor regulatory centers (Medulla) that increase circulating catecholamine's, increase HR, contractility, peripheral vasoconstriction thereby increasing CO

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Hypertrophy

Muscle mass & cardiac wall thickness increase (concentric hypertrophy); occurs slowly over time, initially effective, then problematic.

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Dilation

attempt to adapt to increase in circulating volume; initially effective (Frank-Starling law). Muscle fibers become overstretched and contraction becomes ineffective

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Ventricular Remodeling

Change in the structure of the heart over time (dimensions/mass/shape).

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Natriuretic Peptides

Hormones produced by heart muscle/released in response to volume & stretch that counteract SNS and RAAS effects.

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Nitric Oxide & Prostaglandins

Released from vascular endothelium in response to compensatory mechanisms to relax arterial smooth muscle, vasodilate & decrease afterload

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What are Inotropes?

Modify the force of contraction either + or –

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What do Beta Blockers do?

Block SNS

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What are Vasodialators?

Act on smooth muscle wall to open capillary beds

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What do Diuretics do?

Decrease circulating volume

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SGLT-2 Inhibitors action?

Osmotic diuresis by increasing urine glucose concentrations

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ACE inhibitors?

Block RAAS & stop conversion of angiotensin I to II

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ARBS

Block angiotensin II at the receptor site

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Potassium Sparing Diuretics?

Aldosterone antagonists (spironolactone/eplerenone) = spare K+ while excreting NA+ & H2O

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Neprilysin-angiotensin inhibitors?

Stop the degradation of natriuretic peptides and block RASS

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ACCF/AHA Stage A

At high risk for HF, but no heart disease or symptoms

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ACCF/AHA Stage D

Advanced heart disease with continued HF requiring specialized therapy

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