Haptens and the Immune System
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Questions and Answers

What is the process by which a B-cell clone matures into a plasma cell that secretes antibodies against the hapten?

  • Somatic hypermutation
  • Isotype switching
  • Affinity maturation
  • Clonal expansion (correct)
  • In the context of haptens modifying normal proteins to make them immunogenic, which type of protein alteration occurs?

  • Haptenation (correct)
  • Phosphorylation
  • Acetylation
  • Glycosylation
  • Which cell becomes activated when many molecules of a hapten bind to a host protein and cause cross-linking of antibodies, leading to allergic reactions like hives and bronchoconstriction?

  • Natural killer cells
  • T-helper cells
  • Mast cells (correct)
  • B-cells
  • What is the term for the process where an MHC-presented hapten-protein complex is recognized as foreign due to the modification of the protein by the hapten?

    <p>Immunogenicity</p> Signup and view all the answers

    Which process involves nonimmunogenic haptens activating cells by clustering antibodies together on a carrier protein?

    <p>Receptor cross-linking</p> Signup and view all the answers

    What role do adjuvants play in enhancing the immune response without binding to antibody or immunogen?

    <p>Enhance antigen presentation</p> Signup and view all the answers

    What is a characteristic of haptens in relation to T cell activation?

    <p>They need to be covalently bound to a carrier protein to activate T cells</p> Signup and view all the answers

    How do haptens stimulate a primary adaptive response?

    <p>By forming a complex with carrier proteins</p> Signup and view all the answers

    What is the role of helper T cells in the response to haptens?

    <p>Present peptides associated with MHC proteins to B cells</p> Signup and view all the answers

    Why can haptens not activate T cells on their own?

    <p>Because they lack immunogenicity without carrier proteins</p> Signup and view all the answers

    In what way do conjugate vaccines utilize haptens?

    <p>By conjugating them with strong immunogens</p> Signup and view all the answers

    What distinguishes haptens from antigens in terms of immunogenicity?

    <p>Antigens can elicit an immune response independently</p> Signup and view all the answers

    What is the role of helper T cells in the process of producing antibody to a hapten in conjugate vaccines?

    <p>Help stimulate B cells to produce antibody</p> Signup and view all the answers

    Why is a hapten alone incapable of inducing antibody production?

    <p>Only peptides, not haptens, can be loaded onto MHC proteins for T cell recognition</p> Signup and view all the answers

    What happens after a hapten-carrier protein complex is internalized by a B cell?

    <p>The carrier protein is processed into peptides</p> Signup and view all the answers

    How do conjugate vaccines enhance the immunogenicity of a weak hapten?

    <p>By conjugating the hapten with a strong peptide antigen</p> Signup and view all the answers

    What is the significance of T-cell recognition of carrier protein epitope in antibody production?

    <p>It prompts T helper cytokine production that stimulates B cells</p> Signup and view all the answers

    Why is the interaction between hapten and B cell insufficient for antibody induction?

    <p>Peptides are required for loading onto MHC proteins for T cell recognition</p> Signup and view all the answers

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