Halogenated natural products have unique properties.

• Halogenated natural products have unique properties.
• The biosynthetic origin of halogenation was a scientific puzzle.
• Recent studies have revealed the biological halogenating agents and enzymes responsible for halogenation.
• Halogenation can occur through multiple pathways.
• Many halogenase enzymes use electrophilic halogenating species produced by oxidation of halide ions.
• The biosynthesis of pyrrolnitrin begins with enzyme-catalyzed chlorination of tryptophan.
• The halogenase enzyme uses hypo-chlorous acid as an electrophilic chlorinating agent.
• Hydrogen bonding with a nearby amino group activates HOCl to chlorinate tryptophan.
• 7-chlorotryptophan is produced, which undergoes subsequent conversion to pyrrolnitrin.
• Pyrrolnitrin is formed through additional enzyme-catalyzed processes, including a second biochemical chlorination.

Test your knowledge on the fascinating world of halogenated natural products with this quiz! Discover the unique properties of these compounds, learn about the scientific puzzle of their biosynthetic origin, and explore the multiple pathways through which halogenation can occur. Explore the latest research on the biological halogenating agents and enzymes responsible for halogenation and dive into the specific case of the biosynthesis of pyrrolnitrin. Challenge yourself to understand the role of halogenase enzymes and electroph