Haemostasis Overview

The four primary factors involved in hemostasis are blood vessels, platelets, plasma coagulation factors, and fibrinolysis.

The primary hemostatic plug is a mass of platelets that temporarily arrests bleeding. It is considered fragile because it is easily dislodged from the vessel wall.

Fibrin reinforces the unstable platelet plug by forming a chemically stable mesh that binds the platelets together.

<p>The secondary hemostatic plug is the fibrin-reinforced plug that forms after the primary hemostatic plug. It is more stable and less likely to dislodge from the vessel wall.</p> Signup and view all the answers

<p>Fibrinolysis is the breakdown of fibrin. It is important because it ensures that the clot is removed once the wound has healed, restoring normal blood flow through the vessel.</p> Signup and view all the answers

<p>An upset in the balance of hemostasis can result in either bleeding or abnormal blood clotting (thrombosis).</p> Signup and view all the answers

<p>Platelets adhere to the exposed collagen fibers on the injured blood vessel wall and release factors that attract and activate more platelets, forming a temporary plug.</p> Signup and view all the answers

<p>The formation of fibrin, through the activation of coagulation factors, reinforces the unstable platelet plug by forming a stable mesh that entraps platelets, red blood cells and other components, creating the secondary hemostatic plug.</p> Signup and view all the answers

<p>The two greek words are &quot;haeme&quot; meaning blood and &quot;stasis&quot; meaning stop.</p> Signup and view all the answers

<p>The three major components are the endothelium, smooth muscle, and connective tissue.</p> Signup and view all the answers

<p>The 3 key components include the blood vessels, the blood, and the heart.</p> Signup and view all the answers

<p>The two main processes are coagulation and fibrinolysis.</p> Signup and view all the answers

<p>A blood clot serves as a barrier to prevent excessive blood loss from a damaged blood vessel.</p> Signup and view all the answers

<p>It's crucial to prevent the blockage of normal blood flow through the vessel and ensure proper function.</p> Signup and view all the answers

<p>The major components include 1) Plasminogen, 2) Plasmin, 3) Tissue plasminogen activator, and 4) Plasminogen activator inhibitor.</p> Signup and view all the answers

<p>Two examples of vitamin K-dependent coagulation factors are Factor II (prothrombin) and Factor VII (proconvertin).</p> Signup and view all the answers

<p>Platelets and plasma proteins work together to form a clot (thrombus) at the site of injury, which acts as a barrier to prevent further blood loss. They also limit the clot to the area of injury, preserving normal circulation in other blood vessels.</p> Signup and view all the answers

<p>The three stages of hemostasis are:</p> <ol> <li><strong>Primary hemostasis:</strong> This involves the formation of a platelet plug at the site of injury.</li> <li><strong>Secondary hemostasis:</strong> This involves the formation of a fibrin clot, which reinforces the platelet plug.</li> <li><strong>Fibrinolysis:</strong> This is the process of breaking down the fibrin clot once the injury has healed.</li> </ol> Signup and view all the answers

<p>The components of hemostasis include the vasculature (vessel wall), platelets, and proteins (coagulation factors, fibrinolytic proteins, and inhibitors).</p> Signup and view all the answers

<p>Hemostasis involves fibrin-forming proteins (responsible for forming the fibrin clot), fibrinolytic proteins (responsible for breaking down the fibrin clot), and inhibitors (which regulate the process at various stages).</p> Signup and view all the answers

<p>Vessel repair is essential for the long-term resolution of an injury. Once the clot has formed, the damaged vessel wall needs to be repaired to prevent further bleeding and restore the integrity of the circulatory system.</p> Signup and view all the answers

<p>Fibrinolysis is the process of breaking down the fibrin clot, dissolving it into smaller fragments. This occurs once the injury has healed and the clot is no longer necessary.</p> Signup and view all the answers

<p>Examples of coagulation factors include fibrinogen (factor I), prothrombin (factor II), and tissue factor (also known as factor III).</p> Signup and view all the answers

The process of stopping bleeding and maintaining blood fluidity.

The initial response to blood vessel injury, involving platelet aggregation.

The formation of a stable blood clot through coagulation cascade.

The process of breaking down a blood clot after vessel repair.

Proteins in blood that help control bleeding during hemostasis.

A coagulation pathway activated by damage to the blood vessel.

A coagulation pathway triggered by external trauma to tissue.

Coagulation factors that require vitamin K for their synthesis.

Cell fragments that play a key role in blood clotting.

A protein that forms a fibrous mesh to stabilize blood clots.

The system of blood vessels in the body.

A mass of platelets that temporarily stops bleeding after injury.

A stable plug formed by fibrin that reinforces the primary plug.

Tubes through which blood flows, playing a role in bleeding control.

The abnormal formation of blood clots inside blood vessels.