Haemoglobin
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Questions and Answers

Which type of haemoglobin is present in the highest percentage in adults?

  • Haemoglobin A1 (correct)
  • Foetal Haemoglobin
  • Haemoglobin A2
  • Haemoglobin with Delta type subunits
  • How many haem groups are present in Haemoglobin A1?

  • 2
  • 4 (correct)
  • 1
  • 3
  • Which type of haemoglobin has two Alpha type and two Gamma type subunits?

  • Haemoglobin A1
  • Haemoglobin with Delta type subunits
  • Foetal Haemoglobin (correct)
  • Haemoglobin A2
  • What is the state of the iron atom when it associates with O2?

    <p>Fe2+</p> Signup and view all the answers

    What happens to the shape of other subunits when the haem group in the 'relaxed' state binds to oxygen?

    <p>They become more flexible</p> Signup and view all the answers

    Which of the following conditions would cause a leftward shift in the haemoglobin-oxygen dissociation curve?

    <p>Decrease in temperature</p> Signup and view all the answers

    What effect does an increase in 2-3 DPG levels have on the haemoglobin-oxygen dissociation curve?

    <p>Shifts the curve to the right</p> Signup and view all the answers

    Which of the following conditions would cause a decrease in the affinity of haemoglobin for oxygen?

    <p>Decreased pH</p> Signup and view all the answers

    What is the role of increased CO2 in shifting the curves?

    <p>Destabilizes interaction of hemoglobin with O2</p> Signup and view all the answers

    Which molecule interacts with amino acids on b chains and destabilizes the interaction of hemoglobin with O2?

    <p>2-3-Diphosphoglycerate</p> Signup and view all the answers

    What effect does altitude training have on 2-3-Diphosphoglycerate levels?

    <p>Increases levels of 2-3-Diphosphoglycerate</p> Signup and view all the answers

    How does an increase in 2,3-diphosphoglycerate (2,3-DPG) affect oxygen release by hemoglobin?

    <p>It increases oxygen release.</p> Signup and view all the answers

    What effect does an increase in temperature have on the haemoglobin-oxygen dissociation curve?

    <p>Rightward shift</p> Signup and view all the answers

    How does a shift in the oxygen-hemoglobin dissociation curve relate to hypoxia?

    <p>A rightward shift in the curve decreases oxygen affinity and can lead to hypoxia.</p> Signup and view all the answers

    Which form of carbon dioxide is the most abundant in the blood?

    <p>Bicarbonate</p> Signup and view all the answers

    When carbon dioxide (CO2) enters red blood cells (RBCs), what percentage of it forms compounds with hemoglobin?

    <p>21%</p> Signup and view all the answers

    Which enzyme catalyzes the formation of bicarbonate and H+ from carbon dioxide in the red blood cells?

    <p>Carbonic anhydrase</p> Signup and view all the answers

    How much carbon dioxide is picked up through capillaries in the blood?

    <p>4ml/dL</p> Signup and view all the answers

    Which ion enters the cell down its concentration gradient during the chloride shift?

    <p>HCO3-</p> Signup and view all the answers

    What is the product of the reaction between bicarbonate and hydrogen ions?

    <p>H2CO3</p> Signup and view all the answers

    What triggers the release of hydrogen ions from hemoglobin in the alveoli which helps in unloading carbon dioxide (CO2)?

    <p>High pO2</p> Signup and view all the answers

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