31 Questions
What is the main objective of the lecture on Haematopoiesis and Anaemias?
To indicate the main diagnostic approaches to blood diseases and anaemia
Which book is suggested for further reading on the topic?
Hoffbrand’s Essential Haematology, 8th ed, John Wiley & Sons Ltd. Chapter 2
In which part of the lecture is the Physiology of red blood cells discussed?
Part 1: Physiology of red blood cells (slides 5-13)
What is the role of Reticulocyte in Anaemia diagnosis?
To assist in the diagnosis of anaemia by measuring immature red blood cells
What does Part 3 of the lecture cover?
Main types of anaemia including sickle cell anaemia
Which part of the lecture discusses Anaemia classification and diagnosis?
Part 2: Anaemias classification and diagnosis (slides 14-34)
What is the main oxygen-binding protein in the body?
Hemoglobin
Which organelle is notably absent in mature erythrocytes (RBCs)?
Mitochondria
What is the primary reason why developing RBCs (erythroblasts) need to synthesize heme?
To transport oxygen
Which lineage is responsible for the production of red blood cells?
Myeloid lineage
What is the term for the process by which non-mature stem cells transform into mature functional blood cells?
Maturation
Which vitamin deficiency can cause anaemia due to its role as a cofactor in heme synthesis?
Vitamin B12
What condition results from the oxidation of Fe2+ into Fe3+ in heme?
Methemoglobinemia
What is the main site for erythropoiesis in adult humans?
Bone marrow
In what form is iron (Fe) present in heme?
Ferrous (Fe2+)
Which type of blood cell does not originate from the myeloid lineage?
B cells
In haemostasis, what is the main function of platelets?
Prevent excessive bleeding
Where are platelets produced in the body?
Bone marrow
What is the normal lifespan of platelets in the body?
7-10 days
What is the primary role of fibrin mesh in haemostasis?
Prevent excessive bleeding
Which process leads to the formation of platelets from megakaryocytes?
Fragmentation
What is the key function of vascular spasm in haemostasis?
Minimize blood flow to the injured area
In the platelet phase of haemostasis, what is the role of Von Willebrand factor?
It binds to collagen to which platelets adhere
What substances can cause platelets to aggregate during the platelet phase of haemostasis?
Adenosine diphosphate (ADP), thrombin, and tissue factor
Which pathway is termed 'extrinsic' in the coagulation cascade?
Tissue factor pathway
What is the term for the enzyme proteolysis of fibrin in fibrinolysis?
Plasmin
Which coagulation cascade factor is involved in the generation of Factor Xa in the extrinsic pathway?
Factor VII
What is the term for the lab test that activates/standardizes/speeds up the intrinsic pathway in the coagulation cascade?
Activated Partial Thromboplastin Time (APTT)
Which enzyme is responsible for generating plasmin in fibrinolysis?
Tissue Plasminogen Activator (t-PA)
What does TF stand for in the context of the coagulation cascade?
Tissue Factor
Which substance binds and activates Factor VII in the extrinsic pathway of the coagulation cascade?
Calcium and phospholipid
Learn about Red blood cell Biology, diagnostic approaches to blood diseases and anaemia, and the pathology, diagnosis, and treatment of different types of anaemias in this lecture. Recommended reading includes 'Hoffbrand’s Essential Haematology, 8th ed, John Wiley & Sons Ltd.' Chapter 2.
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