Haematopoiesis and Anaemias Lecture
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Questions and Answers

What is the main objective of the lecture on Haematopoiesis and Anaemias?

  • To indicate the main diagnostic approaches to blood diseases and anaemia (correct)
  • To discuss the structure and function of red blood cells
  • To provide an overview of the main types of anaemias
  • To delve into the pathology, diagnosis, and treatment of anaemias
  • Which book is suggested for further reading on the topic?

  • Hoffbrand’s Essential Haematology, 8th ed, John Wiley & Sons Ltd. Chapter 2 (correct)
  • Hoffbrand’s Essential Haematology, 6th ed, John Wiley & Sons Ltd.
  • G. Moore, Haematology, Oxford University Press Chapters 2, 4
  • Links embedded
  • In which part of the lecture is the Physiology of red blood cells discussed?

  • Part 3: Main types of anaemia (slides 35-62)
  • Part 1: Physiology of red blood cells (slides 5-13) (correct)
  • There is no specific part for discussing the Physiology of red blood cells
  • Part 2: Anaemias classification and diagnosis (slides 14-34)
  • What is the role of Reticulocyte in Anaemia diagnosis?

    <p>To assist in the diagnosis of anaemia by measuring immature red blood cells</p> Signup and view all the answers

    What does Part 3 of the lecture cover?

    <p>Main types of anaemia including sickle cell anaemia</p> Signup and view all the answers

    Which part of the lecture discusses Anaemia classification and diagnosis?

    <p>Part 2: Anaemias classification and diagnosis (slides 14-34)</p> Signup and view all the answers

    What is the main oxygen-binding protein in the body?

    <p>Hemoglobin</p> Signup and view all the answers

    Which organelle is notably absent in mature erythrocytes (RBCs)?

    <p>Mitochondria</p> Signup and view all the answers

    What is the primary reason why developing RBCs (erythroblasts) need to synthesize heme?

    <p>To transport oxygen</p> Signup and view all the answers

    Which lineage is responsible for the production of red blood cells?

    <p>Myeloid lineage</p> Signup and view all the answers

    What is the term for the process by which non-mature stem cells transform into mature functional blood cells?

    <p>Maturation</p> Signup and view all the answers

    Which vitamin deficiency can cause anaemia due to its role as a cofactor in heme synthesis?

    <p>Vitamin B12</p> Signup and view all the answers

    What condition results from the oxidation of Fe2+ into Fe3+ in heme?

    <p>Methemoglobinemia</p> Signup and view all the answers

    What is the main site for erythropoiesis in adult humans?

    <p>Bone marrow</p> Signup and view all the answers

    In what form is iron (Fe) present in heme?

    <p>Ferrous (Fe2+)</p> Signup and view all the answers

    Which type of blood cell does not originate from the myeloid lineage?

    <p>B cells</p> Signup and view all the answers

    In haemostasis, what is the main function of platelets?

    <p>Prevent excessive bleeding</p> Signup and view all the answers

    Where are platelets produced in the body?

    <p>Bone marrow</p> Signup and view all the answers

    What is the normal lifespan of platelets in the body?

    <p>7-10 days</p> Signup and view all the answers

    What is the primary role of fibrin mesh in haemostasis?

    <p>Prevent excessive bleeding</p> Signup and view all the answers

    Which process leads to the formation of platelets from megakaryocytes?

    <p>Fragmentation</p> Signup and view all the answers

    What is the key function of vascular spasm in haemostasis?

    <p>Minimize blood flow to the injured area</p> Signup and view all the answers

    In the platelet phase of haemostasis, what is the role of Von Willebrand factor?

    <p>It binds to collagen to which platelets adhere</p> Signup and view all the answers

    What substances can cause platelets to aggregate during the platelet phase of haemostasis?

    <p>Adenosine diphosphate (ADP), thrombin, and tissue factor</p> Signup and view all the answers

    Which pathway is termed 'extrinsic' in the coagulation cascade?

    <p>Tissue factor pathway</p> Signup and view all the answers

    What is the term for the enzyme proteolysis of fibrin in fibrinolysis?

    <p>Plasmin</p> Signup and view all the answers

    Which coagulation cascade factor is involved in the generation of Factor Xa in the extrinsic pathway?

    <p>Factor VII</p> Signup and view all the answers

    What is the term for the lab test that activates/standardizes/speeds up the intrinsic pathway in the coagulation cascade?

    <p>Activated Partial Thromboplastin Time (APTT)</p> Signup and view all the answers

    Which enzyme is responsible for generating plasmin in fibrinolysis?

    <p>Tissue Plasminogen Activator (t-PA)</p> Signup and view all the answers

    What does TF stand for in the context of the coagulation cascade?

    <p>Tissue Factor</p> Signup and view all the answers

    Which substance binds and activates Factor VII in the extrinsic pathway of the coagulation cascade?

    <p>Calcium and phospholipid</p> Signup and view all the answers

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