Haematopoiesis and Anaemias Lecture

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Questions and Answers

What is the main objective of the lecture on Haematopoiesis and Anaemias?

  • To indicate the main diagnostic approaches to blood diseases and anaemia (correct)
  • To discuss the structure and function of red blood cells
  • To provide an overview of the main types of anaemias
  • To delve into the pathology, diagnosis, and treatment of anaemias

Which book is suggested for further reading on the topic?

  • Hoffbrand’s Essential Haematology, 8th ed, John Wiley & Sons Ltd. Chapter 2 (correct)
  • Hoffbrand’s Essential Haematology, 6th ed, John Wiley & Sons Ltd.
  • G. Moore, Haematology, Oxford University Press Chapters 2, 4
  • Links embedded

In which part of the lecture is the Physiology of red blood cells discussed?

  • Part 3: Main types of anaemia (slides 35-62)
  • Part 1: Physiology of red blood cells (slides 5-13) (correct)
  • There is no specific part for discussing the Physiology of red blood cells
  • Part 2: Anaemias classification and diagnosis (slides 14-34)

What is the role of Reticulocyte in Anaemia diagnosis?

<p>To assist in the diagnosis of anaemia by measuring immature red blood cells (C)</p> Signup and view all the answers

What does Part 3 of the lecture cover?

<p>Main types of anaemia including sickle cell anaemia (A)</p> Signup and view all the answers

Which part of the lecture discusses Anaemia classification and diagnosis?

<p>Part 2: Anaemias classification and diagnosis (slides 14-34) (B)</p> Signup and view all the answers

What is the main oxygen-binding protein in the body?

<p>Hemoglobin (D)</p> Signup and view all the answers

Which organelle is notably absent in mature erythrocytes (RBCs)?

<p>Mitochondria (C)</p> Signup and view all the answers

What is the primary reason why developing RBCs (erythroblasts) need to synthesize heme?

<p>To transport oxygen (B)</p> Signup and view all the answers

Which lineage is responsible for the production of red blood cells?

<p>Myeloid lineage (C)</p> Signup and view all the answers

What is the term for the process by which non-mature stem cells transform into mature functional blood cells?

<p>Maturation (B)</p> Signup and view all the answers

Which vitamin deficiency can cause anaemia due to its role as a cofactor in heme synthesis?

<p>Vitamin B12 (C)</p> Signup and view all the answers

What condition results from the oxidation of Fe2+ into Fe3+ in heme?

<p>Methemoglobinemia (A)</p> Signup and view all the answers

What is the main site for erythropoiesis in adult humans?

<p>Bone marrow (B)</p> Signup and view all the answers

In what form is iron (Fe) present in heme?

<p>Ferrous (Fe2+) (B)</p> Signup and view all the answers

Which type of blood cell does not originate from the myeloid lineage?

<p>B cells (D)</p> Signup and view all the answers

In haemostasis, what is the main function of platelets?

<p>Prevent excessive bleeding (D)</p> Signup and view all the answers

Where are platelets produced in the body?

<p>Bone marrow (C)</p> Signup and view all the answers

What is the normal lifespan of platelets in the body?

<p>7-10 days (C)</p> Signup and view all the answers

What is the primary role of fibrin mesh in haemostasis?

<p>Prevent excessive bleeding (C)</p> Signup and view all the answers

Which process leads to the formation of platelets from megakaryocytes?

<p>Fragmentation (D)</p> Signup and view all the answers

What is the key function of vascular spasm in haemostasis?

<p>Minimize blood flow to the injured area (A)</p> Signup and view all the answers

In the platelet phase of haemostasis, what is the role of Von Willebrand factor?

<p>It binds to collagen to which platelets adhere (B)</p> Signup and view all the answers

What substances can cause platelets to aggregate during the platelet phase of haemostasis?

<p>Adenosine diphosphate (ADP), thrombin, and tissue factor (B)</p> Signup and view all the answers

Which pathway is termed 'extrinsic' in the coagulation cascade?

<p>Tissue factor pathway (D)</p> Signup and view all the answers

What is the term for the enzyme proteolysis of fibrin in fibrinolysis?

<p>Plasmin (C)</p> Signup and view all the answers

Which coagulation cascade factor is involved in the generation of Factor Xa in the extrinsic pathway?

<p>Factor VII (D)</p> Signup and view all the answers

What is the term for the lab test that activates/standardizes/speeds up the intrinsic pathway in the coagulation cascade?

<p>Activated Partial Thromboplastin Time (APTT) (B)</p> Signup and view all the answers

Which enzyme is responsible for generating plasmin in fibrinolysis?

<p>Tissue Plasminogen Activator (t-PA) (A)</p> Signup and view all the answers

What does TF stand for in the context of the coagulation cascade?

<p>Tissue Factor (C)</p> Signup and view all the answers

Which substance binds and activates Factor VII in the extrinsic pathway of the coagulation cascade?

<p>Calcium and phospholipid (A)</p> Signup and view all the answers

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