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Questions and Answers

What characterizes caseous necrosis?

  • Necrosis of fat cells
  • Inflamed blood vessels
  • Firm tissue without cellular details (correct)
  • Excessive bleeding in organs
  • Which condition is most associated with fat necrosis?

  • Acute hemorrhagic pancreatitis (correct)
  • Malignant hypertension
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Which factor does NOT lead to fibrinoid necrosis?

  • Subacute bacterial endocarditis
  • Viral hepatitis (correct)
  • Malignant hypertension
  • Autoimmune diseases
  • What morphological change does NOT occur during apoptosis?

    <p>Cell swelling</p> Signup and view all the answers

    Which of the following is NOT an example of pathological apoptosis?

    <p>Hormone-dependent involution</p> Signup and view all the answers

    Which cellular change occurs first during apoptosis?

    <p>Cytoplasmic shrinkage</p> Signup and view all the answers

    What is a common feature of fibrinoid necrosis?

    <p>It affects the inner layer of small blood vessels.</p> Signup and view all the answers

    What characterizes necrosis in terms of cell death?

    <p>It involves local death of a group of cells.</p> Signup and view all the answers

    Which morphological feature indicates coagulation necrosis?

    <p>Preservation of cell outlines.</p> Signup and view all the answers

    What is karyolysis?

    <p>Disappearance of the nucleus due to chromatin hydrolysis.</p> Signup and view all the answers

    Which type of necrosis is characterized by a creamy appearance due to fat breakdown?

    <p>Fat necrosis.</p> Signup and view all the answers

    What does liquefactive necrosis primarily result from?

    <p>Hydrolytic enzymes causing tissue liquefaction.</p> Signup and view all the answers

    Which of the following necroses is associated with a caseous appearance?

    <p>Caseation necrosis.</p> Signup and view all the answers

    Which type of necrosis includes both autolysis and heterolysis processes?

    <p>Liquefactive necrosis.</p> Signup and view all the answers

    Pyknosis describes which nuclear change during necrosis?

    <p>Shrinking and increased basophilia of the nucleus.</p> Signup and view all the answers

    Study Notes

    Cell Injury - 3

    • Study objectives include recalling cell death types, describing necrotic cell types, examples, and morphological features, describing apoptotic cell morphology and types, and comparing necrotic and apoptotic cells.

    Types of Cell Death

    • Necrosis: Local death of a group of cells within the living body. It's a pathological process.
    • Apoptosis: Genetically controlled, programmed, single cell death. Often a physiological process.

    Necrosis

    • Grossly: The necrotic area is well-defined, swollen, opaque, pale yellow or pale red, surrounded by a red zone of inflammatory hyperemia.
    • Microscopically:
      • Cell membrane disappears, and cells become indistinct from each other.
      • Cytoplasm swells and coagulates, appearing homogenous and deeply eosinophilic.
      • Nucleus:
        • Pyknosis: the nucleus shrinks and becomes deeply basophilic.
        • Karyorrhexis: the nucleus fragments.
        • Karyolysis: the nucleus disappears due to chromatin hydrolysis.

    Types of Necrosis

    • Coagulative necrosis: Denaturation and coagulation of structural and enzymatic proteins. Preserves cell outlines and tissue architecture. Examples include myocardial infarction due to coronary artery occlusion.
    • Liquefactive necrosis: Necrosis with complete loss of cell and tissue structure due to liquefaction by hydrolytic enzymes. Examples are ischemic necrosis of brain (infarction) and pyogenic abscess.
    • Caseous necrosis: A combination of coagulative and liquefactive necrosis. The tissue is firm (grossly) and lacks cellular details or tissue outline (microscopically). An example is tuberculosis.
    • Fat necrosis: Necrosis of fat cells, either from trauma to fatty tissue or the action of lipase enzyme, Often results in whitish yellow nodules. Examples include traumatic fat necrosis of the breast and enzymatic fat necrosis of the pancreas and omentum in case of pancreatitis.
    • Fibrinoid necrosis: Death of cells in the inner layer of small blood vessels. Can lead to bleeding and internal damage throughout the body. Causes can include malignant hypertension, autoimmune diseases (like rheumatoid arthritis and systemic lupus erythematosus), subacute bacterial endocarditis, and vasculitis (like polyarteritis nodosa)..

    Apoptosis

    • Morphologic appearance:
      • Cell shrinkage
      • Deeply eosinophilic cytoplasm
      • Pyknotic nucleus, then fragmentation
      • Intact cell membrane
      • Formation of cytoplasmic buds
      • Each nuclear fragment forms with a cytoplasmic bud and breaks off to form apoptotic bodies,
      • Phagocytosis of apoptotic bodies by adjacent cells or macrophages.
      • Lack of inflammatory response
    • Physiological examples:
      • Embryogenesis (development of lumens)
      • Hormone-dependent involution in adults (e.g., breast size change after lactation, uterine involution after delivery)
      • Removal of self-reacting T-lymphocytes in the thymus
    • Pathological examples:
      • Councilman bodies (apoptotic hepatocytes in viral hepatitis)
      • Tumor cell death
      • Neurons lost in Alzheimer's disease
      • HIV-positive T-lymphocytes

    Apoptosis vs. Necrosis

    Feature Necrosis Apoptosis
    Cell size Enlarged (swelling) Reduced (shrinkage)
    Nucleus Pyknosis, karyorrhexis, karyolysis Fragmentation
    Cellular contents Enzymatic digestion; may leak out of cell Intact, may be released in apoptotic bodies
    Adjacent inflammation Frequent No
    Physiological/pathological role Always pathological Often physiological, may be pathological

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