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Questions and Answers
What is the molecular weight of Growth Hormone (GH)?
What is the molecular weight of Growth Hormone (GH)?
What percentage of Growth Hormone is derived from the smaller mRNA isoform that omits the first section of exon III?
What percentage of Growth Hormone is derived from the smaller mRNA isoform that omits the first section of exon III?
During which condition is the release of Growth Hormone likely to increase?
During which condition is the release of Growth Hormone likely to increase?
Which of the following factors does NOT influence the release of Growth Hormone?
Which of the following factors does NOT influence the release of Growth Hormone?
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What is the primary site of production for Growth Hormone?
What is the primary site of production for Growth Hormone?
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Study Notes
Growth Hormone (GH) Structure and Characteristics
- Growth Hormone (GH) is a 191 amino acid peptide hormone.
- Its molecular weight is approximately 22 kDa.
- GH has a similar structure to prolactin and chorionic somatomammotropin (placental hormone).
- Two isoforms of GH exist, produced by alternative splicing.
- Most GH isoforms include all 5 exons, translated into a 191 amino acid protein of 22 kDa.
- 10-15% of GH is derived from smaller mRNA molecules, omitting the first section of exon III.
Production and Release of GH
- GH is produced by somatotrophs in the anterior pituitary gland.
- GH release occurs in pulsatile bursts throughout the day.
- GH release is largely prominent during nighttime (deep sleep).
- Exercise and trauma also increase GH release.
Factors Influencing GH Release
- Nutritional status influences GH release.
- Metabolic conditions influence GH release.
- Age-related sex steroids influence GH release.
- Adrenal glucocorticoids influence GH release.
- Thyroid hormones influence GH release.
- Renal function influences GH release.
- Hepatic function influences GH release.
Circulation of GH
- Normal circulating levels of GH (specific value omitted in the provided text).
- The provided text does not describe the details of GH binding.
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Description
This quiz covers the structure, production, and release of Growth Hormone (GH). It explores its characteristics, isoforms, and factors influencing its release. Test your knowledge on this important peptide hormone and its physiological roles.
