Podcast
Questions and Answers
What is the molecular weight of Growth Hormone (GH)?
What is the molecular weight of Growth Hormone (GH)?
- 15 kDA
- 22 kDA (correct)
- 35 kDA
- 5 kDA
What percentage of Growth Hormone is derived from the smaller mRNA isoform that omits the first section of exon III?
What percentage of Growth Hormone is derived from the smaller mRNA isoform that omits the first section of exon III?
- 5-10%
- 20-25%
- 10-15% (correct)
- 30-35%
During which condition is the release of Growth Hormone likely to increase?
During which condition is the release of Growth Hormone likely to increase?
- During high levels of hydration
- During deep sleep (correct)
- During heavy meal consumption
- During prolonged fasting
Which of the following factors does NOT influence the release of Growth Hormone?
Which of the following factors does NOT influence the release of Growth Hormone?
What is the primary site of production for Growth Hormone?
What is the primary site of production for Growth Hormone?
Flashcards
What is Growth Hormone (GH)?
What is Growth Hormone (GH)?
Growth Hormone (GH) is a 191 amino acid peptide hormone produced by the anterior pituitary gland. It plays a crucial role in regulating growth and development.
What are the isoforms of GH?
What are the isoforms of GH?
There are two isoforms of GH, both produced by alternative splicing. The most common isoform is a 191 amino acid protein with a molecular weight of 22kDa. A smaller isoform with a missing section in exon III exists in 10-15% of cases.
How is GH released?
How is GH released?
GH is released in pulsatile bursts throughout the day, with the highest levels occurring during deep sleep at night. Exercise and trauma can also stimulate GH release.
What influences GH release?
What influences GH release?
Signup and view all the flashcards
What is the normal level of GH in the blood?
What is the normal level of GH in the blood?
Signup and view all the flashcards
Study Notes
Growth Hormone (GH) Structure and Characteristics
- Growth Hormone (GH) is a 191 amino acid peptide hormone.
- Its molecular weight is approximately 22 kDa.
- GH has a similar structure to prolactin and chorionic somatomammotropin (placental hormone).
- Two isoforms of GH exist, produced by alternative splicing.
- Most GH isoforms include all 5 exons, translated into a 191 amino acid protein of 22 kDa.
- 10-15% of GH is derived from smaller mRNA molecules, omitting the first section of exon III.
Production and Release of GH
- GH is produced by somatotrophs in the anterior pituitary gland.
- GH release occurs in pulsatile bursts throughout the day.
- GH release is largely prominent during nighttime (deep sleep).
- Exercise and trauma also increase GH release.
Factors Influencing GH Release
- Nutritional status influences GH release.
- Metabolic conditions influence GH release.
- Age-related sex steroids influence GH release.
- Adrenal glucocorticoids influence GH release.
- Thyroid hormones influence GH release.
- Renal function influences GH release.
- Hepatic function influences GH release.
Circulation of GH
- Normal circulating levels of GH (specific value omitted in the provided text).
- The provided text does not describe the details of GH binding.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
This quiz covers the structure, production, and release of Growth Hormone (GH). It explores its characteristics, isoforms, and factors influencing its release. Test your knowledge on this important peptide hormone and its physiological roles.
