12 Questions
What percentage of GH circulates free in plasma?
~60%
In maximal stimulation, what changes in the GH pulsatile secretion pattern?
Frequency of pulses increases
During which stage of sleep does GH pulsatile secretion occur?
Stages III & IV
What is the main effect of GH on adipose cells?
Lipolysis
What is the main regulatory effect of somatostatin on growth hormone (GH) secretion?
Inhibits GH secretion by inhibiting the action of GHRH
What effect does GHRH have on growth hormone (GH) secretion?
Stimulates GH secretion by activating somatotrophs cells
Which hormone is responsible for mediating the growth-promoting action of growth hormone (GH)?
Insulin-like growth factor I & II (IGF-I & II)
What induces the secretory burst of growth hormone (GH) at puberty?
Estrogens and testosterone
What is the most common cause of acromegaly?
Excessive growth hormone (GH) secretion
Which condition may result from multiple anterior pituitary hormone deficiencies?
Pituitary dwarfism
What is the effect of GH deficiency in childhood if left untreated?
Pituitary dwarfism
What is the outcome of a glucose suppression test in a patient with acromegaly?
GH levels remain high after glucose ingestion
Learn about the regulation and mechanism of secretion of growth hormone, its metabolic effects, actions in the regulation of growth, and its role in the fasted state. Understand the physiological actions of growth hormone and insulin like growth factor I (IGF-I) and their pathophysiological aspects.
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