Graft-Versus-Host Rejection Quiz

It is mediated primarily by host T cells that react against alloantigens in the graft

It occurs when grafted mature T cells in the graft react with alloantigens of the host

Hyperacute rejection occurs within minutes

It occurs over months to years and leads to a progressive loss of graft function (correct)

CAR-T cells, but not TCR-T cells, need to be engineered in vitro

CAR-T cells can survive longer than TCR-T, and have the potential to live months to years in patients after infusion

Both CAR-T and TCR-T cells have to recognize tumor antigens presented by MHC-I

CAR-T cells usually target cell surface proteins, whereas TCR-T cells can also target intracellular proteins (correct)

It is resolved within a few days after transplantation

It primarily affects the graft's function within minutes of transplantation

It is mediated by the host's T cells reacting against the graft's antigens

It is mainly caused by the graft's mature T cells reacting with the host's antigens (correct)

<p>CAR-T cells recognize cell surface proteins, while TCR-T cells can target intracellular proteins</p> Signup and view all the answers

<p>The graft's T cells react with the host's antigens</p> Signup and view all the answers