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Questions and Answers
Which of the following statements about graft-versus-host rejection (GVHR) is most accurate?
Which of the following statements about graft-versus-host rejection (GVHR) is most accurate?
- It is mediated primarily by host T cells that react against alloantigens in the graft
- It occurs when grafted mature T cells in the graft react with alloantigens of the host
- Hyperacute rejection occurs within minutes
- It occurs over months to years and leads to a progressive loss of graft function (correct)
What is a correct difference between CAR-T and TCR-T cells?
What is a correct difference between CAR-T and TCR-T cells?
- CAR-T cells, but not TCR-T cells, need to be engineered in vitro
- CAR-T cells can survive longer than TCR-T, and have the potential to live months to years in patients after infusion
- Both CAR-T and TCR-T cells have to recognize tumor antigens presented by MHC-I
- CAR-T cells usually target cell surface proteins, whereas TCR-T cells can also target intracellular proteins (correct)
Which of the following is true about GVHR?
Which of the following is true about GVHR?
- It is resolved within a few days after transplantation
- It primarily affects the graft's function within minutes of transplantation
- It is mediated by the host's T cells reacting against the graft's antigens
- It is mainly caused by the graft's mature T cells reacting with the host's antigens (correct)
What distinguishes CAR-T cells from TCR-T cells?
What distinguishes CAR-T cells from TCR-T cells?
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What happens in GVHR?
What happens in GVHR?
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