GPCRs Signal Transduction Quiz

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What is the enzymatic activity of the cytosolic part of the insulin receptor?

GTPase activity

Tyrosine kinase activity (correct)

Serine/threonine kinase activity

Phosphatase activity

Which type of receptors are usually connected by a single transmembrane domain to link their ligand-binding extracellular domain with the cytosolic enzymatic domain?

Tyrosine kinase receptors (correct)

Jak-Stat receptors

Ligand-gated ion channels

GPCRs

In receptor enzymes that are kinases or bind kinases, where is the ligand-binding domain usually located?

Endoplasmic reticulum

Cytosol

Nucleus

Extracellular space (correct)

What is the primary result of auto(cross)phosphorylation of tyrosine residues in the C-termini of the insulin receptor subunits?

Enhancement of tyrosine kinase activity Signup and view all the answers

Which disease condition is associated with LH receptor malfunction?

Precocious puberty Signup and view all the answers

Where is the insulin binding site located on the insulin receptor?

Extracellular domain Signup and view all the answers

What type of receptors are found as dimers bound to HREs in the absence of ligand?

Nuclear receptors Signup and view all the answers

Which type of receptors translocate to the nucleus upon binding of the ligand?

Cytosolic receptors Signup and view all the answers

What type of receptors are complexed with inhibitor proteins like HSP family when no hormone is bound?

Cytosolic receptors Signup and view all the answers

Which type of receptors dissociate from proteins and translocate to the nucleus upon hormone binding?

Cytosolic receptors Signup and view all the answers

What type of receptors are fully synthesized inside the same cell where receptor activation occurs?

Nuclear receptors Signup and view all the answers

Which type of receptors bind HREs in the nucleus upon ligand activation?

Nuclear receptors Signup and view all the answers

What type of receptors are insulin receptors?

Receptor enzymes Signup and view all the answers

Which of the following is NOT a second messenger involved in signal transduction?

Insulin Signup and view all the answers

What is the characteristic feature of the intracellular receptors for lipid-soluble hormones?

They are transcription activators Signup and view all the answers

Which molecules initiate the expression of growth-promoting genes in response to Epidermal Growth Factor (EGF) signaling?

Hormone response elements (HRE) Signup and view all the answers

Which category of signaling mechanisms involves receptors that activate enzymes through G-proteins?

Receptor enzymes that are Kinases or bind Kinases Signup and view all the answers

GPCRs Signal Transduction Quiz

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Questions and Answers

What is the enzymatic activity of the cytosolic part of the insulin receptor?

Which type of receptors are usually connected by a single transmembrane domain to link their ligand-binding extracellular domain with the cytosolic enzymatic domain?

In receptor enzymes that are kinases or bind kinases, where is the ligand-binding domain usually located?

What is the primary result of auto(cross)phosphorylation of tyrosine residues in the C-termini of the insulin receptor subunits?

Which disease condition is associated with LH receptor malfunction?

Where is the insulin binding site located on the insulin receptor?

What type of receptors are found as dimers bound to HREs in the absence of ligand?

Which type of receptors translocate to the nucleus upon binding of the ligand?

What type of receptors are complexed with inhibitor proteins like HSP family when no hormone is bound?

Which type of receptors dissociate from proteins and translocate to the nucleus upon hormone binding?

What type of receptors are fully synthesized inside the same cell where receptor activation occurs?

Which type of receptors bind HREs in the nucleus upon ligand activation?

What type of receptors are insulin receptors?

Which of the following is NOT a second messenger involved in signal transduction?

What is the characteristic feature of the intracellular receptors for lipid-soluble hormones?

Which molecules initiate the expression of growth-promoting genes in response to Epidermal Growth Factor (EGF) signaling?

Which category of signaling mechanisms involves receptors that activate enzymes through G-proteins?

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