GPCRs Signal Transduction Quiz
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Questions and Answers

What is the enzymatic activity of the cytosolic part of the insulin receptor?

  • GTPase activity
  • Tyrosine kinase activity (correct)
  • Serine/threonine kinase activity
  • Phosphatase activity

Which type of receptors are usually connected by a single transmembrane domain to link their ligand-binding extracellular domain with the cytosolic enzymatic domain?

  • Tyrosine kinase receptors (correct)
  • Jak-Stat receptors
  • Ligand-gated ion channels
  • GPCRs

In receptor enzymes that are kinases or bind kinases, where is the ligand-binding domain usually located?

  • Endoplasmic reticulum
  • Cytosol
  • Nucleus
  • Extracellular space (correct)

What is the primary result of auto(cross)phosphorylation of tyrosine residues in the C-termini of the insulin receptor subunits?

<p>Enhancement of tyrosine kinase activity (A)</p> Signup and view all the answers

Which disease condition is associated with LH receptor malfunction?

<p>Precocious puberty (D)</p> Signup and view all the answers

Where is the insulin binding site located on the insulin receptor?

<p>Extracellular domain (D)</p> Signup and view all the answers

What type of receptors are found as dimers bound to HREs in the absence of ligand?

<p>Nuclear receptors (C)</p> Signup and view all the answers

Which type of receptors translocate to the nucleus upon binding of the ligand?

<p>Cytosolic receptors (D)</p> Signup and view all the answers

What type of receptors are complexed with inhibitor proteins like HSP family when no hormone is bound?

<p>Cytosolic receptors (A)</p> Signup and view all the answers

Which type of receptors dissociate from proteins and translocate to the nucleus upon hormone binding?

<p>Cytosolic receptors (C)</p> Signup and view all the answers

What type of receptors are fully synthesized inside the same cell where receptor activation occurs?

<p>Nuclear receptors (D)</p> Signup and view all the answers

Which type of receptors bind HREs in the nucleus upon ligand activation?

<p>Nuclear receptors (A)</p> Signup and view all the answers

What type of receptors are insulin receptors?

<p>Receptor enzymes (B)</p> Signup and view all the answers

Which of the following is NOT a second messenger involved in signal transduction?

<p>Insulin (D)</p> Signup and view all the answers

What is the characteristic feature of the intracellular receptors for lipid-soluble hormones?

<p>They are transcription activators (B)</p> Signup and view all the answers

Which molecules initiate the expression of growth-promoting genes in response to Epidermal Growth Factor (EGF) signaling?

<p>Hormone response elements (HRE) (C)</p> Signup and view all the answers

Which category of signaling mechanisms involves receptors that activate enzymes through G-proteins?

<p>Receptor enzymes that are Kinases or bind Kinases (C)</p> Signup and view all the answers

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