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Questions and Answers
What is the enzymatic activity of the cytosolic part of the insulin receptor?
What is the enzymatic activity of the cytosolic part of the insulin receptor?
- GTPase activity
- Tyrosine kinase activity (correct)
- Serine/threonine kinase activity
- Phosphatase activity
Which type of receptors are usually connected by a single transmembrane domain to link their ligand-binding extracellular domain with the cytosolic enzymatic domain?
Which type of receptors are usually connected by a single transmembrane domain to link their ligand-binding extracellular domain with the cytosolic enzymatic domain?
- Tyrosine kinase receptors (correct)
- Jak-Stat receptors
- Ligand-gated ion channels
- GPCRs
In receptor enzymes that are kinases or bind kinases, where is the ligand-binding domain usually located?
In receptor enzymes that are kinases or bind kinases, where is the ligand-binding domain usually located?
- Endoplasmic reticulum
- Cytosol
- Nucleus
- Extracellular space (correct)
What is the primary result of auto(cross)phosphorylation of tyrosine residues in the C-termini of the insulin receptor subunits?
What is the primary result of auto(cross)phosphorylation of tyrosine residues in the C-termini of the insulin receptor subunits?
Which disease condition is associated with LH receptor malfunction?
Which disease condition is associated with LH receptor malfunction?
Where is the insulin binding site located on the insulin receptor?
Where is the insulin binding site located on the insulin receptor?
What type of receptors are found as dimers bound to HREs in the absence of ligand?
What type of receptors are found as dimers bound to HREs in the absence of ligand?
Which type of receptors translocate to the nucleus upon binding of the ligand?
Which type of receptors translocate to the nucleus upon binding of the ligand?
What type of receptors are complexed with inhibitor proteins like HSP family when no hormone is bound?
What type of receptors are complexed with inhibitor proteins like HSP family when no hormone is bound?
Which type of receptors dissociate from proteins and translocate to the nucleus upon hormone binding?
Which type of receptors dissociate from proteins and translocate to the nucleus upon hormone binding?
What type of receptors are fully synthesized inside the same cell where receptor activation occurs?
What type of receptors are fully synthesized inside the same cell where receptor activation occurs?
Which type of receptors bind HREs in the nucleus upon ligand activation?
Which type of receptors bind HREs in the nucleus upon ligand activation?
What type of receptors are insulin receptors?
What type of receptors are insulin receptors?
Which of the following is NOT a second messenger involved in signal transduction?
Which of the following is NOT a second messenger involved in signal transduction?
What is the characteristic feature of the intracellular receptors for lipid-soluble hormones?
What is the characteristic feature of the intracellular receptors for lipid-soluble hormones?
Which molecules initiate the expression of growth-promoting genes in response to Epidermal Growth Factor (EGF) signaling?
Which molecules initiate the expression of growth-promoting genes in response to Epidermal Growth Factor (EGF) signaling?
Which category of signaling mechanisms involves receptors that activate enzymes through G-proteins?
Which category of signaling mechanisms involves receptors that activate enzymes through G-proteins?
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