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Gout: Disease of Kings

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Questions and Answers

What happens to the polymorphonuclear cells when monosodium urate crystals are increased in number?

They engulf the crystals and their plasma membrane is disrupted, releasing cytokines and chemokines. (correct)

They release cytokines and chemokines that reduce inflammation and swelling.

They multiply rapidly to combat the increasing number of crystals.

They die immediately, causing the inflammation and swelling to cease.

What is the typical duration of an acute gout attack?

Several years to a decade

A few weeks to a few months

Several days to a week (correct)

A few months to a year

What is the most common feature of gout?

Nodule appearance in the skin of affected joints

Edema in and around the affected joint

Permanent joint stiffness, damage, and deformity

Inflammation, swelling, and severe pain in the affected joints and skin around (correct)

What is the likely outcome of untreated chronic gout?

Permanent joint stiffness, damage, and deformity Signup and view all the answers

What is the most affected joint in gout?

Big toe (monarticular) Signup and view all the answers

What happens to the joints over time if gout is left untreated?

They become more affected, especially the ankles, knees, fingers, wrists, and elbows (polyarticular) Signup and view all the answers

What is characteristic of chronic gout?

Short breaks in between attacks Signup and view all the answers

What is a common feature of gout in addition to inflammation and swelling?

Edema in and around the affected joint Signup and view all the answers

What is the difference between acute and chronic gout?

The frequency and duration of attacks Signup and view all the answers

What is the result of the release of cytokines and chemokines in gout?

Increased inflammation and swelling Signup and view all the answers