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Questions and Answers
Which type of hormone cannot pass through the cell membrane?
Which type of hormone cannot pass through the cell membrane?
How do steroid hormones reach target cells?
How do steroid hormones reach target cells?
Which of the following is a function of hormones?
Which of the following is a function of hormones?
What role does the hypothalamus play in the endocrine system?
What role does the hypothalamus play in the endocrine system?
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Which hormone showcases a quick onset time due to its peptide nature?
Which hormone showcases a quick onset time due to its peptide nature?
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Which statement about nerve signals is true?
Which statement about nerve signals is true?
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What distinguishes tropic hormones from others?
What distinguishes tropic hormones from others?
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Which gland is primarily responsible for the secretion of thyroid-stimulating hormone (TSH)?
Which gland is primarily responsible for the secretion of thyroid-stimulating hormone (TSH)?
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Hormones secreted by the endocrine glands travel directly into what?
Hormones secreted by the endocrine glands travel directly into what?
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What is a common characteristic of peptide hormones?
What is a common characteristic of peptide hormones?
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Which organ does not have cells with an endocrine function?
Which organ does not have cells with an endocrine function?
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Which substance accumulates in areas of tissue disturbance or injury?
Which substance accumulates in areas of tissue disturbance or injury?
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When a hormone binds to a receptor, which of the following does NOT occur?
When a hormone binds to a receptor, which of the following does NOT occur?
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What happens when an amino-acid-based hormone acts on a target cell?
What happens when an amino-acid-based hormone acts on a target cell?
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If cyclic AMP acts as a 'second messenger,' what would be the 'first messenger'?
If cyclic AMP acts as a 'second messenger,' what would be the 'first messenger'?
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Which is an example of an amino-acid-based hormone?
Which is an example of an amino-acid-based hormone?
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Which of the following statements is TRUE regarding amino-acid-based hormones?
Which of the following statements is TRUE regarding amino-acid-based hormones?
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What characteristic of steroid hormones allows them to pass through cell membranes?
What characteristic of steroid hormones allows them to pass through cell membranes?
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Which organ is responsible for removing hormones from the blood and breaking them down?
Which organ is responsible for removing hormones from the blood and breaking them down?
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Why is the pituitary gland no longer considered the 'master gland' of the endocrine system?
Why is the pituitary gland no longer considered the 'master gland' of the endocrine system?
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Study Notes
Endocrine System
- The endocrine system is made up of glands that secrete hormones directly into the blood.
Hormones
- Hormones are chemical substances secreted directly into the blood by ductless glands.
- They can be classified into two groups:
- Peptide Hormones: Formed from proteins, have a quick onset time, cannot pass cell membrane, and are hydrophilic. Examples include insulin and growth hormone.
- Steroid Hormones: Formed from fats, can enter the cell membrane, are hydrophilic, and have a slower onset than peptide hormones. Examples include estrogen, progesterone, and testosterone.
Tropic Hormones
- Tropic hormones are hormones that stimulate other glands to release hormones.
- They have a far-reaching effect because they can trigger a cascade of hormonal release.
- Example: The anterior pituitary releases thyroid-stimulating hormone (TSH), which then stimulates the thyroid gland to produce thyroxine.
Hypothalamus
- The hypothalamus acts as a bridge between the endocrine and nervous systems.
- It functions both as part of the nervous system and as an endocrine gland:
- Nervous System Function: During stress, the hypothalamus sends electrical signals to the adrenal gland to release adrenaline.
- Endocrine Gland Function: It produces oxytocin and antidiuretic hormone, which are stored in the posterior pituitary.
- Regulatory Function: The hypothalamus also regulates temperature, hunger, thirst, and coughing.
Pituitary Gland
- The pituitary gland releases several hormones, including FSH and LH.
Functions of Hormones
- Hormones control the body's response to stress.
- They regulate metabolism and growth and development.
- Hormones do not trigger rapid, short-term responses; this function is carried out by the nervous system.
Hormone Action
- For a hormone to work, it must reach its target cells, be produced and released, and enter the bloodstream or fluids around cells.
- Hormones do not travel through ducts.
- Hormones bind to receptor proteins on the surface of target cells, triggering a cascade of events that ultimately lead to the desired change in cell function.
Nervous System vs. Endocrine System
- Nervous signals are much faster than hormonal messages but have shorter-lasting effects.
- Nerve transmissions reach many cells at once, while hormonal messages can be more targeted.
Endocrine Glands
- All endocrine glands secrete hormones directly into the bloodstream or the fluid around cells.
- Not all hormones affect every cell near the gland.
- Hormones are not always lipid molecules.
Organs with Endocrine Function
- The brain, stomach, small intestine, and lungs all contain cells that have an endocrine function.
Prostaglandins
- Prostaglandins are hormone-like substances that accumulate in areas of tissue disturbance or injury.
Hormone Binding
- When a hormone binds to a receptor, the receptor protein changes shape, which then triggers a series of chemical reactions inside the cell, ultimately leading to a change in cell activity.
- Hormones do not enter the cell by endocytosis.
Amino-Acid-Based Hormones
- Amino-acid-based hormones bind to receptors in the cell membrane, triggering the activation of a second messenger like cyclic AMP.
- They do not pass through the cell membrane; they activate a chain reaction to cause a change inside the cell.
Steroid Hormones
- Steroid hormones are fat-soluble and can pass through the cell membranes of their target cells.
- They are not always bound to fat receptor molecules.
- They can influence gene expression in target cells.
Hormone Regulation
- The liver plays a role in feedback by removing hormones from the blood and breaking them down.
Anterior Pituitary Gland
- The anterior pituitary gland secretes several tropins, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid-stimulating hormone (TSH).
- It does not produce antidiuretic hormone (ADH).
Pituitary Gland Regulation
- Hormones produced by the pituitary gland are regulated by secretions from the hypothalamus.
- They control the activity of other endocrine glands and affect many organs and tissues.
- The pituitary gland does not primarily regulate metabolic rate; this is primarily regulated by the thyroid gland.
Hypothalamus-Pituitary Relationship
- The hypothalamus acts as the regulatory center of the endocrine system, controlling the activity of the pituitary gland.
- It does not control other glands by acting through the pituitary gland; instead, it directly controls other glands or indirectly through the pituitary.
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