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Questions and Answers

What is the most significant laboratory finding expected in this patient with severe diarrhea?

  • Increased serum Na+ concentration (correct)
  • Increased serum HCO3- concentration
  • Decreased serum K+ concentration
  • Decreased serum Ca2+ concentration

Which study is most appropriate to evaluate the cause of the patient's diarrhea?

  • Stool specimen to identify Cryptosporidium (correct)
  • Duodenal biopsy to identify Entamoeba histolytica
  • Culture of the oral cavity for Candida albicans
  • Colonic biopsy to identify Giardia lamblia

What does the low ratio of helper T lymphocytes to suppressor T lymphocytes indicate in this patient with HIV?

  • Induces proliferation of suppressor T lymphocytes
  • Infects cells with CD4 receptors (correct)
  • Infects macrophages
  • Induces proliferation of helper T lymphocytes

Which of the following organisms is most commonly associated with severe watery diarrhea in patients with weakened immune systems?

<p>Cryptosporidium (B)</p> Signup and view all the answers

What is a common cause of increased serum sodium concentration in patients experiencing severe dehydration?

<p>Insufficient fluid intake (D)</p> Signup and view all the answers

Which condition is most likely to result in a significant muscle weakness in a patient with diarrhea and dehydration?

<p>Hypokalemia (B)</p> Signup and view all the answers

What role do CD4 receptor cells play in the pathophysiology of HIV infection?

<p>They serve as primary target cells for HIV infection. (B)</p> Signup and view all the answers

What factor is most important when considering the laboratory testing approach for a patient with diarrhea related to HIV infection?

<p>Underlying immune status (B)</p> Signup and view all the answers

Which finding is most indicative of a diagnosis of autoimmune disease rather than infectious disease?

<p>Positive rheumatoid factor (D)</p> Signup and view all the answers

A patient is experiencing fatigue and jaundice. Exposure to which toxic agent is most likely causing these symptoms?

<p>Carbon tetrachloride (D)</p> Signup and view all the answers

Which dietary condition is most likely to occur in a patient following a strict vegan diet?

<p>Vitamin B12 deficiency (C)</p> Signup and view all the answers

Which of the following is the most likely mechanism of therapeutic effect for statins in patients with hyperlipidemia?

<p>Inhibition of HMG-CoA reductase (B)</p> Signup and view all the answers

Which of the following lab findings would be most expected in a patient diagnosed with type 1 diabetes mellitus?

<p>High HbA1c levels (B)</p> Signup and view all the answers

A patient has clear signs of heart failure. Which of the following abnormal findings is most likely to be present?

<p>Increased jugular venous pressure (C)</p> Signup and view all the answers

Which of the following findings is most strongly associated with a diagnosis of Cushing's syndrome?

<p>Moon facies and abdominal striae (A)</p> Signup and view all the answers

What is the most likely cause of elevated alkaline phosphatase levels in a patient with bone pain?

<p>Bone turnover or disease (A)</p> Signup and view all the answers

A 60-year-old woman presents with symptoms of fatigue and weakness, leading to a suspicion of a metabolic disorder. Which of the following biosynthetic pathways is likely defected if she is deficient in heme production?

<p>Heme biosynthesis (C)</p> Signup and view all the answers

A 55-year-old man with hyperthyroidism presents with symptoms of palpitations and weight loss. Which hormone's production might be affected if there is an issue in the thyroxine synthesis pathway?

<p>Thyroxine (T4) (C)</p> Signup and view all the answers

A 70-year-old woman experiences joint pain and skin rashes. If a defect in collagen synthesis is suspected, which dietary compound might be crucial for her recovery?

<p>Vitamin C (C)</p> Signup and view all the answers

A 40-year-old man visits the emergency department with abdominal pain and jaundice. Which condition might be indicated by a disruption in the steroid biosynthesis pathway?

<p>Adrenal insufficiency (D)</p> Signup and view all the answers

A 50-year-old woman has difficulty metabolizing fat and experiences fatigue. What type of biosynthetic pathway is likely impaired?

<p>Fatty acid synthesis (D)</p> Signup and view all the answers

A 30-year-old male presents with symptoms of lethargy and hair loss. Which condition might result from a defect in the heme synthesis pathway?

<p>Iron deficiency anemia (A)</p> Signup and view all the answers

A 65-year-old man presents with signs of growth retardation and poor muscle development. Which of the following biosynthetic pathways might be disrupted?

<p>Collagen synthesis (D)</p> Signup and view all the answers

A 48-year-old woman presents with abnormal weight gain and mood changes. If she is on medications affecting corticosteroid production, which biosynthetic pathway needs to be evaluated?

<p>Corticosteroid synthesis (B)</p> Signup and view all the answers

Flashcards

Identifying a drug cause

Determining the medication most likely responsible for a patient's symptoms or findings.

Diagnosis differentiation

Determining the most likely diagnosis by distinguishing it from another potential diagnosis based on additional findings.

Mechanism of disease

Identifying the absence or presence of a specific enzyme or process causing a particular disease in a patient.

Predicting dietary consequences

Determining the likely health impact of a particular dietary regime.

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Drug response prediction

Identifying how a drug or class of drugs will likely affect a patient with a specific condition.

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Predicting post-event findings

Anticipating lab results or symptoms that might develop after a specific event or exposure (like a trip or food ingestion).

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Infectious agent identification

Identifying the pathogen causing an illness by analyzing the suspected source (e.g., food).

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Cause and effect analysis (disease)

Determining the most likely reason for a patient's death or illness by considering available facts and findings.

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Heme Synthesis Defect

A problem in the body's process of making heme, a molecule essential for red blood cells and carrying oxygen.

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Collagen Synthesis Defect

Issues in the production of collagen, a protein that provides structure and support to tissues like skin, bones, and tendons.

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Thyroxine Synthesis Defect

A disruption in the production of thyroxine (T4), a hormone crucial for metabolism and growth.

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Corticosteroid Synthesis Defect

Issues with the body's ability to make corticosteroids, hormones that regulate inflammation, immune function, and blood sugar.

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Fatty Acid Synthesis Defect

A problem in the process of making fatty acids, essential components of cell membranes and energy storage.

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Glucose Synthesis Defect

A disruption in the body's ability to make glucose, the primary source of energy for most cells.

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Patient Description

Information about the patient, including age, gender, location of care, and presenting complaint.

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Patient History

Information about the patient's past medical experiences, including family history and existing conditions.

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Watery diarrhea cause

Identifying the most likely cause of severe watery diarrhea in a 34-year-old woman with a history of infectious mononucleosis and intravenous drug abuse.

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Low potassium levels

Hypokalaemia, or low potassium levels in the blood, is a common finding in patients with severe watery diarrhea.

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HIV and T cell ratio

The ratio of helper T cells to suppressor T cells is a key indicator of HIV infection status and disease progression.

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HIV's effect on T cells

HIV primarily infects and destroys cells with CD4 receptors, which are primarily found on helper T cells.

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Cryptosporidium infection

Cryptosporidium is a common intestinal parasite that can cause severe diarrhea, particularly in immunocompromised individuals.

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Cueing in PBL

Providing hints about answers to later questions in earlier questions during Problem Based Learning (PBL).

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Hinging in PBL

A technique in PBL where a later question builds on the answer to a previous question, creating a logical flow of learning.

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Avoiding Cueing in PBL

It's crucial to avoid providing hints or clues in later questions that reveal answers to earlier questions in PBL.

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Study Notes

Book Title and Edition

  • Constructing Written Test Questions
  • Third Edition

Authors

  • Susan M. Case
  • David B. Swanson

Publisher and Address

  • National Board of Medical Examiners
  • 3750 Market Street
  • Philadelphia, PA 19104
  • Copyright information includes years, and the National Board of Medical Examiners is the copyright holder.
  • Permission is granted for non-commercial, educational, and scientific use, but the copyright and permission notices must appear on all reproductions.
  • The document cannot be modified in any way.

Table of Contents

  • The book covers various sections regarding constructing written test questions in the basic and clinical sciences, including sections on item formats, item content, technical item flaws, testwiseness, irrelevant difficulty, and more.
  • The book contains chapters on different test question formats, including true/false, multiple-choice, and extended-matching items.
  • The book includes practical aspects and advice on writing test items.
  • The book includes practical templates for creating questions.
  • Included are general guidelines on item construction.

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