Glyoxylate Cycle and Fatty Acid Catabolism Quiz
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Questions and Answers

Which regulatory enzyme is inhibited by succinyl-CoA via feedback inhibition?

  • Citrate synthase (correct)
  • α-ketoglutarate dehydrogenase
  • Pyruvate dehydrogenase
  • Isocitrate dehydrogenase

What effect does high levels of ATP have on the Pyruvate Dehydrogenase Complex?

  • It converts acetyl-CoA to pyruvate
  • It phosphorylates E1 and inactivates the enzyme complex (correct)
  • It activates the enzyme complex
  • It promotes substrate channeling

Which molecule activates most of the regulated enzymes in the Citric Acid Cycle?

  • ATP
  • Succinyl-CoA
  • ADP (correct)
  • Acetyl-CoA

What is the purpose of the Glyoxylate Cycle in plants and microorganisms?

<p>To replenish citric acid cycle intermediates (B)</p> Signup and view all the answers

In fatty acid catabolism, what happens when H+ is added to the carbanion intermediate formed by treating fumarate with OH-?

<p>Formation of L-malate (B)</p> Signup and view all the answers

Which enzyme catalyzes the oxidation of L-malate to oxaloacetate?

<p>Malate dehydrogenase (C)</p> Signup and view all the answers

How is the Pyruvate Dehydrogenase Complex regulated when ATP levels are low?

<p>[ADP] increases and activates PDH phosphorylase to reactivate the complex (B)</p> Signup and view all the answers

What is the key product generated when L-malate is oxidized to oxaloacetate?

<p>NADH (C)</p> Signup and view all the answers

Which molecule carries CO2 between enzyme active sites in the citric acid cycle?

<p>[Biotin] (A)</p> Signup and view all the answers

How do activated bicarbonate and biotin interact during the citric acid cycle?

<p>Activated bicarbonate reacts with [Biotin] (A)</p> Signup and view all the answers

What is the primary purpose of the Glyoxylate Cycle in terms of energy production?

<p>To convert acetyl-CoA to oxaloacetate for glucose production (C)</p> Signup and view all the answers

Which enzyme bypasses decarboxylation reactions in the citric acid cycle during the Glyoxylate Cycle?

<p>Isocitrate lyase (B)</p> Signup and view all the answers

What is the fate of acetyl-CoA in animals, according to the text?

<p>Converted to glucose via gluconeogenesis (B)</p> Signup and view all the answers

Which of the following is NOT a function of fatty acids in energy storage, as mentioned in the text?

<p>High solubility in blood for easy transport (D)</p> Signup and view all the answers

What triggers the mobilization of stored triacylglycerols from adipocytes?

<p>Binding of glucagon or epinephrine to their cellular receptor(s) (C)</p> Signup and view all the answers

Which molecule is used as a molecular carrier of fatty acids into the mitochondrial matrix?

<p>Carnitine (B)</p> Signup and view all the answers

What is the role of thiolase in fatty acid oxidation?

<p>Transfer of the fatty acid chain by catalyzing thiolysis reactions (A)</p> Signup and view all the answers

In fatty acid oxidation, what is the function of enoyl-CoA hydratase?

<p>Hydration of an alkene to form an alcohol product (A)</p> Signup and view all the answers

What is the primary role of Acyl-CoA dehydrogenase in fatty acid catabolism?

<p>Dehydrogenation of an alkane to an alkene (B)</p> Signup and view all the answers

What is the stereospecificity observed during hydration in the fatty acid catabolic pathway?

<p>Formation of only L-isomers (A)</p> Signup and view all the answers

What is the primary role of Coenzyme A-SH (CoA-SH) in fatty acid catabolism?

<p>Transfer of acetyl groups for further oxidation (C)</p> Signup and view all the answers

Which intermediate is formed from odd-numbered fatty acids during β-oxidation?

<p>Propionyl-CoA (B)</p> Signup and view all the answers

What is the fate of acetyl-CoA produced from fatty acid oxidation?

<p>Enters the citric acid cycle for further oxidation (B)</p> Signup and view all the answers

Which enzyme is involved in the conversion of propionyl-CoA to succinyl-CoA?

<p>Methylmalonyl-CoA Mutase (C)</p> Signup and view all the answers

What additional steps are required for the oxidation of unsaturated fatty acids?

<p>Isomerization and reduction of double bonds (D)</p> Signup and view all the answers

Which process occurs when oxaloacetate is depleted during prolonged fasting or diabetes?

<p>Ketone body formation from acetyl-CoA (A)</p> Signup and view all the answers

In the electron transport chain, which molecule transports electrons from Complexes I and II to Complex III?

<p>Coenzyme Q (CoQ/CoQH2) (B)</p> Signup and view all the answers

What is the function of Cytochromes in the electron transport chain?

<p>To carry electrons and exist in Fe3+ or Fe2+ forms (C)</p> Signup and view all the answers

Which amino acid catabolism product can be converted into glucose or glycogen?

<p>Pyruvate (D)</p> Signup and view all the answers

What is the role of Iron-sulfur clusters in the electron transport chain?

<p>To carry electrons through protein complexes in various arrangements (B)</p> Signup and view all the answers
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