Glycosylphosphatidylinositol-Anchored Protein Remodelase Cdc1p Quiz
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Questions and Answers

Where is Cdc1p localized?

  • Cis/medial Golgi membrane (correct)
  • Endoplasmic reticulum (ER)
  • Mitochondria
  • Nucleus

What happens when ER-localized Cdc1p-HDEL is expressed at endogenous levels?

  • It is unable to support the growth of cells (correct)
  • It supports the growth of cells
  • It causes the cells to become resistant to EtNP removal
  • It leads to increased phosphoethanolamine (EtNP) addition to GPI-APs

What is the cycling pattern of Cdc1p between the Golgi and the ER?

  • It remains solely in the Golgi
  • It moves from the ER to the Golgi but does not return (correct)
  • It cycles continuously between the Golgi and the ER
  • It is transported from the Golgi to the ER

What is the role of Cdc1p in the remodeling of GPI-APs?

<p>Removal of EtNP from Man1 (C)</p> Signup and view all the answers

What are the posttranslational modifications and remodeling processes that glycosylphosphatidylinositol-anchored proteins (GPI-APs) undergo?

<p>GPI-APs undergo extensive posttranslational modifications and remodeling, including the addition and subsequent removal of phosphoethanolamine (EtNP) from mannose 1 (Man1) and mannose 2 (Man2) of the glycan moiety.</p> Signup and view all the answers

What is the catalytic role of Cdc1p in the remodeling of GPI-APs?

<p>Cdc1p catalyzes the removal of phosphoethanolamine (EtNP) from mannose 1 (Man1) of the glycan moiety of GPI-APs.</p> Signup and view all the answers

What is the role of COPI coatomer in relation to Cdc1p?

<p>It assists in the retention of Cdc1p in the Golgi (C)</p> Signup and view all the answers

What is the reliance of Cdc1p on in order to be retained in the Golgi organelle?

<p>Cdc1p relies on the COPI coatomer for its retention in the Golgi organelle.</p> Signup and view all the answers

What is the actual localization of Cdc1p within the cell?

<p>Cdc1p is a cis/medial Golgi membrane protein.</p> Signup and view all the answers

What is the cycling pattern of Cdc1p between the Golgi and the ER?

<p>Cdc1p does not cycle between the Golgi and the ER, and when expressed at endogenous levels, ER-localized Cdc1p-HDEL is unable to support growth.</p> Signup and view all the answers
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