10 Questions
Where is Cdc1p localized?
Cis/medial Golgi membrane
What happens when ER-localized Cdc1p-HDEL is expressed at endogenous levels?
It is unable to support the growth of cells
What is the cycling pattern of Cdc1p between the Golgi and the ER?
It moves from the ER to the Golgi but does not return
What is the role of Cdc1p in the remodeling of GPI-APs?
Removal of EtNP from Man1
What are the posttranslational modifications and remodeling processes that glycosylphosphatidylinositol-anchored proteins (GPI-APs) undergo?
GPI-APs undergo extensive posttranslational modifications and remodeling, including the addition and subsequent removal of phosphoethanolamine (EtNP) from mannose 1 (Man1) and mannose 2 (Man2) of the glycan moiety.
What is the catalytic role of Cdc1p in the remodeling of GPI-APs?
Cdc1p catalyzes the removal of phosphoethanolamine (EtNP) from mannose 1 (Man1) of the glycan moiety of GPI-APs.
What is the role of COPI coatomer in relation to Cdc1p?
It assists in the retention of Cdc1p in the Golgi
What is the reliance of Cdc1p on in order to be retained in the Golgi organelle?
Cdc1p relies on the COPI coatomer for its retention in the Golgi organelle.
What is the actual localization of Cdc1p within the cell?
Cdc1p is a cis/medial Golgi membrane protein.
What is the cycling pattern of Cdc1p between the Golgi and the ER?
Cdc1p does not cycle between the Golgi and the ER, and when expressed at endogenous levels, ER-localized Cdc1p-HDEL is unable to support growth.
Test your knowledge on the localization and function of glycosylphosphatidylinositol-anchored protein remodelase Cdc1p with this quiz. Explore the molecular mechanisms and cellular processes related to the Golgi-localized protein.
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