Glycopyrrolate Flashcards
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Questions and Answers

What is the classification of glycopyrrolate?

Anticholinergic

How is glycopyrrolate supplied?

0.2mg/mL in 1mL, 2mL, 5mL and 20mL vials

What are 2 actions of glycopyrrolate?

  1. Inhibit ACh muscarinic actions on autonomic effectors innervated by post ganglionic cholinergic nerves; 2. Block cardiac vagal reflexes by blocking vagal inhibition at the SA node

What are 2 indications for glycopyrrolate?

<ol> <li>Block cholinergic effects of anticholinesterases used to reverse neuromuscular blockade; 2. In preop to diminish secretions and cardiac vagal reflexes</li> </ol> Signup and view all the answers

What is the dose of glycopyrrolate to block cholinergic effects?

<p>0.2mg IV for each 1mg of neostigmine IV/IO</p> Signup and view all the answers

What is the adult dose of glycopyrrolate for pre-op?

<p>0.0044mg/kg IM 30-60min pre-op</p> Signup and view all the answers

What are 5 contraindications of glycopyrrolate?

<ol> <li>Hypersensitivity; 2. Glaucoma; 3. Obstructive uropathy/Obstructive GI; 4. Myasthenia gravis; 5. Unstable cardiovascular system in acute hemorrhage</li> </ol> Signup and view all the answers

What are 3 precautions for glycopyrrolate?

<ol> <li>CAD, arrhythmias, heart failure; 2. Hypertension; 3. Hepatic and renal disease</li> </ol> Signup and view all the answers

What is the trade name for glycopyrrolate?

<p>Robinul</p> Signup and view all the answers

Study Notes

Glycopyrrolate Overview

  • Glycopyrrolate is classified as an anticholinergic medication.
  • Commonly supplied in concentrations of 0.2 mg/mL, available in vial sizes of 1mL, 2mL, 5mL, and 20mL.

Actions of Glycopyrrolate

  • Inhibits acetylcholine's muscarinic effects on autonomic system targets innervated by post-ganglionic cholinergic nerves.
  • Blocks cardiac vagal reflexes by preventing vagal inhibition at the sinoatrial (SA) node.

Indications

  • Used to counteract cholinergic side effects caused by anticholinesterases in neuromuscular blockade reversal.
  • Administered preoperatively to reduce secretions and manage cardiac vagal reflexes.

Dosing Information

  • For blocking cholinergic effects, the recommended dose is 0.2 mg IV per 1 mg of neostigmine administered IV/IO.
  • Adult preoperative dosage is 0.0044 mg/kg intramuscularly, typically given 30-60 minutes prior to surgery.

Contraindications

  • Not to be used in patients with hypersensitivity to the drug.
  • Contraindicated in individuals with glaucoma, obstructive uropathy, obstructive gastrointestinal conditions, myasthenia gravis, and those with unstable cardiovascular status during acute hemorrhage.

Precautions

  • Use with caution in patients with coronary artery disease (CAD), arrhythmias, and heart failure.
  • Monitor blood pressure in patients with hypertension.
  • Caution is warranted in patients with hepatic and renal diseases.

Trade Name

  • Glycopyrrolate is commercially known as Robinul.

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Test your knowledge about glycopyrrolate with these flashcards. Learn its classification, how it is supplied, and its actions in the body. Perfect for medical students or professionals reviewing pharmacological concepts.

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