Podcast
Questions and Answers
What percentage of a glycoprotein's weight is typically comprised of oligosaccharides?
What percentage of a glycoprotein's weight is typically comprised of oligosaccharides?
Which amino acid is involved in N-Linked glycosylation?
Which amino acid is involved in N-Linked glycosylation?
In which organelle does O-Linked glycosylation take place?
In which organelle does O-Linked glycosylation take place?
What is the role of dolichol phosphate in N-Linked glycosylation?
What is the role of dolichol phosphate in N-Linked glycosylation?
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What can result from dysfunction in lysosomal targeting of glycoproteins?
What can result from dysfunction in lysosomal targeting of glycoproteins?
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Which of the following structures are glycosaminoglycans (GAGs) primarily known for?
Which of the following structures are glycosaminoglycans (GAGs) primarily known for?
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What type of linkages does O-Linked glycosylation involve?
What type of linkages does O-Linked glycosylation involve?
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Which of the following best describes the basic structure of glycosaminoglycans (GAGs)?
Which of the following best describes the basic structure of glycosaminoglycans (GAGs)?
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What is the primary function of glycoproteins?
What is the primary function of glycoproteins?
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Which amino acid is notably involved in N-Linked glycosylation?
Which amino acid is notably involved in N-Linked glycosylation?
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What triggers the endocytosis of glycoproteins into lysosomes?
What triggers the endocytosis of glycoproteins into lysosomes?
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What role do lysosomal glycosidases play in glycoprotein degradation?
What role do lysosomal glycosidases play in glycoprotein degradation?
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Which of the following is a characteristic of glycosaminoglycans?
Which of the following is a characteristic of glycosaminoglycans?
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What is a common function of proteoglycans in connective tissue?
What is a common function of proteoglycans in connective tissue?
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What is a consequence of lysosomal hydrolase deficiencies?
What is a consequence of lysosomal hydrolase deficiencies?
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In Hurler syndrome, what is primarily accumulated in the body due to the disorder?
In Hurler syndrome, what is primarily accumulated in the body due to the disorder?
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Which enzyme deficiency is associated with Inclusion-cell disease (I-cell disease)?
Which enzyme deficiency is associated with Inclusion-cell disease (I-cell disease)?
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What is the first sugar removed during glycosaminoglycan degradation?
What is the first sugar removed during glycosaminoglycan degradation?
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Which characteristic describes Hyaluronan, a type of glycosaminoglycan?
Which characteristic describes Hyaluronan, a type of glycosaminoglycan?
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What effect do lysosomal storage diseases have on the nervous system?
What effect do lysosomal storage diseases have on the nervous system?
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What is the first step in the assembly of glycosaminoglycans on proteins?
What is the first step in the assembly of glycosaminoglycans on proteins?
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What is a common symptom of I-cell disease?
What is a common symptom of I-cell disease?
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Which class of biogenic amines includes compounds like serotonin and tryptamine?
Which class of biogenic amines includes compounds like serotonin and tryptamine?
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What is the rate limiting step in catecholamine synthesis?
What is the rate limiting step in catecholamine synthesis?
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Which cofactor is essential for the enzyme tyrosine hydroxylase?
Which cofactor is essential for the enzyme tyrosine hydroxylase?
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How are biogenic amines primarily synthesized?
How are biogenic amines primarily synthesized?
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Which of the following functions is NOT associated with biogenic amines?
Which of the following functions is NOT associated with biogenic amines?
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What role do monoamine oxidases (MAO) play in the body?
What role do monoamine oxidases (MAO) play in the body?
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Which statement about biogenic amines degradation is true?
Which statement about biogenic amines degradation is true?
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Which co-substrate is required for the degradation of biogenic amines by monoamine oxidases?
Which co-substrate is required for the degradation of biogenic amines by monoamine oxidases?
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What is a common consequence of monoamine oxidase A deficiency?
What is a common consequence of monoamine oxidase A deficiency?
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Which substance can potentially build up due to vitamin B12 deficiency?
Which substance can potentially build up due to vitamin B12 deficiency?
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What type of biogenic amine is cadaverine classified as?
What type of biogenic amine is cadaverine classified as?
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Which biogenic amine is synthesized from tryptophan?
Which biogenic amine is synthesized from tryptophan?
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What is the primary role of agmatine as a biogenic amine?
What is the primary role of agmatine as a biogenic amine?
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Which of the following biogenic amines plays a significant role in the fight or flight response?
Which of the following biogenic amines plays a significant role in the fight or flight response?
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Study Notes
Glycoproteins
- Proteins covalently linked to oligosaccharides or polysaccharides
- 10-15% oligosaccharide in weight by mass
Amino Sugars
- Sugar molecules with amino and acetate groups
- Example: N-acetylglucosamine (GlcNAc)
N-Linked Glycosylation
- GlcNAc is added to the amide nitrogen of an asparagine (Asn) residue
- Asn-X-Ser/Thr consensus sequence required where X is any amino acid except proline
- Glycosylation occurs within the ER lumen
O-Linked Glycosylation
- N-acetylgalactosamine (GalNAc) and other saccharides are addedto the hydroxyl group of serine (Ser) or threonine (Thr) residues
- Glycosylation occurs within the Golgi lumen
N-Linked Glycosylation Assembly and Modification
- Dolichol phosphate is a lipid carrier that spans the ER membrane
- Dolichol phosphate binds to activated sugars
- Dolichol phosphate facilitates the "flipping" of sugars across the ER membrane
- Oligosaccharyltransferase is a glycosyltransferase that adds sugars to proteins within the ER lumen
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Description
Explore the fascinating world of glycoproteins and their glycosylation processes in this quiz. Test your understanding of N-linked and O-linked glycosylation, including the roles of amino sugars and the cellular mechanisms involved. Ideal for students studying biochemistry and molecular biology.
