ENdo Pancreas

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Questions and Answers

Which hormone inhibits insulin secretion?

  • Gastrin
  • Somatostatin (correct)
  • Glucagon-like peptide1(GLP-1)
  • Gastric inhibitory peptide (GIP)

Insulin secretion is greater in response to which type of glucose intake?

  • Oral glucose intake (correct)
  • Intravenously administered glucose
  • Both oral and intravenous glucose intake
  • None of the above

Which hormone stimulates secretion of both insulin and glucagon?

  • Gastrin
  • Gastric inhibitory peptide (GIP) (correct)
  • Glucagon-like peptide1(GLP-1)
  • Cholecystokinin (CCK)

What is the normal fasting plasma glucose concentration?

<p>70-99 mg/dL (C)</p> Signup and view all the answers

Which two major hormones are secreted from the endocrine pancreas?

<p>Insulin and glucagon (A)</p> Signup and view all the answers

What are the major target organs for insulin and glucagon?

<p>Liver and muscles (A)</p> Signup and view all the answers

What is the role of the insulin/glucagon (I/G) ratio in the regulation of body metabolism?

<p>It determines the rate of glucose uptake by cells (D)</p> Signup and view all the answers

Which disease state is caused by under-secretion of insulin?

<p>Type 1 diabetes (A)</p> Signup and view all the answers

What are the complications of hyperglycemia?

<p>Kidney failure and nerve damage (D)</p> Signup and view all the answers

Which of the following transporters is responsible for insulin-stimulated glucose uptake in skeletal, adipose tissue, and cardiac muscle?

<p>GLUT-4 (A)</p> Signup and view all the answers

Which glucose transporter is primarily expressed in the brain, placenta, and testes?

<p>GLUT-3 (C)</p> Signup and view all the answers

Which glucose transporter is responsible for glucose sensing in pancreatic beta cells?

<p>GLUT-2 (A)</p> Signup and view all the answers

Which glucose transporter is responsible for transporting glucose, galactose, and fructose in the liver, pancreatic beta cells, small intestine, and kidney?

<p>GLUT-2 (C)</p> Signup and view all the answers

Which glucose transporter is primarily expressed in the skeletal muscle, adipocytes, and cardiac muscle?

<p>GLUT-4 (B)</p> Signup and view all the answers

Which cells in the pancreas secrete insulin and amylin?

<p>B cells (B)</p> Signup and view all the answers

What is the function of glucagon?

<p>To mobilize nutrient reserves (A)</p> Signup and view all the answers

Which hormone inhibits the secretion of pancreatic hormones?

<p>Somatostatin (C)</p> Signup and view all the answers

What is the half-life of insulin?

<p>3-5 minutes (D)</p> Signup and view all the answers

What is the stimulus for insulin secretion?

<p>Glucose (C)</p> Signup and view all the answers

Which of the following plasma values would best explain the homeostatic regulation of plasma glucose levels?

<p>Insulin/glucagon ratio (E)</p> Signup and view all the answers

What is the mechanism of hyperglycemia in patients with low insulin effect (diabetes)?

<p>Low glucose uptake by skeletal muscle and fat cells and high hepatic glucose output (B)</p> Signup and view all the answers

Which hormone stimulates insulin release by exocytosis from pancreatic beta cells?

<p>Glucagon (B)</p> Signup and view all the answers

Which hormone inhibits insulin secretion?

<p>Somatostatin (A)</p> Signup and view all the answers

Which glucose transporter is primarily expressed in the brain, placenta, and testes?

<p>GLUT3 (A)</p> Signup and view all the answers

Which hormone is linked to osteoporosis and bone fragility?

<p>Insulin (A)</p> Signup and view all the answers

Which of the following is a metabolic consequence of diabetes mellitus?

<p>Skeletal muscle wasting (D)</p> Signup and view all the answers

Which of the following is a complication of hyperglycemia in diabetes?

<p>Neuropathy (A)</p> Signup and view all the answers

Which glucose transporter is primarily expressed in the liver, pancreatic beta cells, small intestine, and kidney?

<p>GLUT-2 (D)</p> Signup and view all the answers

Which plasma glucose level is considered normal after a meal?

<blockquote> <p>200 mg/dL (B)</p> </blockquote> Signup and view all the answers

What is the major reason for complications of diabetes mellitus?

<p>Hyperglycemia (A)</p> Signup and view all the answers

Which glucose transporter is responsible for glucose sensing in pancreatic beta cells?

<p>GLUT-2 (A)</p> Signup and view all the answers

Which hormone stimulates glycogenolysis and gluconeogenesis in response to hypoglycemia?

<p>Glucagon (A)</p> Signup and view all the answers

Which glucose transporter is primarily expressed in the skeletal muscle, adipocytes, and cardiac muscle?

<p>GLUT-4 (D)</p> Signup and view all the answers

Which glucose transporter is primarily expressed in the brain, placenta, and testes?

<p>GLUT-3 (D)</p> Signup and view all the answers

Which of the following is NOT a hormonal response to low blood glucose levels?

<p>Increased cortisol secretion (E)</p> Signup and view all the answers

Which hormone is responsible for stimulating glycogenolysis in the liver and in the muscle?

<p>Epinephrine (C)</p> Signup and view all the answers

What is the primary mechanism of hyperglycemia in patients with low insulin effect (diabetes)?

<p>Low glucose uptake by skeletal muscle and fat cells (C)</p> Signup and view all the answers

True or False: Insulin receptors exist only in the skeletal and cardiac muscle and fat cells.

<p>False (A)</p> Signup and view all the answers

Which cells in the pancreas secrete insulin and amylin?

<p>Beta cells (D)</p> Signup and view all the answers

What is the role of insulin/glucagon (I/G) ratio in the regulation of body metabolism?

<p>The I/G ratio affects the balance between anabolic and catabolic processes in the body (C)</p> Signup and view all the answers

What are the major target organs for insulin and glucagon?

<p>Insulin: liver, muscle, and adipose tissue; Glucagon: liver (C)</p> Signup and view all the answers

What is the function of glucagon?

<p>Glucagon stimulates glycogen breakdown and gluconeogenesis in the liver (C)</p> Signup and view all the answers

Which hormone is responsible for mobilizing glycogen, fat, and protein to serve as energy sources during periods of food deprivation?

<p>Glucagon (C)</p> Signup and view all the answers

What is the primary function of C-peptide?

<p>Protects functional β-cells from oxidative stress (A)</p> Signup and view all the answers

What are the steps of insulin secretion in response to increased plasma glucose concentration?

<p>Glucose enters the β cells via GLUT2 transporter, glucose → glucose-P → → ↑ATP production, ATP binds to the ATP-sensitive K+ channels (KATP) → ↓K+ efflux → β cell depolarization (C)</p> Signup and view all the answers

What is the primary function of insulin?

<p>Mobilizes glycogen, fat, and protein to serve as energy sources (C)</p> Signup and view all the answers

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