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Questions and Answers
Which of the following compounds can serve as a precursor for gluconeogenesis?
Which of the following compounds can serve as a precursor for gluconeogenesis?
- Nucleotides
- Lactate (correct)
- Cholesterol
- Triglycerides
In which cellular compartment does most gluconeogenesis primarily occur?
In which cellular compartment does most gluconeogenesis primarily occur?
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- Cytosol (correct)
Which organ plays the most significant role in gluconeogenesis?
Which organ plays the most significant role in gluconeogenesis?
- Heart
- Pancreas
- Kidneys
- Liver (correct)
Which of these tissues rely exclusively on glucose for energy supply?
Which of these tissues rely exclusively on glucose for energy supply?
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Which of the following is NOT a major precursor for gluconeogenesis?
Which of the following is NOT a major precursor for gluconeogenesis?
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Study Notes
What is Gluconeogenesis?
- Gluconeogenesis is the process of creating glucose from non-carbohydrate sources.
- This process is crucial for maintaining blood glucose levels when carbohydrate intake is low.
- Key precursors for gluconeogenesis are lactate, pyruvate, glucogenic amino acids, propionate, and glycerol.
Where Does Gluconeogenesis Take Place?
- The process mostly occurs in the cytosol of liver cells.
- Some precursors are produced in mitochondria.
- The kidneys also contribute to gluconeogenesis to a lesser extent.
Importance of Gluconeogenesis
- Several vital organs rely solely on glucose for energy, including the brain, central nervous system, erythrocytes, testes, and kidney medulla.
- Glucose is the only source of energy for skeletal muscles and red blood cells under anaerobic conditions.
- This emphasizes the importance of gluconeogenesis in maintaining energy supply, even in times of limited carbohydrate availability.
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