Glycolysis and Gluconeogenesis slides quiz
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Questions and Answers

Which phase of glycolysis is responsible for generating ATP?

  • Both phases generate ATP
  • Phase II: ATP-generating phase (correct)
  • Neither phase generates ATP
  • Phase I: Preparative Phase
  • Which enzyme is responsible for the first reaction of glycolysis?

  • Triose Phosphate Isomerase
  • Hexokinase (correct)
  • Aldolase
  • Enolase
  • Which step(s) of glycolysis are irreversible?

  • Reaction 3
  • Reaction 1
  • Reaction 2
  • Both Reaction 1 and Reaction 2 (correct)
  • What is the role of Mg2+ cofactor in glycolysis?

    <p>To catalyze Reaction 1</p> Signup and view all the answers

    Which step of glycolysis requires an input of energy?

    <p>Reaction 1</p> Signup and view all the answers

    Which step of glycolysis produces energy directly?

    <p>Reaction 3</p> Signup and view all the answers

    What is the net energy yield from a cycle of glycolysis?

    <p>2 ATP</p> Signup and view all the answers

    Which of the following reactions is the rate-limiting and committing step of glycolysis?

    <p>Reaction 3</p> Signup and view all the answers

    What is the standard Gibbs free energy change ($\Delta G^0$) for Reaction 4 in glycolysis?

    <p>+23.9 kJ/mol</p> Signup and view all the answers

    Which enzyme catalyzes Reaction 9 in glycolysis?

    <p>Enolase</p> Signup and view all the answers

    How many ATP molecules are required during the preparatory phase of glycolysis?

    <p>2 ATP</p> Signup and view all the answers

    What is the net ATP production per glucose molecule in glycolysis through substrate-level phosphorylation?

    <p>2 ATP</p> Signup and view all the answers

    What happens to pyruvate under aerobic conditions?

    <p>It enters the citric acid cycle</p> Signup and view all the answers

    Which of the following reactions is NOT one of the three irreversible reactions in glycolysis?

    <p>Reaction 5: Triose phosphate isomerase</p> Signup and view all the answers

    Which enzyme is responsible for the carboxylation of pyruvate in the gluconeogenesis pathway?

    <p>Pyruvate carboxylase</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of fructose 1,6-bisphosphate to fructose 6-phosphate in the gluconeogenesis pathway?

    <p>Fructose 1,6-bisphosphatase</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of glucose 6-phosphate to glucose in the gluconeogenesis pathway?

    <p>Glucose-6 Phosphatase</p> Signup and view all the answers

    Which of the following is NOT a precursor for gluconeogenesis?

    <p>Pyruvate</p> Signup and view all the answers

    Which of the following is a glucogenic amino acid?

    <p>Alanine</p> Signup and view all the answers

    What is the cellular location of pyruvate carboxylase?

    <p>Mitochondria</p> Signup and view all the answers

    What is the main symptom of inherited disorders of gluconeogenesis?

    <p>Poor growth and development</p> Signup and view all the answers

    Which shuttle system is used when the starting substrate is alanine?

    <p>Malate shuttle</p> Signup and view all the answers

    What is the product of the malate shuttle once it crosses the inner mitochondrial membrane?

    <p>Malate</p> Signup and view all the answers

    What is malate converted back to in the cytosol?

    <p>Oxaloacetate</p> Signup and view all the answers

    What is the starting substrate for the shuttle for lactate?

    <p>Lactate</p> Signup and view all the answers

    What is pyruvate converted to in the mitochondria during the shuttle for lactate?

    <p>Oxaloacetate</p> Signup and view all the answers

    What is phosphoenolpyruvate (PEP) shuttled out of the mitochondria to continue with gluconeogenesis?

    <p>Phosphoenolpyruvate</p> Signup and view all the answers

    What can glycerol be converted to in gluconeogenesis?

    <p>Dihydroxyacetone phosphate</p> Signup and view all the answers

    Which process is shown in the image labeled 'Glycolysis & Gluconeogenesis'?

    <p>Gluconeogenesis</p> Signup and view all the answers

    Which shuttle system is used when the starting substrate is glucose?

    <p>Oxaloacetate shuttle</p> Signup and view all the answers

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