Globular Proteins
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Globular Proteins

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Questions and Answers

What is an important feature of globular proteins?

  • Compact shape with rounded structure (correct)
  • Exclusively enzymatic function
  • Insolubility in water
  • Limited biological functions
  • What gives the name 'heme proteins' to Myoglobin and Hemoglobin?

  • Prosthetic group
  • Heme group (correct)
  • Apoprotein part
  • Unique subunit
  • Where is Myoglobin found and what is its function?

  • In muscle; oxygen storage (correct)
  • In erythrocytes; oxygen transport
  • In blood plasma; immune function
  • In liver; enzymatic function
  • What is the role of Hemoglobin in the body?

    <p>Carrier of oxygen through bloodstream</p> Signup and view all the answers

    What is the prosthetic group present in both myoglobin and hemoglobin?

    <p>Heme group</p> Signup and view all the answers

    What type of structure does hemoglobin have?

    <p>Quaternary structure</p> Signup and view all the answers

    What is the role of distal histidine in myoglobin and hemoglobin?

    <p>Entry of oxygen instead of CO</p> Signup and view all the answers

    What is the state of the iron atom in the heme group?

    <p>Ferrous (Fe2+)</p> Signup and view all the answers

    What does myoglobin's hydrophobic pocket do?

    <p>Protects the heme group from oxidation</p> Signup and view all the answers

    What is the name of the complex organic ring structure in the heme group?

    <p>Protoporphyrin</p> Signup and view all the answers

    What is the role of proximal histidine in myoglobin and hemoglobin?

    <p>Coordinated (bound) with iron perpendicularly</p> Signup and view all the answers

    What does the heme group allow myoglobin and hemoglobin to do?

    <p>Store and carry oxygen</p> Signup and view all the answers

    Study Notes

    Globular Proteins

    • Globular proteins are characterized by their compact, spherical shape, allowing them to be soluble in water.

    Heme Proteins

    • Myoglobin and Hemoglobin are classified as "heme proteins" due to the presence of heme, an iron-containing prosthetic group that facilitates oxygen binding.

    Myoglobin

    • Myoglobin is primarily located in muscle tissue, where it serves to store and transport oxygen to muscle cells.

    Hemoglobin

    • Hemoglobin plays a crucial role in transporting oxygen from the lungs to tissues and returns carbon dioxide from tissues back to the lungs.

    Prosthetic Group

    • Both Myoglobin and Hemoglobin contain the heme group as their prosthetic group, enabling oxygen binding.

    Hemoglobin Structure

    • Hemoglobin has a quaternary structure, composed of four peptide chains (two alpha and two beta chains), forming a tetramer.

    Distal Histidine

    • The distal histidine plays a significant role in stabilizing the bound oxygen molecule in both Myoglobin and Hemoglobin by facilitating the proper orientation of oxygen.

    Iron State

    • In the heme group, the iron atom is in the ferrous state (Fe²⁺) when it binds oxygen, allowing for reversible binding.

    Hydrophobic Pocket

    • Myoglobin's hydrophobic pocket is crucial for protecting the heme group from solvent interactions, ensuring stable binding and release of oxygen.

    Heme Group Structure

    • The heme group consists of a complex organic ring structure known as porphyrin, which houses the iron atom at its center.

    Proximal Histidine

    • The proximal histidine coordinates directly with the iron atom in the heme group, facilitating the binding of oxygen molecules.

    Function of Heme Group

    • The heme group enables both Myoglobin and Hemoglobin to bind to oxygen, critically supporting aerobic respiration in living organisms.

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    Description

    Test your knowledge of globular proteins and their structure-function relationship in this biochemistry quiz. Explore the characteristics and biological functions of these compact, water-soluble proteins found in cells and blood.

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