Glial Cells in the Nervous System
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Questions and Answers

What is the name of the cells that create myelin sheaths around nerves in the peripheral nervous system?

Schwann cells

What type of cells are responsible for myelinating nerve fibers in the central nervous system?

Oligodendrocytes

What is the function of microglia cells?

Microglia help protect nerve cells by removing harmful substances.

Which of the following are functions of astrocytes? (Select all that apply)

<p>Connect to blood vessels and help form the blood-brain barrier (A), Surround and support nerve cell connections (synapses) and nerve cell surfaces (B), Have receptors that respond to various neurotransmitters (C), Produce substances that nourish nerve cells and help control the levels of ions and neurotransmitters (D)</p> Signup and view all the answers

Neurotransmitters are substances that are released by neurons to communicate with other cells. Which of the following is NOT a function of neuroglia cells?

<p>Producing neurotransmitters (D)</p> Signup and view all the answers

The human nervous system is comprised of neurons and neuroglia cells.

<p>True (A)</p> Signup and view all the answers

Neuroglia cells help in the electrical signal transmission in the nervous system.

<p>False (B)</p> Signup and view all the answers

Schwann cells are found in the Central Nervous System.

<p>False (B)</p> Signup and view all the answers

Oligodendrocytes are responsible for creating the myelin sheath in the peripheral nervous system.

<p>False (B)</p> Signup and view all the answers

A stimulus can be a mechanical signal, like hitting your knee with a mallet.

<p>True (A)</p> Signup and view all the answers

What is the name of the long, slender projection of a neuron that transmits nerve impulses?

<p>Axon</p> Signup and view all the answers

What is the name of the junction between two neurons where a signal is transmitted?

<p>Synapse</p> Signup and view all the answers

Nervous impulses are commonly transmitted through the neuron electrically using ion transport.

<p>True (A)</p> Signup and view all the answers

What are the two main ions responsible for the propagation of nerve impulses?

<p>Sodium (Na+) and Potassium (K+) (D)</p> Signup and view all the answers

Electrical events in neurons are measured in milliseconds, and the potential changes are measured in microvolts.

<p>False (B)</p> Signup and view all the answers

What is the name of the pump that actively transports sodium and potassium ions across the neuronal membrane?

<p>Na+/K+ ATPase</p> Signup and view all the answers

What does ATP stand for?

<p>Adenosine triphosphate</p> Signup and view all the answers

What is the resting membrane potential of a neuron?

<p>-70 mV (A)</p> Signup and view all the answers

The resting membrane potential is maintained because of the unequal distribution of ions across the neuronal membrane.

<p>True (A)</p> Signup and view all the answers

The concentration of sodium ions is greater inside the cell than outside the cell during resting state.

<p>False (B)</p> Signup and view all the answers

The concentration of potassium ions is greater outside the cell than inside the cell during resting state.

<p>False (B)</p> Signup and view all the answers

The resting membrane potential is important for the initiation of action potentials because it provides a baseline for the membrane to be depolarized.

<p>True (A)</p> Signup and view all the answers

The membrane becomes hyperpolarized after the action potential.

<p>True (A)</p> Signup and view all the answers

What is the name of the process that occurs when the membrane potential of a neuron becomes more positive?

<p>Depolarization (D)</p> Signup and view all the answers

What is the name of the process that occurs when the membrane potential of a neuron returns to its resting potential?

<p>Repolarization (B)</p> Signup and view all the answers

What is the name of the process that occurs when the membrane potential of a neuron becomes more negative than its resting potential?

<p>Hyperpolarization (B)</p> Signup and view all the answers

An action potential is an all-or-none event, meaning that it either occurs fully or not at all.

<p>True (A)</p> Signup and view all the answers

If the stimulus is too low, there is no action potential.

<p>True (A)</p> Signup and view all the answers

The amplitude of the action potential can vary according to the strength of the stimulus.

<p>False (B)</p> Signup and view all the answers

The refractory period is a time when the neuron is unable to fire another action potential.

<p>True (A)</p> Signup and view all the answers

What is the name of the gap between the myelin sheath where the action potential can jump?

<p>Nodes of Ranvier</p> Signup and view all the answers

Myelinated neurons transmit signals faster than unmyelinated neurons.

<p>True (A)</p> Signup and view all the answers

What is the role of myelin?

<p>Insulate the neuron and increase the speed of signal conduction (B)</p> Signup and view all the answers

The speed of nerve conduction is influenced by the diameter of the nerve. Thicker nerve fibers (axons) transmit impulses faster.

<p>True (A)</p> Signup and view all the answers

The speed of nerve conduction is influenced by temperature. Nerve conductions travel faster in warmer temperatures.

<p>True (A)</p> Signup and view all the answers

Flashcards

Schwann Cells

Specialized cells that support and protect neurons in the peripheral nervous system (PNS). They wrap around axons to form myelin sheaths, which insulate and speed up nerve impulse conduction.

Oligodendrocytes

Specialized cells that support and protect neurons in the central nervous system (CNS). Similar to Schwann cells, they create myelin sheaths around axons, enhancing nerve impulse conduction.

Microglia

Immune cells of the CNS that protect neurons by removing debris, pathogens, and other harmful substances.

Astrocytes

Star-shaped glial cells that perform various crucial functions in the CNS, including:

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Blood-Brain Barrier

A protective barrier that restricts the passage of certain substances from the bloodstream into the brain. It is formed by astrocytes and capillaries.

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Synapses

The junction between two neurons where communication occurs. Astrocytes surround and support these connections.

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Astrocytic Nourishment & Regulation

Astrocytes produce substances that nourish neurons and help regulate the levels of ions and neurotransmitters.

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Astrocytic Neurotransmitter Receptors

Astrocytes have receptors that respond to various neurotransmitters, allowing them to sense and influence neuronal activity.

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Neural Excitation & Conduction

The process by which a neuron generates and transmits an electrical signal.

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Ion Transport

The movement of ions across the cell membrane, which is the basis of electrical signaling in neurons.

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Speed of Neural Impulses

The electrical activity in neurons is very fast, measured in milliseconds (ms).

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Potential Changes

The change in voltage across the neuron's membrane during an electrical impulse.

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Conduction Velocity

Even though conduction of nerve impulses is rapid, it is much slower than the flow of electricity through a wire.

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Key Ions in Action Potentials

Sodium (Na+) and potassium (K+) are the main ions involved in the propagation of nerve impulses (action potentials).

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Resting Membrane Potential

The difference in electrical charge between the inside and outside of a neuron's membrane when it's not transmitting a signal.

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Na+/K+ ATPase

The sodium-potassium pump (Na+/K+ ATPase) actively transports ions across the membrane, maintaining the resting membrane potential.

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Na+/K+ ATPase Ion Exchange

The Na+/K+ ATPase pumps 3 Na+ ions out of the cell and 2 K+ ions into the cell for every cycle, contributing to the negative charge inside the neuron.

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Potassium Ion Concentration

The concentration of K+ ions is higher inside the neuron compared to outside, contributing to the resting membrane potential.

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Sodium Ion Concentration

The concentration of Na+ ions is much higher outside the neuron compared to inside, contributing to the resting membrane potential.

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Membrane Action Potential

The process by which a neuron generates an electrical signal (action potential) in response to a stimulus.

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Na+ Channel Opening

The opening of Na+ channels allows Na+ ions to rush into the neuron, causing depolarization.

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Depolarization

The influx of positive charges (Na+) makes the inside of the neuron more positive, reversing the membrane potential towards zero.

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Peak Depolarization

The membrane potential becomes positive (around +30 mV) as Na+ accumulates inside the neuron.

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K+ Channel Opening

The opening of K+ channels allows K+ ions to rush out of the neuron, causing repolarization.

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Repolarization

The membrane potential becomes negative again as K+ ions leave the neuron.

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Hyperpolarization

The membrane potential temporarily becomes even more negative than the resting potential (about -100 mV) as K+ ions continue to leave.

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Resting Potential Restoration

The Na+/K+ ATPase pumps Na+ ions out and K+ ions in, restoring the resting membrane potential.

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Refractory Period

A short period following an action potential when the neuron is less sensitive to stimulation.

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Absolute Refractory Period

A period during which the neuron cannot generate another action potential, no matter how strong the stimulus.

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Relative Refractory Period

A period during which the neuron can generate another action potential but only with a stronger than usual stimulus.

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Impulse Conduction

The process by which an action potential travels along the neuron's axon.

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Factors Affecting Conduction Speed

The speed of impulse conduction can be influenced by the size of the neuron, temperature, and the presence of myelin.

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Influence of Myelin

Myelinated axons conduct impulses much faster than non-myelinated axons.

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All-or-None Law

A neuron will fire a maximal action potential if the stimulus reaches a certain threshold, or it will not fire at all if the stimulus is below that threshold.

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Study Notes

Glial Cells

  • Glial cells, also known as neuroglia cells, are supporting cells in the nervous system.
  • They do not participate in neural transmission; their only role is to support neurons.
  • Different types of glial cells include Schwann cells, oligodendrocytes, microglia, and astrocytes.

Types of Glial Cells

  • Schwann cells: Create myelin sheaths around nerves in the peripheral nervous system (PNS).
  • Oligodendrocytes: Create myelin sheaths around nerves in the central nervous system (CNS).
  • Microglia: Help protect nerve cells by removing harmful substances.
  • Astrocytes: Found throughout the brain, these cells have multiple functions:
    • Connecting to blood vessels and aiding in the formation of the blood-brain barrier to protect the brain.
    • Supporting nerve cell connections (synapses) and nerve cell surfaces.
    • Producing substances that nourish nerve cells and regulate ion and neurotransmitter levels.
    • Possessing receptors that respond to various neurotransmitters.

Neural Excitation and Conduction

  • Neural stimulation can be electrical, chemical, or mechanical.
  • Neural impulses are transmitted electrically via ion transport across the cell membrane, primarily involving sodium (Na+) and potassium (K+).
  • Electrical events in neurons occur rapidly, measured in milliseconds (ms), with potential changes measured in millivolts (mV).
  • Neural impulse conduction is slower than the speed of electricity.

Resting Membrane Potential

  • The nerve cell membrane is polarized in its resting state due to active ion transport by the Na+/K+ ATPase pump.
  • This pump actively transports 3 sodium ions (Na+) out of the cell and 2 potassium ions (K+) into the cell, resulting in a net positive charge outside the cell and a negative charge inside.
  • The separation of charges creates the resting membrane potential, typically measured at -70mV.
  • The concentrations of ions (K+, Na+, Cl-, Ca2+) on either side of the axon membrane are different.

Mechanism of Membrane Action Potential

  • Action potential initiation typically begins with a stimulus causing the opening of Na+ channels inside the nerve cell
  • The rapid influx of positive charge (Na+) causes Depolarization.
  • Following depolarization, there's a rapid efflux of K+ out of the cell, leading to repolarization.
  • The membrane potential briefly hyperpolarizes before returning to its resting state via the Na+/K+ ATPase pump.

Refractory Period

  • Once an action potential begins, a brief refractory period occurs where the membrane is insensitive to further stimulation.
  • There are two types: absolute and relative refractory periods.
    • During the absolute refractory period, no stimulus, no matter how large, can trigger another action potential.
    • During the relative refractory period, a stronger-than-usual stimulus is required to initiate another action potential.

Impulse Conduction

  • Electrical impulses travel along neurons at variable speeds (1-120 m/s) influenced by factors such as nerve diameter, temperature, and the presence/absence of myelin.
  • Myelinated neurons conduct impulses faster than unmyelinated neurons.
  • Myelin sheath in myelinated neurons increases the speed of impulse conduction by insulating the axon and allowing depolarization only at the nodes of Ranvier. This results in "saltatory conduction".

All-or-None Law

  • Action potentials either occur fully or not at all.
  • The size of an action potential is independent of stimulus strength; only the frequency of action potentials can vary with stimulus strength.

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Explore the fascinating world of glial cells, the unsung heroes of the nervous system. This quiz dives into the various types of glial cells, including Schwann cells, oligodendrocytes, microglia, and astrocytes, detailing their vital supportive roles and functions. Test your knowledge on how these cells contribute to the overall health and functioning of the nervous system.

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