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Questions and Answers
What is the spectrum of disorder resulting from an abnormal placental growth and invasion?
Which disease retains certain characteristics of the normal placenta such as invasive tendencies and the ability to make hCG hormone?
What is considered the regimen of choice in most high-risk patients with gestational trophoblastic neoplasia (GTN)?
What is the overall survival rate for patients with cerebral or hepatic metastases in gestational trophoblastic neoplasia (GTN)?
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When is total abdominal hysterectomy performed in patients with gestational trophoblastic neoplasia (GTN)?
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What is the main characteristic of psoriasis?
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What is the exact cause of psoriasis?
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What is the inheritance mode in psoriasis characterized by early onset with positive family history?
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What is the risk of a child being affected by psoriasis if both parents have the condition?
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What genotype increases the risk of developing psoriasis by 20 times?
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Study Notes
Gestational Trophoblastic Neoplasia (GTN)
- Spectrum of disorder resulting from abnormal placental growth and invasion includes hydatidiform moles, invasive moles, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor.
- Choriocarcinoma retains characteristics of normal placenta, including invasive tendencies and ability to produce hCG hormone.
Treatment of GTN
- Multi-agent chemotherapy is the regimen of choice for most high-risk patients with GTN.
- Overall survival rate for patients with cerebral or hepatic metastases is approximately 50-60%.
Surgery in GTN
- Total abdominal hysterectomy is performed in patients with GTN who have completed childbearing or in cases where chemotherapy is ineffective.
Psoriasis
Characteristics and Causes
- Main characteristic of psoriasis is chronic inflammation leading to skin lesions with thick, scaly, red, and sometimes painful patches.
- Exact cause of psoriasis is unknown, but involves immune system, genetics, and environmental factors.
Inheritance and Risk
- Inheritance mode in psoriasis characterized by early onset with positive family history is autosomal dominant.
- If both parents have psoriasis, the risk of a child being affected is 50%.
- Genotype HLA-Cw6 increases the risk of developing psoriasis by 20 times.
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Description
Test your knowledge about gestational trophoblastic disease, from its definition and characteristics to macroscopic features of molar pregnancy. Learn about the spectrum of disorders resulting from abnormal placental growth and invasion.
